ko pathway ratio_in_study ratio_in_pop p_value ko04610 Complement and coagulation cascades 39/345 79/7206 3.89240452078e-31 ko04975 Fat digestion and absorption 15/345 35/7206 1.59944914304e-11 ko04974 Protein digestion and absorption 20/345 96/7206 1.78121082911e-08 ko04977 Vitamin digestion and absorption 10/345 22/7206 2.14984555104e-08 ko00260 Glycine, serine and threonine metabolism 14/345 48/7206 2.79961023388e-08 ko01200 Carbon metabolism 23/345 128/7206 2.91835177896e-08 ko05150 Staphylococcus aureus infection 12/345 36/7206 5.30392729177e-08 ko04978 Mineral absorption 12/345 40/7206 1.98941914663e-07 ko00983 Drug metabolism - other enzymes 11/345 42/7206 2.90152797738e-06 ko01230 Biosynthesis of amino acids 15/345 85/7206 9.895090102e-06 ko04614 Renin-angiotensin system 7/345 18/7206 1.0926335139e-05 ko00040 Pentose and glucuronate interconversions 8/345 26/7206 1.86173858402e-05 ko03320 PPAR signaling pathway 13/345 69/7206 1.87294727756e-05 ko04976 Bile secretion 14/345 80/7206 2.16359254572e-05 ko00010 Glycolysis / Gluconeogenesis 13/345 74/7206 4.08152097837e-05 ko04950 Maturity onset diabetes of the young 8/345 29/7206 4.50759247518e-05 ko00330 Arginine and proline metabolism 11/345 61/7206 0.000124999093104 ko05200 Pathways in cancer 8/345 492/7206 0.000177900107119 ko04360 Axon guidance 1/345 233/7206 0.000235505179478 ko04972 Pancreatic secretion 15/345 111/7206 0.000240534359308 ko00270 Cysteine and methionine metabolism 9/345 47/7206 0.000322375845783 ko00630 Glyoxylate and dicarboxylate metabolism 8/345 38/7206 0.000351935185031 ko00980 Metabolism of xenobiotics by cytochrome P450 8/345 40/7206 0.000508991097839 ko05166 HTLV-I infection 3/345 292/7206 0.000640034046631 ko04010 MAPK signaling pathway 4/345 321/7206 0.000731953227515 ko00680 Methane metabolism 7/345 34/7206 0.000951335109421 ko00472 D-Arginine and D-ornithine metabolism 3/345 5/7206 0.0010123080172 ko00311 Penicillin and cephalosporin biosynthesis 3/345 5/7206 0.0010123080172 ko04146 Peroxisome 12/345 89/7206 0.0010163050715 ko05034 Alcoholism 2/345 238/7206 0.0010352753765 ko00500 Starch and sucrose metabolism 7/345 35/7206 0.00114114935426 ko00710 Carbon fixation in photosynthetic organisms 6/345 27/7206 0.00144997063623 ko04390 Hippo signaling pathway 1/345 188/7206 0.00156466438323 ko04144 Endocytosis 5/345 342/7206 0.00158919651602 ko04080 Neuroactive ligand-receptor interaction 8/345 423/7206 0.00211496829997 ko04310 Wnt signaling pathway 1/345 181/7206 0.00229161427856 ko00380 Tryptophan metabolism 8/345 50/7206 0.00234129853031 ko00100 Steroid biosynthesis 5/345 21/7206 0.00263357128616 ko05133 Pertussis 11/345 87/7206 0.00275347441216 ko00140 Steroid hormone biosynthesis 7/345 41/7206 0.00298121794743 ko00591 Linoleic acid metabolism 5/345 22/7206 0.00327647962714 ko00051 Fructose and mannose metabolism 7/345 42/7206 0.00343376134538 ko04973 Carbohydrate digestion and absorption 7/345 42/7206 0.00343376134538 ko00830 Retinol metabolism 7/345 42/7206 0.00343376134538 ko00030 Pentose phosphate pathway 6/345 32/7206 0.00362732443113 ko00520 Amino sugar and nucleotide sugar metabolism 8/345 55/7206 0.00431432677094 ko05169 Epstein-Barr virus infection 2/345 206/7206 0.00435793887221 ko04216 Ferroptosis 7/345 44/7206 0.00449386638166 ko04922 Glucagon signaling pathway 14/345 128/7206 0.00488030965093 ko03013 RNA transport 1/345 166/7206 0.00491326780398 ko04621 NOD-like receptor signaling pathway 1/345 157/7206 0.00710395668959 ko05204 Chemical carcinogenesis 7/345 48/7206 0.00733295415068 ko00360 Phenylalanine metabolism 4/345 17/7206 0.00748093280194 ko00250 Alanine, aspartate and glutamate metabolism 6/345 38/7206 0.0086843208034 ko02010 ABC transporters 6/345 39/7206 0.00986072693581 ko04964 Proximal tubule bicarbonate reclamation 5/345 29/7206 0.0112300943174 ko04141 Protein processing in endoplasmic reticulum 2/345 184/7206 0.0127623373661 ko04152 AMPK signaling pathway 15/345 161/7206 0.0131670955088 ko00120 Primary bile acid biosynthesis 4/345 20/7206 0.0135996429669 ko00480 Glutathione metabolism 7/345 55/7206 0.0152046961263 ko00053 Ascorbate and aldarate metabolism 4/345 22/7206 0.0190473207937 ko00052 Galactose metabolism 5/345 33/7206 0.0192092164666 ko00232 Caffeine metabolism 2/345 5/7206 0.0207584109531 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/345 5/7206 0.0207584109531 ko00620 Pyruvate metabolism 6/345 46/7206 0.0214200599289 ko00860 Porphyrin and chlorophyll metabolism 5/345 34/7206 0.0216647520253 ko00020 Citrate cycle (TCA cycle) 5/345 35/7206 0.0243157626403 ko00220 Arginine biosynthesis 4/345 24/7206 0.0256742084813 ko00770 Pantothenate and CoA biosynthesis 3/345 14/7206 0.0267165070333 ko04062 Chemokine signaling pathway 3/345 201/7206 0.0270380892297 ko00340 Histidine metabolism 4/345 25/7206 0.0294454352243 ko00982 Drug metabolism - cytochrome P450 5/345 37/7206 0.0302223867605 ko05162 Measles 1/345 120/7206 0.0308436933547 ko04666 Fc gamma R-mediated phagocytosis 1/345 122/7206 0.0308751575236 ko04660 T cell receptor signaling pathway 1/345 124/7206 0.031181770716 ko04015 Rap1 signaling pathway 6/345 278/7206 0.0313712832593 ko04728 Dopaminergic synapse 3/345 185/7206 0.0356116959321 ko04725 Cholinergic synapse 2/345 160/7206 0.0361091702738 ko00590 Arachidonic acid metabolism 6/345 52/7206 0.0367224825519 ko04931 Insulin resistance 12/345 137/7206 0.0398911133735 ko05020 Prion diseases 5/345 40/7206 0.040647665029 ko04013 MAPK signaling pathway - fly 1/345 115/7206 0.0446887932144 ko00720 Carbon fixation pathways in prokaryotes 3/345 17/7206 0.0449127438803 ko04921 Oxytocin signaling pathway 4/345 209/7206 0.0472291288187 ko00401 Novobiocin biosynthesis 1/345 1/7206 0.047876769359 ko04217 Necroptosis 3/345 178/7206 0.0489017205773