ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 182/1099 423/7206 6.02667442607e-46 ko04724 Glutamatergic synapse 81/1099 152/7206 2.78247645891e-28 ko05033 Nicotine addiction 44/1099 56/7206 4.78402801603e-26 ko05032 Morphine addiction 63/1099 110/7206 1.65419209842e-24 ko04727 GABAergic synapse 59/1099 110/7206 4.67510782123e-21 ko04713 Circadian entrainment 67/1099 136/7206 4.67964227126e-21 ko04728 Dopaminergic synapse 80/1099 185/7206 2.07036519191e-20 ko04721 Synaptic vesicle cycle 48/1099 80/7206 3.93270223653e-20 ko04725 Cholinergic synapse 71/1099 160/7206 5.43921134068e-19 ko04024 cAMP signaling pathway 98/1099 279/7206 4.62777230939e-17 ko04911 Insulin secretion 56/1099 117/7206 4.69881082666e-17 ko04723 Retrograde endocannabinoid signaling 72/1099 175/7206 5.00501200076e-17 ko04020 Calcium signaling pathway 92/1099 265/7206 1.00067583753e-15 ko04921 Oxytocin signaling pathway 76/1099 209/7206 2.13993583287e-14 ko04742 Taste transduction 35/1099 61/7206 3.47265117987e-14 ko04726 Serotonergic synapse 54/1099 137/7206 3.55933163198e-12 ko04261 Adrenergic signaling in cardiomyocytes 69/1099 205/7206 3.33209110354e-11 ko04970 Salivary secretion 41/1099 95/7206 5.13073080844e-11 ko05031 Amphetamine addiction 39/1099 91/7206 1.96804649859e-10 ko03040 Spliceosome 1/1099 145/7206 1.35131962101e-09 ko04971 Gastric acid secretion 39/1099 98/7206 2.68312327444e-09 ko04720 Long-term potentiation 39/1099 99/7206 3.78884067836e-09 ko04925 Aldosterone synthesis and secretion 38/1099 105/7206 1.13651904921e-07 ko04744 Phototransduction 19/1099 36/7206 1.68034008803e-07 ko05168 Herpes simplex infection 6/1099 182/7206 1.91153005674e-07 ko04740 Olfactory transduction 31/1099 80/7206 2.35596974146e-07 ko05203 Viral carcinogenesis 15/1099 277/7206 3.49982331045e-07 ko03013 RNA transport 5/1099 166/7206 4.85017564303e-07 ko05322 Systemic lupus erythematosus 4/1099 151/7206 4.92479785137e-07 ko04120 Ubiquitin mediated proteolysis 3/1099 138/7206 4.95938531351e-07 ko04360 Axon guidance 65/1099 233/7206 6.05360016826e-07 ko04972 Pancreatic secretion 38/1099 111/7206 6.57727070676e-07 ko04966 Collecting duct acid secretion 15/1099 26/7206 7.5243633091e-07 ko04022 cGMP-PKG signaling pathway 60/1099 216/7206 1.730813059e-06 ko05164 Influenza A 6/1099 167/7206 1.8024080397e-06 ko05030 Cocaine addiction 27/1099 73/7206 4.04288615886e-06 ko04924 Renin secretion 30/1099 86/7206 5.43017874382e-06 ko04514 Cell adhesion molecules (CAMs) 40/1099 130/7206 6.03154984926e-06 ko04010 MAPK signaling pathway 79/1099 321/7206 7.32389102552e-06 ko05110 Vibrio cholerae infection 24/1099 63/7206 7.6483089972e-06 ko04621 NOD-like receptor signaling pathway 6/1099 157/7206 8.07046096351e-06 ko04976 Bile secretion 28/1099 80/7206 1.09019715269e-05 ko04745 Phototransduction - fly 17/1099 38/7206 1.37336511441e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 26/1099 74/7206 2.22438346933e-05 ko04540 Gap junction 38/1099 128/7206 2.92902477634e-05 ko03008 Ribosome biogenesis in eukaryotes 1/1099 79/7206 5.18358997266e-05 ko04750 Inflammatory mediator regulation of TRP channels 36/1099 122/7206 5.81999729114e-05 ko04060 Cytokine-cytokine receptor interaction 11/1099 191/7206 5.91514103326e-05 ko04612 Antigen processing and presentation 1/1099 77/7206 8.0163094957e-05 ko04730 Long-term depression 26/1099 78/7206 8.55370827263e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 26/1099 79/7206 9.45645794791e-05 ko04141 Protein processing in endoplasmic reticulum 11/1099 184/7206 0.000155397884761 ko05169 Epstein-Barr virus infection 14/1099 206/7206 0.000250918453677 ko05414 Dilated cardiomyopathy 32/1099 112/7206 0.000276607026616 ko04070 Phosphatidylinositol signaling system 32/1099 112/7206 0.000276607026616 ko04260 Cardiac muscle contraction 29/1099 98/7206 0.000301997582021 ko05166 HTLV-I infection 24/1099 292/7206 0.000332168219211 ko04110 Cell cycle 8/1099 145/7206 0.000400752264172 ko04964 Proximal tubule bicarbonate reclamation 12/1099 29/7206 0.00062028132439 ko05162 Measles 6/1099 120/7206 0.000740810331175 ko05161 Hepatitis B 12/1099 173/7206 