Conserved lncRNA

We used three methods (that are direct BLASTN, collinearity with conserved coding gene, and overlap with multi-species ultra-conserved non-coding elements (UCNE)) to find the counterparts of zebrafish lncRNAs in human or mouse. In direct comparison of zebrafish lncRNA and human/mouse lncRNA with BLASTN, bidirectional best hits using a relatively non-stringent threshold (E-value<=10-5) were considered as orthologs. In collinearity method, we compared the coding genes of zebrafish with those of human or mouse using BLASTP as anchor points. We assumed that those lncRNAs with more than 5 anchor points in the 20k upstream/downstream region are orthologs. In UCNE method, if two lncRNAs from different species overlap with at least one UCNE, as another anchor point, they were considered as orthologs. Finally, we obtained 2,156 zebrafish lncRNA genes that have the counterpart in human or mouse.


Zebrafish lncRNA Transcript Zebrafish lncRNA Gene Human lncRNA Transcript Mouse lncRNA Transcript
ZFLNCT19136 ZFLNCG12359 NONMMUT052100;
ZFLNCT19137 ZFLNCG12359 NONMMUT052100;
ZFLNCT20199 ZFLNCG13029 NONMMUT041995;
ZFLNCT20200 ZFLNCG13029 NONMMUT041995;
ZFLNCT20201 ZFLNCG13029 NONMMUT041995;
ZFLNCT20341 ZFLNCG13104 NONHSAT149428;
ZFLNCT20411 ZFLNCG13147 ENST00000426194; rna114383; ENSMUST00000139804; ENSMUST00000144487; ENSMUST00000143378; ENSMUST00000132729; NONMMUT031657; NONMMUT031656; NONMMUT031654;
ZFLNCT20412 ZFLNCG13147 ENST00000426194; rna114383; ENSMUST00000139804; ENSMUST00000144487; ENSMUST00000143378; ENSMUST00000132729; NONMMUT031657; NONMMUT031656; NONMMUT031654;
ZFLNCT21041 ZFLNCG13543 NONHSAT044219;