Species: Homo sapiens

Position: chr15: 41282696-41313338

Known as: OIP5-AS1 , ENSG00000247556

Transcript: NR_152821 , NR_152820 , NR_152822 , NR_026757 , ENST00000500949

Sequence: Display Download

Description:

The long ncRNA Cyrano uses an extensively paired site to miR-7 to trigger destruction of this microRNA. Cyrano-directed miR-7 degradation is much more effective than previously described examples of target-directed microRNA degradation, which come primarily from studies of artificial and viral RNAs. By reducing miR-7 levels, Cyrano prevents repression of miR-7 targeted mRNAs and enables accumulation of Cdr1as, a circular RNA known to regulate neuronal activity. Without Cyrano, excess miR-7 causes cytoplasmic destruction of Cdr1as in neurons, in part through enhanced slicing of Cdr1as by a second miRNA, miR-671. Thus, several types of ncRNAs can collaborate to establish a sophisticated regulatory network. In zebrafish, Cyrano is expressed throughout the developing nervous system. In the mouse embryo, Cyrano was also enriched in the early central and peripheral nervous systems. In adult mice, Cyrano was broadly expressed with 5-10-fold higher expression in brain regions and muscle, a pattern largely conserved in human. Within brain, Cyrano appeared more highly expressed in neurons than glia, and within cells, Cyrano was mostly in cytoplasm.

1. Kleaveland B, Shi CY, Stefano J, Bartel DP (2018). A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain. Cell 174(2): 350-362.e17.