ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	194/1116	423/7206	2.28540236551e-53
ko05033	Nicotine addiction	50/1116	56/7206	1.54371623327e-34
ko04724	Glutamatergic synapse	87/1116	152/7206	5.83406797219e-33
ko05032	Morphine addiction	69/1116	110/7206	9.40749133328e-30
ko04713	Circadian entrainment	74/1116	136/7206	3.06203208442e-26
ko04727	GABAergic synapse	65/1116	110/7206	6.13390276695e-26
ko04728	Dopaminergic synapse	82/1116	185/7206	2.6907722901e-21
ko04723	Retrograde endocannabinoid signaling	78/1116	175/7206	1.74056113243e-20
ko04725	Cholinergic synapse	73/1116	160/7206	5.84271557794e-20
ko04024	cAMP signaling pathway	103/1116	279/7206	3.87959349079e-19
ko04911	Insulin secretion	56/1116	117/7206	9.60602328844e-17
ko04721	Synaptic vesicle cycle	44/1116	80/7206	2.66914991553e-16
ko04020	Calcium signaling pathway	94/1116	265/7206	2.80987817388e-16
ko04726	Serotonergic synapse	60/1116	137/7206	1.41640506165e-15
ko04921	Oxytocin signaling pathway	76/1116	209/7206	6.06823122151e-14
ko05031	Amphetamine addiction	44/1116	91/7206	1.26862815016e-13
ko04742	Taste transduction	34/1116	61/7206	4.10089304586e-13
ko04720	Long-term potentiation	44/1116	99/7206	5.0189345074e-12
ko04744	Phototransduction	24/1116	36/7206	5.54259943695e-12
ko04261	Adrenergic signaling in cardiomyocytes	70/1116	205/7206	2.19960671171e-11
ko03040	Spliceosome	1/1116	145/7206	8.39672919055e-10
ko05030	Cocaine addiction	32/1116	73/7206	6.33266356794e-09
ko03010	Ribosome	1/1116	129/7206	1.10267527584e-08
ko04925	Aldosterone synthesis and secretion	40/1116	105/7206	1.17874121844e-08
ko04970	Salivary secretion	37/1116	95/7206	2.09192508856e-08
ko04360	Axon guidance	68/1116	233/7206	9.11698059286e-08
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1116	74/7206	1.60374796999e-07
ko04070	Phosphatidylinositol signaling system	39/1116	112/7206	4.20232192654e-07
ko05203	Viral carcinogenesis	16/1116	277/7206	6.60982857411e-07
ko04971	Gastric acid secretion	35/1116	98/7206	6.66275308079e-07
ko04740	Olfactory transduction	30/1116	80/7206	1.17832101254e-06
ko04010	MAPK signaling pathway	82/1116	321/7206	1.77018699366e-06
ko05322	Systemic lupus erythematosus	5/1116	151/7206	2.02062365568e-06
ko05168	Herpes simplex infection	8/1116	182/7206	3.42517842659e-06
ko03013	RNA transport	7/1116	166/7206	6.08831409195e-06
ko04022	cGMP-PKG signaling pathway	58/1116	216/7206	1.36012086536e-05
ko04060	Cytokine-cytokine receptor interaction	10/1116	191/7206	1.57565856827e-05
ko05164	Influenza A	8/1116	167/7206	1.92539801391e-05
ko04514	Cell adhesion molecules (CAMs)	39/1116	130/7206	2.2976219985e-05
ko04730	Long-term depression	27/1116	78/7206	2.41939390551e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1116	79/7206	3.05847374713e-05
ko04072	Phospholipase D signaling pathway	53/1116	197/7206	3.35576131298e-05
ko04972	Pancreatic secretion	34/1116	111/7206	5.06684978386e-05
ko04745	Phototransduction - fly	16/1116	38/7206	7.42014882811e-05
ko05169	Epstein-Barr virus infection	14/1116	206/7206	0.000183711083793
ko04621	NOD-like receptor signaling pathway	9/1116	157/7206	0.000207912126961
ko04141	Protein processing in endoplasmic reticulum	12/1116	184/7206	0.000270225298025
ko04110	Cell cycle	8/1116	145/7206	0.000283355692746
ko05414	Dilated cardiomyopathy	32/1116	112/7206	0.000332344126102
ko04260	Cardiac muscle contraction	29/1116	98/7206	0.000350072535601
ko04612	Antigen processing and presentation	2/1116	77/7206	0.00040056008444
ko03008	Ribosome biogenesis in eukaryotes	2/1116	79/7206	0.000420792534017
ko04924	Renin secretion	26/1116	86/7206	0.000460543223347
ko04014	Ras signaling pathway	65/1116	279/7206	0.000499092592232
ko04966	Collecting duct acid secretion	11/1116	26/7206	0.000953929645863
ko04540	Gap junction	34/1116	128/7206	0.00117710800507
ko05110	Vibrio cholerae infection	20/1116	63/7206	0.00120918658352
ko04610	Complement and coagulation cascades	3/1116	79/7206	0.00157566075563
ko05162	Measles	7/1116	120/7206	0.00200046789602
ko04915	Estrogen signaling pathway	34/1116	131/7206	0.00205117331623
