LncAsIR
Species: Mus musculus
Position: chr9: 102739647-102756685
Known as: Gm5627 , ENSMUSG00000093812
Transcript: NR_033301 , ENSMUST00000178539
Sequence: Download
Description:
LncAsIR is transcribed from a super enhancer region and responds robustly to insulin treatment. silencing LncAsIR resulted in an impaired global insulin-responsive gene program. LncAsIR is a novel and integral component in the insulin signalling pathway in adipocytes.
sgRNAs
| sgRNA_ID | Sequence | Position (Chr) | Position (Lnc) | Length | PAM | Type | Validity | Cell line | Note | Ref. |
|---|---|---|---|---|---|---|---|---|---|---|
| sgRNA1 | ACTCTGACAACAGATTAACG | 102756380-102756399(-) | gene body (near 3') | 20 | AGG | CRISPRi | Experimental validated | preadipocytes | NA | [1] |
| sgRNA2 | GTCACGTATTCAGCCAATGG | 102756477-102756496(-) | gene body (near 3') | 20 | CGG | CRISPRi | Experimental validated | preadipocytes | NA | [1] |
GBrowser
Links
Reference
1. Degirmenci U, Li J, Lim YC, Siang DTC, Lin S, et al. (2019). Silencing an insulin-induced lncRNA, LncASIR, impairs the transcriptional response to insulin signalling in adipocytes. Sci Rep 9(1): 5608.
