ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	200/1145	423/7206	7.33321089977e-56
ko04724	Glutamatergic synapse	93/1145	152/7206	1.37316104388e-37
ko05033	Nicotine addiction	49/1145	56/7206	2.20746687555e-32
ko05032	Morphine addiction	68/1145	110/7206	4.44276731384e-28
ko04713	Circadian entrainment	77/1145	136/7206	4.69861015036e-28
ko04727	GABAergic synapse	66/1145	110/7206	3.36468198005e-26
ko04721	Synaptic vesicle cycle	52/1145	80/7206	3.26822707276e-23
ko04725	Cholinergic synapse	78/1145	160/7206	8.37239733302e-23
ko04728	Dopaminergic synapse	85/1145	185/7206	1.45899618853e-22
ko04723	Retrograde endocannabinoid signaling	79/1145	175/7206	1.90861410053e-20
ko04024	cAMP signaling pathway	105/1145	279/7206	2.0572301461e-19
ko04020	Calcium signaling pathway	99/1145	265/7206	4.16951388755e-18
ko04911	Insulin secretion	57/1145	117/7206	6.06755447054e-17
ko04921	Oxytocin signaling pathway	82/1145	209/7206	1.21941277963e-16
ko04726	Serotonergic synapse	61/1145	137/7206	1.08850834089e-15
ko04742	Taste transduction	37/1145	61/7206	1.99547609598e-15
ko04720	Long-term potentiation	47/1145	99/7206	1.1819647073e-13
ko04744	Phototransduction	25/1145	36/7206	8.59757089831e-13
ko05031	Amphetamine addiction	43/1145	91/7206	1.63004477066e-12
ko04261	Adrenergic signaling in cardiomyocytes	70/1145	205/7206	7.87953093146e-11
ko04970	Salivary secretion	41/1145	95/7206	1.91369792721e-10
ko03040	Spliceosome	1/1145	145/7206	5.15735288073e-10
ko04925	Aldosterone synthesis and secretion	41/1145	105/7206	7.13746482781e-09
ko04971	Gastric acid secretion	39/1145	98/7206	8.87313743658e-09
ko05168	Herpes simplex infection	6/1145	182/7206	8.40386160217e-08
ko05203	Viral carcinogenesis	15/1145	277/7206	8.53530426664e-08
ko04060	Cytokine-cytokine receptor interaction	7/1145	191/7206	1.0368464601e-07
ko04740	Olfactory transduction	32/1145	80/7206	1.66974964825e-07
ko05030	Cocaine addiction	30/1145	73/7206	2.00152865507e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1145	74/7206	2.86229074904e-07
ko04966	Collecting duct acid secretion	15/1145	26/7206	1.29432107687e-06
ko05322	Systemic lupus erythematosus	5/1145	151/7206	1.35486465882e-06
ko04022	cGMP-PKG signaling pathway	62/1145	216/7206	1.59102404639e-06
ko04360	Axon guidance	65/1145	233/7206	2.47846279705e-06
ko05164	Influenza A	7/1145	167/7206	2.83245714133e-06
ko03013	RNA transport	7/1145	166/7206	2.84080945356e-06
ko04540	Gap junction	41/1145	128/7206	4.1530349254e-06
ko04972	Pancreatic secretion	37/1145	111/7206	4.7383250487e-06
ko04514	Cell adhesion molecules (CAMs)	41/1145	130/7206	8.11899230154e-06
ko04120	Ubiquitin mediated proteolysis	5/1145	138/7206	8.91996727951e-06
ko04010	MAPK signaling pathway	81/1145	321/7206	1.03956289153e-05
ko04072	Phospholipase D signaling pathway	54/1145	197/7206	2.77497670751e-05
ko04621	NOD-like receptor signaling pathway	8/1145	157/7206	3.69087512587e-05
ko04070	Phosphatidylinositol signaling system	35/1145	112/7206	3.93711205669e-05
ko04110	Cell cycle	7/1145	145/7206	4.82349474557e-05
ko04612	Antigen processing and presentation	1/1145	77/7206	5.12899010691e-05
ko04730	Long-term depression	27/1145	78/7206	5.60088157285e-05
ko04141	Protein processing in endoplasmic reticulum	11/1145	184/7206	5.62224958982e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1145	79/7206	6.34584525239e-05
ko05110	Vibrio cholerae infection	23/1145	63/7206	6.93187017551e-05
ko05169	Epstein-Barr virus infection	14/1145	206/7206	9.79794645457e-05
ko04745	Phototransduction - fly	16/1145	38/7206	0.000101876864609
ko05414	Dilated cardiomyopathy	34/1145	112/7206	0.000116175195756
ko04924	Renin secretion	28/1145	86/7206	0.000137414763463
ko04750	Inflammatory mediator regulation of TRP channels	36/1145	122/7206	0.000137663897231
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1145	59/7206	0.000200583851666
ko04014	Ras signaling pathway	68/1145	279/7206	0.000214481186997
ko04260	Cardiac muscle contraction	30/1145	98/7206	0.000228654906638
ko04610	Complement and coagulation cascades	2/1145	79/7206	0.000267611758589
ko03008	Ribosome biogenesis in eukaryotes	2/1145	79/7206	0.000267611758589
ko04976	Bile secretion	26/1145	80/7206	0.000282425562819
ko05162	Measles	6/1145	120/7206	0.000355799974084
