ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	214/1268	423/7206	3.49933855148e-58
ko04724	Glutamatergic synapse	93/1268	152/7206	8.02599617299e-34
ko05033	Nicotine addiction	50/1268	56/7206	9.03183275709e-32
ko05032	Morphine addiction	72/1268	110/7206	4.35894789309e-29
ko04713	Circadian entrainment	79/1268	136/7206	1.07295782459e-26
ko04727	GABAergic synapse	69/1268	110/7206	2.95596836714e-26
ko04728	Dopaminergic synapse	89/1268	185/7206	4.02734746208e-22
ko04721	Synaptic vesicle cycle	52/1268	80/7206	4.21865001216e-21
ko04725	Cholinergic synapse	79/1268	160/7206	1.24321198836e-20
ko04020	Calcium signaling pathway	107/1268	265/7206	5.07584798263e-19
ko04723	Retrograde endocannabinoid signaling	80/1268	175/7206	2.75038847017e-18
ko04024	cAMP signaling pathway	107/1268	279/7206	4.98575062167e-17
ko04911	Insulin secretion	59/1268	117/7206	3.02356976221e-16
ko04726	Serotonergic synapse	65/1268	137/7206	4.55997114612e-16
ko04921	Oxytocin signaling pathway	83/1268	209/7206	1.8095437689e-14
ko04742	Taste transduction	37/1268	61/7206	5.72931059305e-14
ko04744	Phototransduction	27/1268	36/7206	6.13816671663e-14
ko05031	Amphetamine addiction	45/1268	91/7206	2.6232375012e-12
ko04720	Long-term potentiation	46/1268	99/7206	2.40590510814e-11
ko03040	Spliceosome	1/1268	145/7206	2.59162729937e-11
ko04261	Adrenergic signaling in cardiomyocytes	75/1268	205/7206	4.32138015261e-11
ko03010	Ribosome	1/1268	129/7206	5.61010571702e-10
ko04970	Salivary secretion	42/1268	95/7206	1.21982967375e-09
ko05203	Viral carcinogenesis	17/1268	277/7206	1.81967124046e-08
ko04925	Aldosterone synthesis and secretion	42/1268	105/7206	7.44798288972e-08
ko05322	Systemic lupus erythematosus	5/1268	151/7206	1.05857082219e-07
ko05030	Cocaine addiction	32/1268	73/7206	1.47526975706e-07
ko03013	RNA transport	7/1268	166/7206	2.51098520575e-07
ko04360	Axon guidance	73/1268	233/7206	2.60580527346e-07
ko04070	Phosphatidylinositol signaling system	42/1268	112/7206	4.74589316215e-07
ko05168	Herpes simplex infection	9/1268	182/7206	5.1072168487e-07
ko04971	Gastric acid secretion	38/1268	98/7206	6.10905864111e-07
ko04740	Olfactory transduction	33/1268	80/7206	7.0445845662e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1268	74/7206	1.33986249938e-06
ko04060	Cytokine-cytokine receptor interaction	11/1268	191/7206	1.68681414403e-06
ko04022	cGMP-PKG signaling pathway	66/1268	216/7206	2.72537049421e-06
ko04010	MAPK signaling pathway	88/1268	321/7206	8.25391871323e-06
ko05164	Influenza A	10/1268	167/7206	1.24474264084e-05
ko04972	Pancreatic secretion	38/1268	111/7206	2.24734086978e-05
ko04966	Collecting duct acid secretion	14/1268	26/7206	2.97759671922e-05
ko04072	Phospholipase D signaling pathway	58/1268	197/7206	3.6898232545e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	29/1268	79/7206	4.13295068865e-05
ko04621	NOD-like receptor signaling pathway	10/1268	157/7206	4.7682487021e-05
ko04141	Protein processing in endoplasmic reticulum	13/1268	184/7206	4.768887342e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1268	79/7206	7.14230892088e-05
ko04745	Phototransduction - fly	17/1268	38/7206	9.23288568824e-05
ko05110	Vibrio cholerae infection	24/1268	63/7206	9.24655363511e-05
ko04730	Long-term depression	28/1268	78/7206	0.000120847473295
ko04514	Cell adhesion molecules (CAMs)	40/1268	130/7206	0.000256791332383
ko04924	Renin secretion	29/1268	86/7206	0.000280712796251
ko04014	Ras signaling pathway	73/1268	279/7206	0.00028294491409
ko04610	Complement and coagulation cascades	3/1268	79/7206	0.000304983390827
ko04540	Gap junction	39/1268	128/7206	0.000367213538386
ko05169	Epstein-Barr virus infection	18/1268	206/7206	0.000381170644277
ko05414	Dilated cardiomyopathy	35/1268	112/7206	0.00038305223662
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1268	59/7206	0.000388837456365
ko04612	Antigen processing and presentation	3/1268	77/7206	0.000445265728763
ko04110	Cell cycle	11/1268	145/7206	0.000839420465946
ko04750	Inflammatory mediator regulation of TRP channels	36/1268	122/7206	0.00107538587166
ko04923	Regulation of lipolysis in adipocytes	25/1268	77/7206	0.00135457855253
ko04626	Plant-pathogen interaction	9/1268	18/7206	0.00166486126572
ko04064	NF-kappa B signaling pathway	6/1268	96/7206	0.00173126177834
ko04260	Cardiac muscle contraction	30/1268	98/7206	0.00183082663922
ko05205	Proteoglycans in cancer	29/1268	271/7206	0.00190969234624
ko05162	Measles	9/1268	120/7206	0.00227583207225