0.00121130428575 ko04072 Phospholipase D signaling pathway 47/1099 197/7206 0.00122511070147 ko04014 Ras signaling pathway 62/1099 279/7206 0.00160162278749 ko05215 Prostate cancer 6/1099 111/7206 0.00198717940068 ko04630 Jak-STAT signaling pathway 8/1099 132/7206 0.00200553587421 ko04961 Endocrine and other factor-regulated calcium reabsorption 18/1099 59/7206 0.00287735645761 ko04626 Plant-pathogen interaction 8/1099 18/7206 0.00298924063513 ko05140 Leishmaniasis 3/1099 75/7206 0.00330823447003 ko04064 NF-kappa B signaling pathway 5/1099 96/7206 0.0038102093001 ko04330 Notch signaling pathway 2/1099 62/7206 0.00409995570784 ko05205 Proteoglycans in cancer 25/1099 271/7206 0.00430191704529 ko05410 Hypertrophic cardiomyopathy (HCM) 26/1099 100/7206 0.00469622161964 ko04214 Apoptosis - fly 3/1099 72/7206 0.00474269948073 ko00310 Lysine degradation 3/1099 73/7206 0.00478343113423 ko00330 Arginine and proline metabolism 2/1099 61/7206 0.0062093409347 ko04916 Melanogenesis 34/1099 142/7206 0.00626872979323 ko04932 Non-alcoholic fatty liver disease (NAFLD) 15/1099 182/7206 0.00634088850166 ko04270 Vascular smooth muscle contraction 36/1099 154/7206 0.00644901067013 ko04915 Estrogen signaling pathway 32/1099 131/7206 0.00645094420267 ko03420 Nucleotide excision repair 1/1099 46/7206 0.00697389489508 ko04610 Complement and coagulation cascades 4/1099 79/7206 0.00717771014194 ko04146 Peroxisome 5/1099 89/7206 0.00727432976058 ko05219 Bladder cancer 1/1099 48/7206 0.0072774563012 ko04371 Apelin signaling pathway 40/1099 177/7206 0.00800669298419 ko04217 Necroptosis 15/1099 178/7206 0.00813668662027 ko05321 Inflammatory bowel disease (IBD) 2/1099 56/7206 0.00873063606287 ko04658 Th1 and Th2 cell differentiation 6/1099 96/7206 0.00980151576773 ko04657 IL-17 signaling pathway 5/1099 87/7206 0.0100940026988 ko04710 Circadian rhythm 13/1099 43/7206 0.0103254600518 ko03022 Basal transcription factors 1/1099 44/7206 0.0104201847568 ko00071 Fatty acid degradation 1/1099 45/7206 0.010705504439 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/1099 14/7206 0.0124104597155 ko00280 Valine, leucine and isoleucine degradation 2/1099 54/7206 0.0126374162876 ko04115 p53 signaling pathway 4/1099 74/7206 0.0140570139209 ko05220 Chronic myeloid leukemia 5/1099 85/7206 0.0140975693075 ko04912 GnRH signaling pathway 29/1099 122/7206 0.0149615504781 ko04923 Regulation of lipolysis in adipocytes 20/1099 77/7206 0.0153928423552 ko04015 Rap1 signaling pathway 57/1099 278/7206 0.0168929545254 ko05145 Toxoplasmosis 10/1099 126/7206 0.0174940418551 ko04622 RIG-I-like receptor signaling pathway 3/1099 62/7206 0.0196241268577 ko05016 Huntington's disease 21/1099 215/7206 0.0207621093852 ko03410 Base excision repair 1/1099 38/7206 0.0230385563361 ko05133 Pertussis 6/1099 87/7206 0.0245062918647 ko05222 Small cell lung cancer 6/1099 89/7206 0.0247928665433 ko00260 Glycine, serine and threonine metabolism 2/1099 48/7206 0.0263549594004 ko00380 Tryptophan metabolism 2/1099 50/7206 0.027257684044 ko05120 Epithelial cell signaling in Helicobacter pylori infection 22/1099 92/7206 0.0274597004562 ko04140 Autophagy - animal 15/1099 164/7206 0.0274796154397 ko04218 Cellular senescence 17/1099 177/7206 0.0339066063761 ko01524 Platinum drug resistance 5/1099 76/7206 0.0356086667314 ko04930 Type II diabetes mellitus 14/1099 54/7206 0.0359154726915 ko00620 Pyruvate metabolism 2/1099 46/7206 0.0379888522819 ko04142 Lysosome 14/1099 151/7206 0.039039172332 ko00240 Pyrimidine metabolism 9/1099 110/7206 0.043598862425 ko04978 Mineral absorption 11/1099 40/7206 0.0437534698183 ko05131 Shigellosis 6/1099 82/7206 0.0440468108651 ko05212 Pancreatic cancer 6/1099 83/7206 0.0444137049805 ko03018 RNA degradation 6/1099 84/7206 0.0452471658719 ko04922 Glucagon signaling pathway 28/1099 128/7206 0.0460026805771 ko04210 Apoptosis 18/1099 180/7206 0.0461129493482 ko04918 Thyroid hormone synthesis 20/1099 86/7206 0.0483134556716 ko04620 Toll-like receptor signaling pathway 8/1099 100/7206 0.0483905106259 ko04960 Aldosterone-regulated sodium reabsorption 11/1099 41/7206 0.0484002166493