ko pathway ratio_in_study ratio_in_pop p_value ko04621 NOD-like receptor signaling pathway 32/329 157/7206 3.92903608492e-13 ko04060 Cytokine-cytokine receptor interaction 35/329 191/7206 8.05049347378e-13 ko05340 Primary immunodeficiency 14/329 30/7206 9.7602744139e-12 ko05145 Toxoplasmosis 26/329 126/7206 5.2188500212e-11 ko05164 Influenza A 30/329 167/7206 6.44398656583e-11 ko05162 Measles 25/329 120/7206 1.00049829173e-10 ko04650 Natural killer cell mediated cytotoxicity 22/329 97/7206 2.43925861426e-10 ko04612 Antigen processing and presentation 19/329 77/7206 9.16235231206e-10 ko04659 Th17 cell differentiation 22/329 106/7206 1.49276114595e-09 ko04217 Necroptosis 29/329 178/7206 1.51410938748e-09 ko05168 Herpes simplex infection 28/329 182/7206 1.10012384814e-08 ko04380 Osteoclast differentiation 23/329 134/7206 2.93664981174e-08 ko05330 Allograft rejection 10/329 24/7206 3.8068268391e-08 ko04658 Th1 and Th2 cell differentiation 19/329 96/7206 4.57375212038e-08 ko05321 Inflammatory bowel disease (IBD) 14/329 56/7206 1.3193660769e-07 ko05140 Leishmaniasis 16/329 75/7206 1.81694072235e-07 ko04064 NF-kappa B signaling pathway 18/329 96/7206 2.4713754528e-07 ko05152 Tuberculosis 26/329 187/7206 3.0246038661e-07 ko05320 Autoimmune thyroid disease 10/329 29/7206 3.16765739106e-07 ko04630 Jak-STAT signaling pathway 21/329 132/7206 4.52404118778e-07 ko04620 Toll-like receptor signaling pathway 18/329 100/7206 4.68717914206e-07 ko05332 Graft-versus-host disease 8/329 18/7206 5.08364245909e-07 ko04622 RIG-I-like receptor signaling pathway 13/329 62/7206 3.2322351333e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/329 191/7206 5.4558401378e-06 ko04660 T cell receptor signaling pathway 18/329 124/7206 1.15061812183e-05 ko05150 Staphylococcus aureus infection 9/329 36/7206 2.43608597868e-05 ko04672 Intestinal immune network for IgA production 9/329 37/7206 3.09146016784e-05 ko05133 Pertussis 14/329 87/7206 3.39463006481e-05 ko04062 Chemokine signaling pathway 23/329 201/7206 3.98835194849e-05 ko04940 Type I diabetes mellitus 8/329 32/7206 6.96448072237e-05 ko05310 Asthma 6/329 17/7206 6.98169649369e-05 ko04623 Cytosolic DNA-sensing pathway 9/329 41/7206 7.4063405654e-05 ko05161 Hepatitis B 20/329 173/7206 0.00011053626646 ko04640 Hematopoietic cell lineage 11/329 64/7206 0.000128500306978 ko03050 Proteasome 10/329 54/7206 0.000136488466805 ko04662 B cell receptor signaling pathway 13/329 88/7206 0.000159585003666 ko04145 Phagosome 18/329 162/7206 0.000397774368371 ko05323 Rheumatoid arthritis 12/329 89/7206 0.000669212503403 ko04664 Fc epsilon RI signaling pathway 11/329 77/7206 0.000679451344693 ko00120 Primary bile acid biosynthesis 5/329 20/7206 0.00169114074722 ko00590 Arachidonic acid metabolism 8/329 52/7206 0.00224729279753 ko05160 Hepatitis C 16/329 153/7206 0.00231344391284 ko05142 Chagas disease (American trypanosomiasis) 14/329 130/7206 0.00232733748307 ko05416 Viral myocarditis 8/329 55/7206 0.00322918156901 ko04310 Wnt signaling pathway 1/329 181/7206 0.00335760306392 ko04611 Platelet activation 16/329 163/7206 0.0034952502595 ko04666 Fc gamma R-mediated phagocytosis 13/329 122/7206 0.00361700964653 ko04080 Neuroactive ligand-receptor interaction 8/329 423/7206 0.00380032997215 ko05144 Malaria 7/329 45/7206 0.00393690587154 ko00511 Other glycan degradation 5/329 26/7206 0.00573003140195 ko05010 Alzheimer's disease 2/329 202/7206 0.00906491540438 ko04142 Lysosome 14/329 151/7206 0.00968949029945 ko04210 Apoptosis 16/329 180/7206 0.00992137787528 ko05034 Alcoholism 3/329 238/7206 0.0102453299724 ko04668 TNF signaling pathway 12/329 120/7206 0.0119100511411 ko04390 Hippo signaling pathway 2/329 188/7206 0.0124807919475 ko04530 Tight junction 3/329 228/7206 0.0140789835872 ko03040 Spliceosome 1/329 145/7206 0.0148694493722 ko05169 Epstein-Barr virus infection 17/329 206/7206 0.0164148446619 ko04514 Cell adhesion molecules (CAMs) 12/329 130/7206 0.0175232460821 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/329 5/7206 0.018960984333 ko00220 Arginine biosynthesis 4/329 24/7206 0.0219855442853 ko04916 Melanogenesis 1/329 142/7206 0.0224256060137 ko05224 Breast cancer 2/329 174/7206 0.0251968167188 ko04723 Retrograde endocannabinoid signaling 2/329 175/7206 0.025402111294 ko04610 Complement and coagulation cascades 8/329 79/7206 0.0270065085463 ko00190 Oxidative phosphorylation 1/329 127/7206 0.0309498287691 ko04137 Mitophagy - animal 8/329 82/7206 0.0328394372242 ko04360 Axon guidance 4/329 233/7206 0.0358749822287 ko00140 Steroid hormone biosynthesis 5/329 41/7206 0.0374845071942 ko00051 Fructose and mannose metabolism 5/329 42/7206 0.0410217243068 ko00983 Drug metabolism - other enzymes 5/329 42/7206 0.0410217243068 ko05132 Salmonella infection 9/329 98/7206 0.0442923093507 ko04911 Insulin secretion 1/329 117/7206 0.0445233581356 ko04728 Dopaminergic synapse 3/329 185/7206 0.0488742516235