ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1250	423/7206	7.70666858823e-46
ko04724	Glutamatergic synapse	91/1250	152/7206	1.4702619168e-32
ko05032	Morphine addiction	71/1250	110/7206	1.57546612814e-28
ko05033	Nicotine addiction	47/1250	56/7206	1.27270692343e-27
ko04727	GABAergic synapse	69/1250	110/7206	1.21139739636e-26
ko04713	Circadian entrainment	77/1250	136/7206	1.82558897517e-25
ko04721	Synaptic vesicle cycle	54/1250	80/7206	2.28267417045e-23
ko04728	Dopaminergic synapse	86/1250	185/7206	1.35454392596e-20
ko04725	Cholinergic synapse	78/1250	160/7206	2.39930359181e-20
ko04723	Retrograde endocannabinoid signaling	80/1250	175/7206	1.12159416541e-18
ko04024	cAMP signaling pathway	107/1250	279/7206	1.55023727709e-17
ko04020	Calcium signaling pathway	101/1250	265/7206	2.1836183909e-16
ko04911	Insulin secretion	56/1250	117/7206	1.69636735534e-14
ko04742	Taste transduction	37/1250	61/7206	3.59326600216e-14
ko04744	Phototransduction	27/1250	36/7206	4.26516565704e-14
ko04921	Oxytocin signaling pathway	81/1250	209/7206	1.18964942441e-13
ko04726	Serotonergic synapse	60/1250	137/7206	2.83430863981e-13
ko04261	Adrenergic signaling in cardiomyocytes	76/1250	205/7206	7.34128947121e-12
ko03040	Spliceosome	1/1250	145/7206	4.31263496941e-11
ko04360	Axon guidance	80/1250	233/7206	1.78883381742e-10
ko04970	Salivary secretion	43/1250	95/7206	1.92489502564e-10
ko05031	Amphetamine addiction	41/1250	91/7206	6.08120989935e-10
ko04720	Long-term potentiation	43/1250	99/7206	9.60381894004e-10
ko05203	Viral carcinogenesis	15/1250	277/7206	3.12695394926e-09
ko03013	RNA transport	6/1250	166/7206	6.54938282521e-08
ko04022	cGMP-PKG signaling pathway	69/1250	216/7206	1.20679613273e-07
ko04925	Aldosterone synthesis and secretion	41/1250	105/7206	1.34982450119e-07
ko04971	Gastric acid secretion	38/1250	98/7206	4.90736887646e-07
ko04740	Olfactory transduction	33/1250	80/7206	5.97560281346e-07
ko05168	Herpes simplex infection	9/1250	182/7206	7.52345380481e-07
ko05030	Cocaine addiction	30/1250	73/7206	2.24920116346e-06
ko04060	Cytokine-cytokine receptor interaction	11/1250	191/7206	2.44431127895e-06
ko05322	Systemic lupus erythematosus	7/1250	151/7206	3.44282904754e-06
ko04924	Renin secretion	33/1250	86/7206	3.97761150898e-06
ko04966	Collecting duct acid secretion	15/1250	26/7206	4.07681544594e-06
ko04010	MAPK signaling pathway	88/1250	321/7206	5.03440661366e-06
ko04621	NOD-like receptor signaling pathway	8/1250	157/7206	5.55043734891e-06
ko04070	Phosphatidylinositol signaling system	39/1250	112/7206	6.73840076578e-06
ko04540	Gap junction	43/1250	128/7206	8.37694486009e-06
ko05164	Influenza A	10/1250	167/7206	1.79112217102e-05
ko04141	Protein processing in endoplasmic reticulum	12/1250	184/7206	1.86402194714e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1250	74/7206	3.20471372596e-05
ko04972	Pancreatic secretion	37/1250	111/7206	3.77069035215e-05
ko04514	Cell adhesion molecules (CAMs)	41/1250	130/7206	5.86313342378e-05
ko04730	Long-term depression	28/1250	78/7206	6.77259012444e-05
ko04610	Complement and coagulation cascades	2/1250	79/7206	7.0196177239e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1250	79/7206	7.0196177239e-05
ko05110	Vibrio cholerae infection	24/1250	63/7206	7.50582238121e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1250	79/7206	0.000122196061815
ko05414	Dilated cardiomyopathy	36/1250	112/7206	0.000123106782974
ko04120	Ubiquitin mediated proteolysis	9/1250	138/7206	0.000249439413935
ko04014	Ras signaling pathway	72/1250	279/7206	0.000269869815579
ko04745	Phototransduction - fly	16/1250	38/7206	0.000294427374935
ko04072	Phospholipase D signaling pathway	54/1250	197/7206	0.000372007083808
ko04146	Peroxisome	4/1250	89/7206	0.00037314656708
ko04923	Regulation of lipolysis in adipocytes	26/1250	77/7206	0.000407249235759
ko05169	Epstein-Barr virus infection	18/1250	206/7206	0.000509556825876
ko04064	NF-kappa B signaling pathway	5/1250	96/7206	0.000596679074038
ko04260	Cardiac muscle contraction	31/1250	98/7206	0.000634222863921
ko04612	Antigen processing and presentation	3/1250	77/7206	0.000680964487713
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1250	59/7206	0.000741471101017
