ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	191/1187	423/7206	8.53386825481e-47
ko04724	Glutamatergic synapse	82/1187	152/7206	1.03689360409e-26
ko05033	Nicotine addiction	44/1187	56/7206	1.2779777823e-24
ko05032	Morphine addiction	61/1187	110/7206	5.88271983061e-21
ko04713	Circadian entrainment	68/1187	136/7206	6.74102438526e-20
ko04727	GABAergic synapse	58/1187	110/7206	1.44921238942e-18
ko04721	Synaptic vesicle cycle	47/1187	80/7206	8.3940300889e-18
ko04728	Dopaminergic synapse	78/1187	185/7206	4.37553479346e-17
ko04020	Calcium signaling pathway	98/1187	265/7206	1.85494127143e-16
ko04024	cAMP signaling pathway	100/1187	279/7206	1.19758923691e-15
ko04725	Cholinergic synapse	67/1187	160/7206	1.16743351899e-14
ko04723	Retrograde endocannabinoid signaling	69/1187	175/7206	1.79324193863e-13
ko04726	Serotonergic synapse	58/1187	137/7206	4.23397242447e-13
ko04911	Insulin secretion	52/1187	117/7206	7.05731675387e-13
ko04921	Oxytocin signaling pathway	72/1187	209/7206	1.29679041445e-10
ko04970	Salivary secretion	41/1187	95/7206	5.98043767181e-10
ko03040	Spliceosome	2/1187	145/7206	2.51261992371e-09
ko03010	Ribosome	1/1187	129/7206	2.55943226755e-09
ko04742	Taste transduction	30/1187	61/7206	2.84757599289e-09
ko05031	Amphetamine addiction	38/1187	91/7206	7.81450583235e-09
ko04744	Phototransduction	21/1187	36/7206	1.37667235139e-08
ko04261	Adrenergic signaling in cardiomyocytes	64/1187	205/7206	1.44863734726e-07
ko04022	cGMP-PKG signaling pathway	66/1187	216/7206	1.87274202794e-07
ko05203	Viral carcinogenesis	17/1187	277/7206	2.2005765531e-07
ko05322	Systemic lupus erythematosus	5/1187	151/7206	5.90379263651e-07
ko04120	Ubiquitin mediated proteolysis	4/1187	138/7206	6.23019004174e-07
ko04621	NOD-like receptor signaling pathway	6/1187	157/7206	1.06174590628e-06
ko03013	RNA transport	7/1187	166/7206	1.2738347492e-06
ko04971	Gastric acid secretion	36/1187	98/7206	1.27966527461e-06
ko05164	Influenza A	7/1187	167/7206	1.29332859076e-06
ko04720	Long-term potentiation	36/1187	99/7206	1.5058771952e-06
ko05168	Herpes simplex infection	9/1187	182/7206	2.34718294258e-06
ko04972	Pancreatic secretion	38/1187	111/7206	3.76852741062e-06
ko04925	Aldosterone synthesis and secretion	36/1187	105/7206	6.99810573132e-06
ko04966	Collecting duct acid secretion	14/1187	26/7206	1.36349488981e-05
ko04070	Phosphatidylinositol signaling system	37/1187	112/7206	1.43947147095e-05
ko05030	Cocaine addiction	27/1187	73/7206	1.94493954642e-05
ko04110	Cell cycle	7/1187	145/7206	2.26919139034e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1187	74/7206	2.49825408347e-05
ko04924	Renin secretion	30/1187	86/7206	2.62859204282e-05
ko05162	Measles	5/1187	120/7206	5.23301705862e-05
ko05205	Proteoglycans in cancer	22/1187	271/7206	5.6331516721e-05
ko04360	Axon guidance	62/1187	233/7206	6.7599795649e-05
ko04141	Protein processing in endoplasmic reticulum	12/1187	184/7206	7.28640590283e-05
ko04730	Long-term depression	27/1187	78/7206	8.06829629755e-05
ko05166	HTLV-I infection	25/1187	292/7206	9.89790088361e-05
ko05169	Epstein-Barr virus infection	15/1187	206/7206	0.000120798013064
ko04540	Gap junction	38/1187	128/7206	0.000159000656614
ko03008	Ribosome biogenesis in eukaryotes	2/1187	79/7206	0.000173642344358
ko04740	Olfactory transduction	27/1187	80/7206	0.00018546689771
ko04976	Bile secretion	27/1187	80/7206	0.00018546689771
ko04060	Cytokine-cytokine receptor interaction	14/1187	191/7206	0.000229868281701
ko05161	Hepatitis B	12/1187	173/7206	0.000251575210014
ko04514	Cell adhesion molecules (CAMs)	38/1187	130/7206	0.000278953657766
ko04750	Inflammatory mediator regulation of TRP channels	36/1187	122/7206	0.000291835785543
ko04014	Ras signaling pathway	68/1187	279/7206	0.000518926409408
ko04745	Phototransduction - fly	15/1187	38/7206	0.000583368567223
ko04010	MAPK signaling pathway	76/1187	321/7206	0.00067014647758
ko00520	Amino sugar and nucleotide sugar metabolism	1/1187	55/7206	0.000853190232161
ko05110	Vibrio cholerae infection	21/1187	63/7206	0.000914727540139
ko04217	Necroptosis	14/1187	178/7206	0.000981865312765
ko04612	Antigen processing and presentation	3/1187	77/7206	0.0010237510628