ko05161	Hepatitis B	16/1268	173/7206	0.00233389843004
ko04915	Estrogen signaling pathway	37/1268	131/7206	0.00238730911645
ko05144	Malaria	1/1268	45/7206	0.00274000394907
ko00071	Fatty acid degradation	1/1268	45/7206	0.00274000394907
ko04976	Bile secretion	25/1268	80/7206	0.00274009007624
ko03420	Nucleotide excision repair	1/1268	46/7206	0.0028053912302
ko04115	p53 signaling pathway	4/1268	74/7206	0.00320171323495
ko05140	Leishmaniasis	4/1268	75/7206	0.00327100936001
ko00480	Glutathione metabolism	2/1268	55/7206	0.00371575190521
ko03022	Basal transcription factors	1/1268	44/7206	0.00431871395805
ko04371	Apelin signaling pathway	46/1268	177/7206	0.00488205737121
ko00590	Arachidonic acid metabolism	2/1268	52/7206	0.00537218605827
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1268	14/7206	0.00557949603367
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1268	40/7206	0.00625798103277
ko04658	Th1 and Th2 cell differentiation	7/1268	96/7206	0.00637461106927
ko04622	RIG-I-like receptor signaling pathway	3/1268	62/7206	0.0063748040001
ko03320	PPAR signaling pathway	4/1268	69/7206	0.0064499766164
ko05133	Pertussis	6/1268	87/7206	0.00652711593562
ko00562	Inositol phosphate metabolism	26/1268	89/7206	0.00709344982328
ko00240	Pyrimidine metabolism	9/1268	110/7206	0.00755470427462
ko04912	GnRH signaling pathway	33/1268	122/7206	0.00809211919866
ko03018	RNA degradation	6/1268	84/7206	0.00891068227029
ko04120	Ubiquitin mediated proteolysis	13/1268	138/7206	0.009110808192
ko00630	Glyoxylate and dicarboxylate metabolism	1/1268	38/7206	0.00941563213282
ko03410	Base excision repair	1/1268	38/7206	0.00941563213282
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1268	100/7206	0.0111871319403
ko04146	Peroxisome	7/1268	89/7206	0.0115556140735
ko05231	Choline metabolism in cancer	35/1268	134/7206	0.0115988685916
ko05131	Shigellosis	6/1268	82/7206	0.0123160556248
ko05321	Inflammatory bowel disease (IBD)	3/1268	56/7206	0.0125885267016
ko04214	Apoptosis - fly	5/1268	72/7206	0.0126750381179
ko00310	Lysine degradation	5/1268	73/7206	0.0126931249407
ko05145	Toxoplasmosis	12/1268	126/7206	0.013167272509
ko00982	Drug metabolism - cytochrome P450	1/1268	37/7206	0.0147959088659
ko04710	Circadian rhythm	14/1268	43/7206	0.0150023791564
ko04630	Jak-STAT signaling pathway	13/1268	132/7206	0.0153438952285
ko04711	Circadian rhythm - fly	6/1268	13/7206	0.0163671962842
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1268	182/7206	0.0175456472926
ko00330	Arginine and proline metabolism	4/1268	61/7206	0.0180027832871
ko00280	Valine, leucine and isoleucine degradation	3/1268	54/7206	0.018139686064
ko04922	Glucagon signaling pathway	33/1268	128/7206	0.0186701142637
ko00290	Valine, leucine and isoleucine biosynthesis	3/1268	4/7206	0.0188864111904
ko04217	Necroptosis	20/1268	178/7206	0.0218331937856
ko05166	HTLV-I infection	37/1268	292/7206	0.0228226340661
ko04620	Toll-like receptor signaling pathway	9/1268	100/7206	0.0236177002856
ko04270	Vascular smooth muscle contraction	38/1268	154/7206	0.0243015084358
ko04964	Proximal tubule bicarbonate reclamation	10/1268	29/7206	0.0254373009376
ko05016	Huntington's disease	26/1268	215/7206	0.0292048837849
ko04930	Type II diabetes mellitus	16/1268	54/7206	0.0293750770074
ko05132	Salmonella infection	9/1268	98/7206	0.0313656206575
ko04918	Thyroid hormone synthesis	23/1268	86/7206	0.031807566579
ko05215	Prostate cancer	11/1268	111/7206	0.0321120600654
ko05202	Transcriptional misregulation in cancer	22/1268	188/7206	0.0323367448343
ko04916	Melanogenesis	35/1268	142/7206	0.0336671950282
ko05418	Fluid shear stress and atherosclerosis	20/1268	173/7206	0.0337042459245
ko05222	Small cell lung cancer	8/1268	89/7206	0.0344353927242
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1268	15/7206	0.0348351831287
ko05204	Chemical carcinogenesis	3/1268	48/7206	0.0358781360685
ko05219	Bladder cancer	3/1268	48/7206	0.0358781360685
ko04350	TGF-beta signaling pathway	10/1268	103/7206	0.0361284138776
ko04210	Apoptosis	21/1268	180/7206	0.0368096850599
ko04510	Focal adhesion	30/1268	240/7206	0.0380724280267
ko04657	IL-17 signaling pathway	8/1268	87/7206	0.0457967177134
ko04640	Hematopoietic cell lineage	5/1268	64/7206	0.0458169315315
ko05320	Autoimmune thyroid disease	1/1268	29/7206	0.0478823983427
ko04140	Autophagy - animal	19/1268	164/7206	0.0479121261671
ko05340	Primary immunodeficiency	1/1268	30/7206	0.0498180938013