ko pathway ratio_in_study ratio_in_pop p_value ko05321 Inflammatory bowel disease (IBD) 14/348 56/7206 2.64135833038e-07 ko05164 Influenza A 24/348 167/7206 1.30933366675e-06 ko04621 NOD-like receptor signaling pathway 23/348 157/7206 1.55798731162e-06 ko05340 Primary immunodeficiency 9/348 30/7206 7.47671154228e-06 ko04060 Cytokine-cytokine receptor interaction 24/348 191/7206 1.41799471086e-05 ko05162 Measles 18/348 120/7206 1.55947474773e-05 ko04630 Jak-STAT signaling pathway 19/348 132/7206 1.66047071492e-05 ko05168 Herpes simplex infection 23/348 182/7206 1.95425909131e-05 ko00120 Primary bile acid biosynthesis 7/348 20/7206 2.59041507321e-05 ko05152 Tuberculosis 23/348 187/7206 3.03858691303e-05 ko04650 Natural killer cell mediated cytotoxicity 15/348 97/7206 5.56800965565e-05 ko04380 Osteoclast differentiation 18/348 134/7206 7.0804144735e-05 ko04620 Toll-like receptor signaling pathway 15/348 100/7206 7.98765523721e-05 ko05145 Toxoplasmosis 17/348 126/7206 0.000106214929363 ko04658 Th1 and Th2 cell differentiation 14/348 96/7206 0.000187363404646 ko04064 NF-kappa B signaling pathway 14/348 96/7206 0.000187363404646 ko04668 TNF signaling pathway 16/348 120/7206 0.000194420313828 ko05140 Leishmaniasis 12/348 75/7206 0.000221480275992 ko04217 Necroptosis 20/348 178/7206 0.000478784576591 ko04659 Th17 cell differentiation 14/348 106/7206 0.000534141639167 ko04710 Circadian rhythm 8/348 43/7206 0.000896005335741 ko05167 Kaposi's sarcoma-associated herpesvirus infection 20/348 191/7206 0.000929280573212 ko04662 B cell receptor signaling pathway 12/348 88/7206 0.000990018260804 ko05150 Staphylococcus aureus infection 7/348 36/7206 0.00142961396865 ko00592 alpha-Linolenic acid metabolism 5/348 19/7206 0.00169255104589 ko04137 Mitophagy - animal 11/348 82/7206 0.0018253008709 ko04664 Fc epsilon RI signaling pathway 10/348 77/7206 0.0037020685641 ko04610 Complement and coagulation cascades 10/348 79/7206 0.00446483770112 ko05330 Allograft rejection 5/348 24/7206 0.00507175320967 ko05161 Hepatitis B 17/348 173/7206 0.0057512838298 ko04210 Apoptosis 17/348 180/7206 0.00726691940388 ko04672 Intestinal immune network for IgA production 6/348 37/7206 0.00793155256782 ko04611 Platelet activation 16/348 163/7206 0.00796026181625 ko05133 Pertussis 10/348 87/7206 0.00882550845485 ko05134 Legionellosis 9/348 74/7206 0.00887946433261 ko04622 RIG-I-like receptor signaling pathway 8/348 62/7206 0.00942736329666 ko05332 Graft-versus-host disease 4/348 18/7206 0.00954413710108 ko04110 Cell cycle 1/348 145/7206 0.010210663263 ko04146 Peroxisome 10/348 89/7206 0.010305680165 ko05323 Rheumatoid arthritis 10/348 89/7206 0.010305680165 ko00950 Isoquinoline alkaloid biosynthesis 3/348 10/7206 0.0103960064728 ko05160 Hepatitis C 15/348 153/7206 0.0110930129826 ko04612 Antigen processing and presentation 9/348 77/7206 0.0114256876587 ko05320 Autoimmune thyroid disease 5/348 29/7206 0.0116315401687 ko00590 Arachidonic acid metabolism 7/348 52/7206 0.0118383744718 ko00140 Steroid hormone biosynthesis 6/348 41/7206 0.0130546126083 ko00051 Fructose and mannose metabolism 6/348 42/7206 0.0146298488368 ko04723 Retrograde endocannabinoid signaling 2/348 175/7206 0.0181963495098 ko04660 T cell receptor signaling pathway 12/348 124/7206 0.0183312156951 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/348 5/7206 0.0211035157179 ko04540 Gap junction 1/348 128/7206 0.0213611589704 ko03010 Ribosome 1/348 129/7206 0.0213801924637 ko00220 Arginine biosynthesis 4/348 24/7206 0.0264056340753 ko00330 Arginine and proline metabolism 7/348 61/7206 0.0267358531682 ko00362 Benzoate degradation 2/348 6/7206 0.0306540426042 ko04390 Hippo signaling pathway 3/348 188/7206 0.0362344216376 ko04145 Phagosome 14/348 162/7206 0.0378581966256 ko05222 Small cell lung cancer 9/348 89/7206 0.039134759821 ko04931 Insulin resistance 12/348 137/7206 0.0412522673601 ko04972 Pancreatic secretion 1/348 111/7206 0.0443110247456 ko05034 Alcoholism 5/348 238/7206 0.0445534113381 ko05310 Asthma 3/348 17/7206 0.0458966012329 ko00360 Phenylalanine metabolism 3/348 17/7206 0.0458966012329 ko04960 Aldosterone-regulated sodium reabsorption 5/348 41/7206 0.045960057443 ko03040 Spliceosome 2/348 145/7206 0.0485199612541 ko04666 Fc gamma R-mediated phagocytosis 11/348 122/7206 0.0497321284119