ko04710	Circadian rhythm	16/1187	43/7206	0.00125730666189
ko04964	Proximal tubule bicarbonate reclamation	12/1187	29/7206	0.00126039088403
ko04630	Jak-STAT signaling pathway	9/1187	132/7206	0.00129790982926
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	24/1187	79/7206	0.00193992649336
ko04072	Phospholipase D signaling pathway	49/1187	197/7206	0.00237170666746
ko05219	Bladder cancer	1/1187	48/7206	0.0029148188183
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1187	182/7206	0.00322195718089
ko05145	Toxoplasmosis	9/1187	126/7206	0.00331369205897
ko04270	Vascular smooth muscle contraction	39/1187	154/7206	0.00417107286263
ko03420	Nucleotide excision repair	1/1187	46/7206	0.0044096137044
ko04626	Plant-pathogen interaction	8/1187	18/7206	0.00490208097176
ko04064	NF-kappa B signaling pathway	6/1187	96/7206	0.0050510865939
ko04260	Cardiac muscle contraction	27/1187	98/7206	0.00554277873749
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1187	100/7206	0.00644038709647
ko05414	Dilated cardiomyopathy	30/1187	112/7206	0.00645278508474
ko03022	Basal transcription factors	1/1187	44/7206	0.00672506190932
ko05140	Leishmaniasis	4/1187	75/7206	0.00696938413741
ko02010	ABC transporters	13/1187	39/7206	0.00832603772499
ko04330	Notch signaling pathway	3/1187	62/7206	0.0091894414052
ko04622	RIG-I-like receptor signaling pathway	3/1187	62/7206	0.0091894414052
ko05222	Small cell lung cancer	6/1187	89/7206	0.00931968199531
ko04214	Apoptosis - fly	4/1187	72/7206	0.00969237097257
ko04510	Focal adhesion	25/1187	240/7206	0.00996347980216
ko04218	Cellular senescence	17/1187	177/7206	0.0102237720449
ko05016	Huntington's disease	22/1187	215/7206	0.0114245551342
ko04658	Th1 and Th2 cell differentiation	7/1187	96/7206	0.0120949266595
ko04657	IL-17 signaling pathway	6/1187	87/7206	0.0127766761587
ko00562	Inositol phosphate metabolism	24/1187	89/7206	0.0134357021177
ko03410	Base excision repair	1/1187	38/7206	0.0147925505425
ko04930	Type II diabetes mellitus	16/1187	54/7206	0.0150780461498
ko04915	Estrogen signaling pathway	32/1187	131/7206	0.0171036111646
ko05220	Chronic myeloid leukemia	6/1187	85/7206	0.0175580622354
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1187	14/7206	0.0179488641068
ko04371	Apelin signaling pathway	41/1187	177/7206	0.0181764429969
ko01524	Platinum drug resistance	5/1187	76/7206	0.018484281418
ko05321	Inflammatory bowel disease (IBD)	3/1187	56/7206	0.0186383296446
ko04210	Apoptosis	18/1187	180/7206	0.0186953955252
ko04923	Regulation of lipolysis in adipocytes	21/1187	77/7206	0.0190494789492
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1187	59/7206	0.0199451477184
ko04620	Toll-like receptor signaling pathway	8/1187	100/7206	0.0202230770339
ko05200	Pathways in cancer	63/1187	492/7206	0.0232682747465
ko05131	Shigellosis	6/1187	82/7206	0.0236652459584
ko05212	Pancreatic cancer	6/1187	83/7206	0.024155803914
ko05144	Malaria	2/1187	45/7206	0.0253566402861
ko04115	p53 signaling pathway	5/1187	74/7206	0.0257638402663
ko00280	Valine, leucine and isoleucine degradation	3/1187	54/7206	0.0263300749137
ko05416	Viral myocarditis	3/1187	55/7206	0.0266996474149
ko04978	Mineral absorption	12/1187	40/7206	0.0302364998172
ko04140	Autophagy - animal	17/1187	164/7206	0.0328025654782
ko04550	Signaling pathways regulating pluripotency of stem cells	17/1187	165/7206	0.0330166134967
ko04113	Meiosis - yeast	5/1187	70/7206	0.0341979003635
ko04960	Aldosterone-regulated sodium reabsorption	12/1187	41/7206	0.034219602159
ko05215	Prostate cancer	10/1187	111/7206	0.037839957064
ko00010	Glycolysis / Gluconeogenesis	19/1187	74/7206	0.0396562697839
ko04922	Glucagon signaling pathway	30/1187	128/7206	0.0401160443777
ko05231	Choline metabolism in cancer	31/1187	134/7206	0.0447640954609
ko05202	Transcriptional misregulation in cancer	21/1187	188/7206	0.0463423125432
ko05217	Basal cell carcinoma	5/1187	68/7206	0.0468748367678
ko03015	mRNA surveillance pathway	8/1187	93/7206	0.0472510603028
ko04711	Circadian rhythm - fly	5/1187	13/7206	0.0487848136013
ko05340	Primary immunodeficiency	1/1187	30/7206	0.0490258844333