ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 39/356 191/7206 1.17172523781e-14 ko04621 NOD-like receptor signaling pathway 35/356 157/7206 1.80168763573e-14 ko05164 Influenza A 35/356 167/7206 1.29995945801e-13 ko04380 Osteoclast differentiation 30/356 134/7206 1.30792765549e-12 ko05340 Primary immunodeficiency 15/356 30/7206 1.50430949705e-12 ko04064 NF-kappa B signaling pathway 24/356 96/7206 2.07498355898e-11 ko05168 Herpes simplex infection 32/356 182/7206 2.05790358977e-10 ko04217 Necroptosis 31/356 178/7206 5.13158052969e-10 ko05162 Measles 25/356 120/7206 5.4014070867e-10 ko05140 Leishmaniasis 19/356 75/7206 2.13108559939e-09 ko04630 Jak-STAT signaling pathway 25/356 132/7206 4.40135076615e-09 ko04659 Th17 cell differentiation 22/356 106/7206 6.53321846273e-09 ko05145 Toxoplasmosis 24/356 126/7206 8.05509830873e-09 ko05321 Inflammatory bowel disease (IBD) 15/356 56/7206 4.84278304557e-08 ko04620 Toll-like receptor signaling pathway 20/356 100/7206 6.25271573032e-08 ko05152 Tuberculosis 28/356 187/7206 1.10766892105e-07 ko04658 Th1 and Th2 cell differentiation 19/356 96/7206 1.60267470156e-07 ko04660 T cell receptor signaling pathway 21/356 124/7206 5.69298116673e-07 ko04612 Antigen processing and presentation 16/356 77/7206 7.76718998456e-07 ko05133 Pertussis 17/356 87/7206 8.79805907637e-07 ko04650 Natural killer cell mediated cytotoxicity 18/356 97/7206 9.32554031131e-07 ko04672 Intestinal immune network for IgA production 11/356 37/7206 9.83206784086e-07 ko04623 Cytosolic DNA-sensing pathway 11/356 41/7206 3.03880035643e-06 ko05150 Staphylococcus aureus infection 10/356 36/7206 6.12534352418e-06 ko05320 Autoimmune thyroid disease 9/356 29/7206 6.58180560362e-06 ko04622 RIG-I-like receptor signaling pathway 13/356 62/7206 7.69317376028e-06 ko05323 Rheumatoid arthritis 15/356 89/7206 2.55431052321e-05 ko05161 Hepatitis B 22/356 173/7206 3.81200601064e-05 ko04668 TNF signaling pathway 17/356 120/7206 7.56066277558e-05 ko05034 Alcoholism 1/356 238/7206 0.000105843022117 ko05330 Allograft rejection 7/356 24/7206 0.000112866750506 ko05160 Hepatitis C 19/356 153/7206 0.000176897826771 ko05142 Chagas disease (American trypanosomiasis) 17/356 130/7206 0.000206330303937 ko05167 Kaposi's sarcoma-associated herpesvirus infection 22/356 191/7206 0.0002248165437 ko05144 Malaria 9/356 45/7206 0.000288571197544 ko00120 Primary bile acid biosynthesis 6/356 20/7206 0.000299270939534 ko04062 Chemokine signaling pathway 22/356 201/7206 0.00038615477205 ko04210 Apoptosis 20/356 180/7206 0.000633874506643 ko00590 Arachidonic acid metabolism 9/356 52/7206 0.000882636141271 ko05310 Asthma 5/356 17/7206 0.00108128819759 ko04662 B cell receptor signaling pathway 12/356 88/7206 0.00120596956207 ko05332 Graft-versus-host disease 5/356 18/7206 0.00143719559399 ko04610 Complement and coagulation cascades 11/356 79/7206 0.00160940243971 ko04310 Wnt signaling pathway 1/356 181/7206 0.00244586068748 ko04145 Phagosome 17/356 162/7206 0.00281564463496 ko05134 Legionellosis 10/356 74/7206 0.00324785494919 ko03013 RNA transport 1/356 166/7206 0.00331818878056 ko04080 Neuroactive ligand-receptor interaction 9/356 423/7206 0.00362762343958 ko04640 Hematopoietic cell lineage 9/356 64/7206 0.00392352629283 ko03050 Proteasome 8/356 54/7206 0.00464792940795 ko04360 Axon guidance 3/356 233/7206 0.00504800207421 ko05131 Shigellosis 10/356 82/7206 0.00682432280163 ko05132 Salmonella infection 11/356 98/7206 0.0086633286462 ko05166 HTLV-I infection 24/356 292/7206 0.0125473905296 ko00592 alpha-Linolenic acid metabolism 4/356 19/7206 0.0125792713653 ko05020 Prion diseases 6/356 40/7206 0.0128827061939 ko04020 Calcium signaling pathway 5/356 265/7206 0.0137802085964 ko00140 Steroid hormone biosynthesis 6/356 41/7206 0.0144821493275 ko04713 Circadian entrainment 1/356 136/7206 0.0148742162679 ko04114 Oocyte meiosis 1/356 139/7206 0.0153433996302 ko04611 Platelet activation 15/356 163/7206 0.0168299592291 ko05416 Viral myocarditis 7/356 55/7206 0.0177924122406 ko04666 Fc gamma R-mediated phagocytosis 12/356 122/7206 0.0189865688707 ko04530 Tight junction 4/356 228/7206 0.019004413662 ko04940 Type I diabetes mellitus 5/356 32/7206 0.0191666376141 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/356 5/7206 0.0220361712323 ko00281 Geraniol degradation 2/356 5/7206 0.0220361712323 ko04390 Hippo signaling pathway 3/356 188/7206 0.0258586002877 ko05169 Epstein-Barr virus infection 17/356 206/7206 0.033077928187 ko04724 Glutamatergic synapse 2/356 152/7206 0.0349995738442 ko04514 Cell adhesion molecules (CAMs) 12/356 130/7206 0.0368803829084 ko04917 Prolactin signaling pathway 9/356 87/7206 0.0390506448567 ko04657 IL-17 signaling pathway 9/356 87/7206 0.0390506448567 ko04972 Pancreatic secretion 1/356 111/7206 0.0444644349561 ko00980 Metabolism of xenobiotics by cytochrome P450 5/356 40/7206 0.0455368642986 ko05224 Breast cancer 3/356 174/7206 0.0491149199909 ko00966 Glucosinolate biosynthesis 1/356 1/7206 0.0494032750487 ko04110 Cell cycle 2/356 145/7206 0.0494146193065