ko05205	Proteoglycans in cancer	27/1250	271/7206	0.000749138555882
ko04110	Cell cycle	11/1250	145/7206	0.000835514742205
ko04976	Bile secretion	26/1250	80/7206	0.000888257044905
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1250	14/7206	0.00089535739128
ko04915	Estrogen signaling pathway	38/1250	131/7206	0.000969815598504
ko04750	Inflammatory mediator regulation of TRP channels	36/1250	122/7206	0.000973909759157
ko00240	Pyrimidine metabolism	7/1250	110/7206	0.00130937572677
ko04626	Plant-pathogen interaction	9/1250	18/7206	0.00149812306885
ko05161	Hepatitis B	15/1250	173/7206	0.00151248945127
ko04371	Apelin signaling pathway	47/1250	177/7206	0.00175553528208
ko03420	Nucleotide excision repair	1/1250	46/7206	0.00278739649386
ko05162	Measles	9/1250	120/7206	0.00319613202261
ko05140	Leishmaniasis	4/1250	75/7206	0.00324396660346
ko00480	Glutathione metabolism	2/1250	55/7206	0.00369059732156
ko05321	Inflammatory bowel disease (IBD)	2/1250	56/7206	0.00380135833154
ko03022	Basal transcription factors	1/1250	44/7206	0.00424941097817
ko05144	Malaria	1/1250	45/7206	0.0044879641909
ko00071	Fatty acid degradation	1/1250	45/7206	0.0044879641909
ko00310	Lysine degradation	4/1250	73/7206	0.0046360398781
ko05131	Shigellosis	5/1250	82/7206	0.00479315590249
ko04916	Melanogenesis	38/1250	142/7206	0.00481082244193
ko04630	Jak-STAT signaling pathway	11/1250	132/7206	0.00498233158632
ko00590	Arachidonic acid metabolism	2/1250	52/7206	0.00541963028144
ko00330	Arginine and proline metabolism	3/1250	61/7206	0.00615546590135
ko04622	RIG-I-like receptor signaling pathway	3/1250	62/7206	0.00623274616449
ko04658	Th1 and Th2 cell differentiation	7/1250	96/7206	0.00630309177377
ko00140	Steroid hormone biosynthesis	1/1250	41/7206	0.00632704208545
ko00380	Tryptophan metabolism	2/1250	50/7206	0.00794546332744
ko00630	Glyoxylate and dicarboxylate metabolism	1/1250	38/7206	0.00955109262025
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1250	40/7206	0.0100032491725
ko04964	Proximal tubule bicarbonate reclamation	11/1250	29/7206	0.0106793996644
ko00260	Glycine, serine and threonine metabolism	2/1250	48/7206	0.0116885722887
ko03018	RNA degradation	6/1250	84/7206	0.0127201017207
ko04115	p53 signaling pathway	5/1250	74/7206	0.012814550236
ko04918	Thyroid hormone synthesis	24/1250	86/7206	0.0140555095726
ko00982	Drug metabolism - cytochrome P450	1/1250	37/7206	0.014568518661
ko04912	GnRH signaling pathway	32/1250	122/7206	0.0151200524309
ko04711	Circadian rhythm - fly	6/1250	13/7206	0.015278886988
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1250	100/7206	0.0158019508835
ko05145	Toxoplasmosis	12/1250	126/7206	0.0172542453401
ko04214	Apoptosis - fly	5/1250	72/7206	0.0178353405981
ko04270	Vascular smooth muscle contraction	38/1250	154/7206	0.0179668186916
ko04640	Hematopoietic cell lineage	4/1250	64/7206	0.0186935295542
ko05133	Pertussis	7/1250	87/7206	0.0215366126742
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1250	182/7206	0.0221048060767
ko04620	Toll-like receptor signaling pathway	9/1250	100/7206	0.0235637110884
ko03320	PPAR signaling pathway	5/1250	69/7206	0.0243386458936
ko04210	Apoptosis	20/1250	180/7206	0.0276814010154
ko04015	Rap1 signaling pathway	62/1250	278/7206	0.0291181445652
ko04062	Chemokine signaling pathway	47/1250	201/7206	0.0292089776358
ko01524	Platinum drug resistance	6/1250	76/7206	0.0314672445626
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1250	15/7206	0.0326709933129
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1250	26/7206	0.0329384695426
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1250	92/7206	0.0362791297717
ko05418	Fluid shear stress and atherosclerosis	20/1250	173/7206	0.04191229515
ko05215	Prostate cancer	11/1250	111/7206	0.042120688382
ko04657	IL-17 signaling pathway	8/1250	87/7206	0.045295080061
ko04510	Focal adhesion	30/1250	240/7206	0.045820503509
ko00562	Inositol phosphate metabolism	23/1250	89/7206	0.0469837841066
ko04930	Type II diabetes mellitus	15/1250	54/7206	0.0477558649032
ko05320	Autoimmune thyroid disease	1/1250	29/7206	0.0478934576141
ko05231	Choline metabolism in cancer	32/1250	134/7206	0.0498821778326
ko04142	Lysosome	17/1250	151/7206	0.0499004827665