ko04371	Apelin signaling pathway	46/1145	177/7206	0.000520928614868
ko04915	Estrogen signaling pathway	36/1145	131/7206	0.000636877594617
ko05161	Hepatitis B	13/1145	173/7206	0.00145987870058
ko05205	Proteoglycans in cancer	25/1145	271/7206	0.00163853929325
ko04146	Peroxisome	4/1145	89/7206	0.00182609867301
ko04064	NF-kappa B signaling pathway	5/1145	96/7206	0.00185882231354
ko05140	Leishmaniasis	3/1145	75/7206	0.00222600841525
ko04330	Notch signaling pathway	2/1145	62/7206	0.00271115216929
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1145	14/7206	0.00307444347624
ko00310	Lysine degradation	3/1145	73/7206	0.0032465630924
ko04964	Proximal tubule bicarbonate reclamation	11/1145	29/7206	0.00336822271324
ko00240	Pyrimidine metabolism	7/1145	110/7206	0.00361564769305
ko04912	GnRH signaling pathway	32/1145	122/7206	0.00367714556294
ko04626	Plant-pathogen interaction	8/1145	18/7206	0.00389496242951
ko03022	Basal transcription factors	1/1145	44/7206	0.00679291621033
ko05144	Malaria	1/1145	45/7206	0.00679662292702
ko00071	Fatty acid degradation	1/1145	45/7206	0.00679662292702
ko05166	HTLV-I infection	30/1145	292/7206	0.00680490468919
ko03420	Nucleotide excision repair	1/1145	46/7206	0.00703491137353
ko04657	IL-17 signaling pathway	5/1145	87/7206	0.00719493809225
ko04015	Rap1 signaling pathway	61/1145	278/7206	0.00719912163253
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1145	100/7206	0.00839659259102
ko00480	Glutathione metabolism	2/1145	55/7206	0.00852689836176
ko05321	Inflammatory bowel disease (IBD)	2/1145	56/7206	0.00880764498813
ko04350	TGF-beta signaling pathway	7/1145	103/7206	0.00924162330258
ko04115	p53 signaling pathway	4/1145	74/7206	0.00982612121309
ko04923	Regulation of lipolysis in adipocytes	21/1145	77/7206	0.0110337152308
ko00590	Arachidonic acid metabolism	2/1145	52/7206	0.0123381378377
ko04932	Non-alcoholic fatty liver disease (NAFLD)	17/1145	182/7206	0.0133229281083
ko04622	RIG-I-like receptor signaling pathway	3/1145	62/7206	0.0134800569285
ko04114	Oocyte meiosis	33/1145	139/7206	0.0136904891712
ko04214	Apoptosis - fly	4/1145	72/7206	0.0139204010824
ko04922	Glucagon signaling pathway	31/1145	128/7206	0.0140231148677
ko04062	Chemokine signaling pathway	45/1145	201/7206	0.0140957395633
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1145	40/7206	0.0152552638853
ko04630	Jak-STAT signaling pathway	11/1145	132/7206	0.0156176122327
ko00140	Steroid hormone biosynthesis	1/1145	41/7206	0.0158608191353
ko05231	Choline metabolism in cancer	32/1145	134/7206	0.0163024595011
ko04217	Necroptosis	17/1145	178/7206	0.0168016624559
ko04973	Carbohydrate digestion and absorption	13/1145	42/7206	0.0169675907367
ko04918	Thyroid hormone synthesis	22/1145	86/7206	0.0174358062549
ko05133	Pertussis	6/1145	87/7206	0.0177170320888
ko00562	Inositol phosphate metabolism	23/1145	89/7206	0.0183217893091
ko04916	Melanogenesis	33/1145	142/7206	0.0199861976195
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1145	92/7206	0.0211489352723
ko00982	Drug metabolism - cytochrome P450	1/1145	37/7206	0.0225893812216
ko03410	Base excision repair	1/1145	38/7206	0.023190736686
ko03018	RNA degradation	6/1145	84/7206	0.0239694110604
ko05215	Prostate cancer	9/1145	111/7206	0.0250786932896
ko04270	Vascular smooth muscle contraction	35/1145	154/7206	0.0251774879153
ko01524	Platinum drug resistance	5/1145	76/7206	0.0257982423503
ko05145	Toxoplasmosis	11/1145	126/7206	0.0262193879115
ko05418	Fluid shear stress and atherosclerosis	17/1145	173/7206	0.0266524775606
ko00260	Glycine, serine and threonine metabolism	2/1145	48/7206	0.0267048254657
ko04210	Apoptosis	18/1145	180/7206	0.0295703586479
ko05034	Alcoholism	50/1145	238/7206	0.0306000936949
ko05131	Shigellosis	6/1145	82/7206	0.0324072671368
ko05016	Huntington's disease	23/1145	215/7206	0.0366738944974
ko05206	MicroRNAs in cancer	18/1145	177/7206	0.0367597447419
ko04213	Longevity regulating pathway - multiple species	21/1145	86/7206	0.03688966767
ko05222	Small cell lung cancer	7/1145	89/7206	0.0398131089324
ko04668	TNF signaling pathway	11/1145	120/7206	0.0433230282138
ko00230	Purine metabolism	41/1145	194/7206	0.0465042579901
ko04658	Th1 and Th2 cell differentiation	8/1145	96/7206	0.0476216469876
ko04510	Focal adhesion	27/1145	240/7206	0.0478337315415