ko04750	Inflammatory mediator regulation of TRP channels	32/1116	122/7206	0.00217105388503
ko00590	Arachidonic acid metabolism	1/1116	52/7206	0.00313100901327
ko04626	Plant-pathogen interaction	8/1116	18/7206	0.0033017465426
ko00562	Inositol phosphate metabolism	24/1116	89/7206	0.00469701362561
ko04710	Circadian rhythm	14/1116	43/7206	0.00470758128718
ko00240	Pyrimidine metabolism	7/1116	110/7206	0.00503566948974
ko05231	Choline metabolism in cancer	33/1116	134/7206	0.005244925456
ko05016	Huntington's disease	19/1116	215/7206	0.00527625601264
ko04120	Ubiquitin mediated proteolysis	10/1116	138/7206	0.00584697840197
ko04923	Regulation of lipolysis in adipocytes	21/1116	77/7206	0.00672739330326
ko03420	Nucleotide excision repair	1/1116	46/7206	0.00690660192441
ko04146	Peroxisome	5/1116	89/7206	0.00728438734114
ko05321	Inflammatory bowel disease (IBD)	2/1116	56/7206	0.00862761954987
ko04964	Proximal tubule bicarbonate reclamation	10/1116	29/7206	0.00915762442213
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1116	182/7206	0.00929284097762
ko04973	Carbohydrate digestion and absorption	13/1116	42/7206	0.00959250970319
ko04658	Th1 and Th2 cell differentiation	6/1116	96/7206	0.00982941714876
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1116	59/7206	0.00985584272552
ko05140	Leishmaniasis	4/1116	75/7206	0.0099656345022
ko05205	Proteoglycans in cancer	27/1116	271/7206	0.00996956122609
ko04630	Jak-STAT signaling pathway	10/1116	132/7206	0.0101853398067
ko04657	IL-17 signaling pathway	5/1116	87/7206	0.0102809090432
ko05166	HTLV-I infection	30/1116	292/7206	0.0103644355681
ko05161	Hepatitis B	15/1116	173/7206	0.010374423017
ko03022	Basal transcription factors	1/1116	44/7206	0.0104745729921
ko05144	Malaria	1/1116	45/7206	0.0109834549675
ko00071	Fatty acid degradation	1/1116	45/7206	0.0109834549675
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1116	100/7206	0.0117661712899
ko04976	Bile secretion	21/1116	80/7206	0.0120127379608
ko04350	TGF-beta signaling pathway	7/1116	103/7206	0.0127199554757
ko00480	Glutathione metabolism	2/1116	55/7206	0.0131598081196
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1116	14/7206	0.0133660441778
ko05131	Shigellosis	5/1116	82/7206	0.0137378908912
ko00310	Lysine degradation	4/1116	73/7206	0.0139448164192
ko04015	Rap1 signaling pathway	58/1116	278/7206	0.0140762049942
ko04115	p53 signaling pathway	4/1116	74/7206	0.0141830793976
ko00330	Arginine and proline metabolism	3/1116	61/7206	0.0194405333988
ko04722	Neurotrophin signaling pathway	36/1116	160/7206	0.0195942255231
ko04330	Notch signaling pathway	3/1116	62/7206	0.019993650327
ko04622	RIG-I-like receptor signaling pathway	3/1116	62/7206	0.019993650327
ko04371	Apelin signaling pathway	39/1116	177/7206	0.0200915328212
ko04064	NF-kappa B signaling pathway	7/1116	96/7206	0.0225852560131
ko03410	Base excision repair	1/1116	38/7206	0.0229122960675
ko05133	Pertussis	6/1116	87/7206	0.024383104445
ko00260	Glycine, serine and threonine metabolism	2/1116	48/7206	0.0262278938988
ko04217	Necroptosis	17/1116	178/7206	0.0270408995506
ko03320	PPAR signaling pathway	4/1116	69/7206	0.0277673775524
ko04912	GnRH signaling pathway	28/1116	122/7206	0.0307786276975
ko04270	Vascular smooth muscle contraction	34/1116	154/7206	0.0315110483355
ko03018	RNA degradation	6/1116	84/7206	0.0327597361603
ko05215	Prostate cancer	9/1116	111/7206	0.033195986023
ko04918	Thyroid hormone synthesis	21/1116	86/7206	0.0340399588225
ko04922	Glucagon signaling pathway	29/1116	128/7206	0.0349652366666
ko04071	Sphingolipid signaling pathway	35/1116	162/7206	0.0362603419071
ko04210	Apoptosis	18/1116	180/7206	0.0370447179204
ko00280	Valine, leucine and isoleucine degradation	3/1116	54/7206	0.0382247136413
ko04711	Circadian rhythm - fly	5/1116	13/7206	0.0385287986641
ko05202	Transcriptional misregulation in cancer	19/1116	188/7206	0.0405323982487
ko04659	Th17 cell differentiation	9/1116	106/7206	0.0426092601753
ko04916	Melanogenesis	31/1116	142/7206	0.0453560768414
ko04214	Apoptosis - fly	5/1116	72/7206	0.0478705878909