ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	220/1352	423/7206	2.636949563e-57
ko04724	Glutamatergic synapse	96/1352	152/7206	3.8923182833e-34
ko05033	Nicotine addiction	50/1352	56/7206	2.18348448687e-30
ko05032	Morphine addiction	74/1352	110/7206	3.67876324442e-29
ko04713	Circadian entrainment	84/1352	136/7206	5.97065266375e-29
ko04727	GABAergic synapse	71/1352	110/7206	2.48733098247e-26
ko04721	Synaptic vesicle cycle	55/1352	80/7206	1.16233456933e-22
ko04020	Calcium signaling pathway	116/1352	265/7206	1.98330383344e-21
ko04728	Dopaminergic synapse	91/1352	185/7206	2.02208763166e-21
ko04725	Cholinergic synapse	81/1352	160/7206	3.53807006305e-20
ko04024	cAMP signaling pathway	115/1352	279/7206	8.27532294033e-19
ko04723	Retrograde endocannabinoid signaling	82/1352	175/7206	9.26011332061e-18
ko04911	Insulin secretion	62/1352	117/7206	5.67776110832e-17
ko04726	Serotonergic synapse	68/1352	137/7206	1.52369504936e-16
ko04921	Oxytocin signaling pathway	89/1352	209/7206	7.26131520466e-16
ko04742	Taste transduction	40/1352	61/7206	1.03836921248e-15
ko04744	Phototransduction	29/1352	36/7206	1.39162545889e-15
ko04970	Salivary secretion	50/1352	95/7206	8.89889525965e-14
ko04720	Long-term potentiation	51/1352	99/7206	1.53380713846e-13
ko05031	Amphetamine addiction	47/1352	91/7206	1.2371576589e-12
ko03040	Spliceosome	1/1352	145/7206	3.30797556521e-12
ko04740	Olfactory transduction	42/1352	80/7206	9.81201086127e-12
ko04261	Adrenergic signaling in cardiomyocytes	78/1352	205/7206	6.57232197013e-11
ko04925	Aldosterone synthesis and secretion	47/1352	105/7206	9.92339513907e-10
ko04022	cGMP-PKG signaling pathway	77/1352	216/7206	2.59759942345e-09
ko04971	Gastric acid secretion	44/1352	98/7206	3.45025996725e-09
ko05203	Viral carcinogenesis	18/1352	277/7206	3.93035677064e-09
ko04360	Axon guidance	80/1352	233/7206	1.01413163942e-08
ko05168	Herpes simplex infection	8/1352	182/7206	1.22291611085e-08
ko04540	Gap junction	51/1352	128/7206	2.87178506176e-08
ko03013	RNA transport	7/1352	166/7206	3.11208193873e-08
ko04730	Long-term depression	34/1352	78/7206	4.39694828015e-07
ko05322	Systemic lupus erythematosus	7/1352	151/7206	4.47017608169e-07
ko04060	Cytokine-cytokine receptor interaction	12/1352	191/7206	7.6832901828e-07
ko05030	Cocaine addiction	32/1352	73/7206	9.11620424721e-07
ko04966	Collecting duct acid secretion	16/1352	26/7206	1.71452444654e-06
ko04972	Pancreatic secretion	42/1352	111/7206	1.92868591867e-06
ko04924	Renin secretion	35/1352	86/7206	2.06278006341e-06
ko05164	Influenza A	10/1352	167/7206	2.77308752594e-06
ko04070	Phosphatidylinositol signaling system	42/1352	112/7206	3.62424751567e-06
ko04141	Protein processing in endoplasmic reticulum	13/1352	184/7206	8.39467354076e-06
ko04621	NOD-like receptor signaling pathway	10/1352	157/7206	1.09770500573e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	26/1352	59/7206	1.1122461464e-05
ko04745	Phototransduction - fly	19/1352	38/7206	1.27024426807e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1352	74/7206	1.38943610808e-05
ko04010	MAPK signaling pathway	91/1352	321/7206	1.95370610147e-05
ko05169	Epstein-Barr virus infection	17/1352	206/7206	2.66981780643e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1352	79/7206	2.88959099985e-05
ko04976	Bile secretion	31/1352	80/7206	3.23316718157e-05
ko04750	Inflammatory mediator regulation of TRP channels	42/1352	122/7206	3.2603887991e-05
ko04514	Cell adhesion molecules (CAMs)	44/1352	130/7206	3.49042554003e-05
ko04120	Ubiquitin mediated proteolysis	9/1352	138/7206	5.87968382294e-05
ko04964	Proximal tubule bicarbonate reclamation	15/1352	29/7206	6.35781033648e-05
ko04260	Cardiac muscle contraction	35/1352	98/7206	6.69144000699e-05
ko04371	Apelin signaling pathway	55/1352	177/7206	8.02806708718e-05
ko04626	Plant-pathogen interaction	11/1352	18/7206	8.46251652606e-05
ko05110	Vibrio cholerae infection	25/1352	63/7206	0.000115520084747
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1352	79/7206	0.000206269168939
ko04110	Cell cycle	11/1352	145/7206	0.000220033216161
ko05162	Measles	8/1352	120/7206	0.00022021673999
ko04014	Ras signaling pathway	77/1352	279/7206	0.000222655923602
ko04072	Phospholipase D signaling pathway	58/1352	197/7206	0.000272687123219
ko05414	Dilated cardiomyopathy	37/1352	112/7206	0.000327622872194
ko04146	Peroxisome	5/1352	89/7206	0.000539442923685
