ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 38/361 152/7206 3.28280779279e-17 ko04020 Calcium signaling pathway 43/361 265/7206 3.44859779917e-12 ko04911 Insulin secretion 26/361 117/7206 7.15213078306e-11 ko04713 Circadian entrainment 28/361 136/7206 8.91451793518e-11 ko04728 Dopaminergic synapse 32/361 185/7206 4.5594997656e-10 ko04925 Aldosterone synthesis and secretion 22/361 105/7206 7.01763008818e-09 ko04720 Long-term potentiation 21/361 99/7206 1.23490327663e-08 ko05031 Amphetamine addiction 20/361 91/7206 1.45689045139e-08 ko04727 GABAergic synapse 22/361 110/7206 1.73942735695e-08 ko05032 Morphine addiction 22/361 110/7206 1.73942735695e-08 ko05030 Cocaine addiction 17/361 73/7206 7.28551591434e-08 ko04725 Cholinergic synapse 26/361 160/7206 7.88464858643e-08 ko04723 Retrograde endocannabinoid signaling 27/361 175/7206 1.3344085099e-07 ko04022 cGMP-PKG signaling pathway 30/361 216/7206 2.88386568975e-07 ko04024 cAMP signaling pathway 35/361 279/7206 3.63265660306e-07 ko04080 Neuroactive ligand-receptor interaction 46/361 423/7206 4.19159249267e-07 ko04261 Adrenergic signaling in cardiomyocytes 28/361 205/7206 1.03052547439e-06 ko04072 Phospholipase D signaling pathway 27/361 197/7206 1.51064831762e-06 ko04912 GnRH signaling pathway 20/361 122/7206 2.24421341993e-06 ko05033 Nicotine addiction 13/361 56/7206 2.67826297623e-06 ko04915 Estrogen signaling pathway 20/361 131/7206 6.92675727039e-06 ko04070 Phosphatidylinositol signaling system 18/361 112/7206 9.65939909502e-06 ko04970 Salivary secretion 16/361 95/7206 1.65119550749e-05 ko04971 Gastric acid secretion 16/361 98/7206 2.47078229929e-05 ko04742 Taste transduction 12/361 61/7206 3.90765009155e-05 ko04972 Pancreatic secretion 16/361 111/7206 0.000117108607037 ko04211 Longevity regulating pathway 17/361 123/7206 0.000122806865656 ko04921 Oxytocin signaling pathway 24/361 209/7206 0.000130987892386 ko04918 Thyroid hormone synthesis 13/361 86/7206 0.000314706385908 ko04923 Regulation of lipolysis in adipocytes 12/361 77/7206 0.000399549455505 ko04726 Serotonergic synapse 17/361 137/7206 0.000456871526616 ko04062 Chemokine signaling pathway 22/361 201/7206 0.000456918382364 ko04740 Olfactory transduction 12/361 80/7206 0.000572064054506 ko04371 Apelin signaling pathway 20/361 177/7206 0.000615280673187 ko04540 Gap junction 16/361 128/7206 0.000615427362937 ko04914 Progesterone-mediated oocyte maturation 14/361 104/7206 0.000633146099603 ko04060 Cytokine-cytokine receptor interaction 1/361 191/7206 0.00108455093788 ko04213 Longevity regulating pathway - multiple species 12/361 86/7206 0.00110783469884 ko05168 Herpes simplex infection 1/361 182/7206 0.00157007189832 ko04270 Vascular smooth muscle contraction 17/361 154/7206 0.00206049875372 ko00510 N-Glycan biosynthesis 8/361 50/7206 0.00310347156597 ko04360 Axon guidance 22/361 233/7206 0.00348067865717 ko04010 MAPK signaling pathway 28/361 321/7206 0.0036666735058 ko05231 Choline metabolism in cancer 15/361 134/7206 0.00372114043353 ko04320 Dorso-ventral axis formation 6/361 31/7206 0.0038442940482 ko00513 Various types of N-glycan biosynthesis 7/361 42/7206 0.00441285275982 ko00562 Inositol phosphate metabolism 11/361 89/7206 0.00465301305852 ko04114 Oocyte meiosis 15/361 139/7206 0.00467150227862 ko04750 Inflammatory mediator regulation of TRP channels 14/361 122/7206 0.00480111244068 ko04916 Melanogenesis 15/361 142/7206 0.00544296858317 ko05202 Transcriptional misregulation in cancer 2/361 188/7206 0.00616280282908 ko00515 Mannose type O-glycan biosynthesis 5/361 25/7206 0.00710695761878 ko05034 Alcoholism 21/361 238/7206 0.00981316634068 ko04924 Renin secretion 10/361 86/7206 0.0104162598158 ko05203 Viral carcinogenesis 5/361 277/7206 0.0104984993062 ko04110 Cell cycle 1/361 145/7206 0.0105765639963 ko04745 Phototransduction - fly 6/361 38/7206 0.0107387409734 ko05213 Endometrial cancer 8/361 62/7206 0.0116174869856 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 5/361 28/7206 0.0116261895995 ko04012 ErbB signaling pathway 12/361 109/7206 0.0116274272144 ko04922 Glucagon signaling pathway 13/361 128/7206 0.0128309713367 ko05414 Dilated cardiomyopathy 12/361 112/7206 0.0130008759731 ko04015 Rap1 signaling pathway 23/361 278/7206 0.016326075014 ko04722 Neurotrophin signaling pathway 15/361 160/7206 0.016329444804 ko04014 Ras signaling pathway 23/361 279/7206 0.0166589756761 ko05214 Glioma 9/361 79/7206 0.0166924236583 ko04930 Type II diabetes mellitus 7/361 54/7206 0.0173608828226 ko04145 Phagosome 2/361 162/7206 0.0174861950826 ko04976 Bile secretion 9/361 80/7206 0.0180085052425 ko04144 Endocytosis 27/361 342/7206 0.0211109538033 ko00190 Oxidative phosphorylation 1/361 127/7206 0.0216136131573 ko00564 Glycerophospholipid metabolism 10/361 99/7206 0.0318715531494 ko01522 Endocrine resistance 12/361 124/7206 0.0334602299627 ko04139 Mitophagy - yeast 5/361 37/7206 0.0357808370257 ko04913 Ovarian steroidogenesis 7/361 63/7206 0.0370853798843 ko00561 Glycerolipid metabolism 7/361 63/7206 0.0370853798843 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 4/361 26/7206 0.0386819958661 ko04611 Platelet activation 14/361 163/7206 0.0437160099689 ko00240 Pyrimidine metabolism 1/361 110/7206 0.0445451609314 ko05223 Non-small cell lung cancer 7/361 66/7206 0.0460256039267 ko04011 MAPK signaling pathway - yeast 6/361 53/7206 0.0479093549777