ko04923	Regulation of lipolysis in adipocytes	27/1352	77/7206	0.000613481362117
ko04064	NF-kappa B signaling pathway	6/1352	96/7206	0.000837749177941
ko04915	Estrogen signaling pathway	40/1352	131/7206	0.000971718274585
ko04612	Antigen processing and presentation	4/1352	77/7206	0.00102667368157
ko05205	Proteoglycans in cancer	31/1352	271/7206	0.00111096826167
ko00240	Pyrimidine metabolism	8/1352	110/7206	0.00119390411696
ko05140	Leishmaniasis	4/1352	75/7206	0.00149384857435
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1352	14/7206	0.00153736774737
ko00520	Amino sugar and nucleotide sugar metabolism	2/1352	55/7206	0.00155159429891
ko00480	Glutathione metabolism	2/1352	55/7206	0.00155159429891
ko03022	Basal transcription factors	1/1352	44/7206	0.00169758886947
ko05144	Malaria	1/1352	45/7206	0.00169828902702
ko00071	Fatty acid degradation	1/1352	45/7206	0.00169828902702
ko03420	Nucleotide excision repair	1/1352	46/7206	0.00179497252961
ko04214	Apoptosis - fly	4/1352	72/7206	0.00210235587893
ko05145	Toxoplasmosis	11/1352	126/7206	0.00254842009648
ko04622	RIG-I-like receptor signaling pathway	3/1352	62/7206	0.00277621442112
ko04610	Complement and coagulation cascades	5/1352	79/7206	0.00326514606308
ko04912	GnRH signaling pathway	36/1352	122/7206	0.00334671208731
ko03018	RNA degradation	6/1352	84/7206	0.00445538600566
ko04270	Vascular smooth muscle contraction	43/1352	154/7206	0.00470383506459
ko04918	Thyroid hormone synthesis	27/1352	86/7206	0.00491522454566
ko04922	Glucagon signaling pathway	37/1352	128/7206	0.00571237179179
ko05166	HTLV-I infection	37/1352	292/7206	0.00575153625163
ko05321	Inflammatory bowel disease (IBD)	3/1352	56/7206	0.00577519740247
ko00630	Glyoxylate and dicarboxylate metabolism	1/1352	38/7206	0.00591005805961
ko00310	Lysine degradation	5/1352	73/7206	0.00620107035497
ko05131	Shigellosis	6/1352	82/7206	0.00623864895005
ko04115	p53 signaling pathway	5/1352	74/7206	0.00634341806831
ko05161	Hepatitis B	19/1352	173/7206	0.00746542159485
ko04658	Th1 and Th2 cell differentiation	8/1352	96/7206	0.0078427942897
ko04657	IL-17 signaling pathway	7/1352	87/7206	0.00811025892254
ko05133	Pertussis	7/1352	87/7206	0.00811025892254
ko04620	Toll-like receptor signaling pathway	9/1352	100/7206	0.00952468434394
ko01524	Platinum drug resistance	6/1352	76/7206	0.0116157381732
ko04210	Apoptosis	21/1352	180/7206	0.0117930196266
ko00590	Arachidonic acid metabolism	3/1352	52/7206	0.0119253706227
ko04916	Melanogenesis	39/1352	142/7206	0.0120001704759
ko04668	TNF signaling pathway	12/1352	120/7206	0.0126972289317
ko05132	Salmonella infection	9/1352	98/7206	0.0127672282378
ko05231	Choline metabolism in cancer	37/1352	134/7206	0.0134125089972
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1352	100/7206	0.0134611852737
ko05222	Small cell lung cancer	8/1352	89/7206	0.0138674973554
ko04217	Necroptosis	21/1352	178/7206	0.0148182070272
ko04015	Rap1 signaling pathway	68/1352	278/7206	0.0151127686785
ko00562	Inositol phosphate metabolism	26/1352	89/7206	0.0191334851313
ko04932	Non-alcoholic fatty liver disease (NAFLD)	22/1352	182/7206	0.0205205871737
ko00290	Valine, leucine and isoleucine biosynthesis	3/1352	4/7206	0.0226667252048
ko05418	Fluid shear stress and atherosclerosis	21/1352	173/7206	0.0231025634605
ko04640	Hematopoietic cell lineage	5/1352	64/7206	0.0232427722555
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1352	40/7206	0.0236339851573
ko04973	Carbohydrate digestion and absorption	14/1352	42/7206	0.0264859806231
ko05215	Prostate cancer	12/1352	111/7206	0.0275611727057
ko05214	Glioma	23/1352	79/7206	0.0282997684094
ko05320	Autoimmune thyroid disease	1/1352	29/7206	0.0306560985084
ko04630	Jak-STAT signaling pathway	15/1352	132/7206	0.0316910902303
ko00330	Arginine and proline metabolism	5/1352	61/7206	0.0317725700403
ko00280	Valine, leucine and isoleucine degradation	4/1352	54/7206	0.0340157003017
ko00982	Drug metabolism - cytochrome P450	2/1352	37/7206	0.0340718180066
ko03410	Base excision repair	2/1352	38/7206	0.0346629542135
ko04978	Mineral absorption	13/1352	40/7206	0.0392085270757
ko05217	Basal cell carcinoma	6/1352	68/7206	0.0407271628442
ko04350	TGF-beta signaling pathway	11/1352	103/7206	0.0407661293551
ko04960	Aldosterone-regulated sodium reabsorption	13/1352	41/7206	0.0431871301554
ko01212	Fatty acid metabolism	5/1352	60/7206	0.0443125912443