ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	188/1149	423/7206	5.10403937798e-47
ko04724	Glutamatergic synapse	85/1149	152/7206	3.11148083347e-30
ko05032	Morphine addiction	68/1149	110/7206	5.51977391487e-28
ko05033	Nicotine addiction	46/1149	56/7206	6.73610856741e-28
ko04727	GABAergic synapse	63/1149	110/7206	2.02235110867e-23
ko04713	Circadian entrainment	71/1149	136/7206	5.30760539525e-23
ko04728	Dopaminergic synapse	83/1149	185/7206	4.07610278962e-21
ko04725	Cholinergic synapse	75/1149	160/7206	1.42402946041e-20
ko04723	Retrograde endocannabinoid signaling	76/1149	175/7206	2.10868447733e-18
ko04024	cAMP signaling pathway	102/1149	279/7206	9.53655351941e-18
ko04721	Synaptic vesicle cycle	45/1149	80/7206	1.18718364442e-16
ko04020	Calcium signaling pathway	95/1149	265/7206	6.70575473213e-16
ko04911	Insulin secretion	55/1149	117/7206	1.84666826403e-15
ko04744	Phototransduction	27/1149	36/7206	4.94260545031e-15
ko04726	Serotonergic synapse	59/1149	137/7206	2.40970235001e-14
ko04921	Oxytocin signaling pathway	78/1149	209/7206	2.60149148043e-14
ko04742	Taste transduction	35/1149	61/7206	1.37342388018e-13
ko04261	Adrenergic signaling in cardiomyocytes	71/1149	205/7206	2.36218201192e-11
ko05031	Amphetamine addiction	41/1149	91/7206	4.08907594706e-11
ko04970	Salivary secretion	40/1149	95/7206	8.74552743142e-10
ko04720	Long-term potentiation	41/1149	99/7206	9.85723539629e-10
ko03040	Spliceosome	2/1149	145/7206	6.43912766171e-09
ko03010	Ribosome	1/1149	129/7206	6.66024720366e-09
ko04925	Aldosterone synthesis and secretion	41/1149	105/7206	7.92506181463e-09
ko05322	Systemic lupus erythematosus	4/1149	151/7206	2.1171251744e-07
ko04971	Gastric acid secretion	36/1149	98/7206	4.27196589671e-07
ko05203	Viral carcinogenesis	17/1149	277/7206	6.22476663071e-07
ko04070	Phosphatidylinositol signaling system	39/1149	112/7206	7.14788964339e-07
ko05030	Cocaine addiction	29/1149	73/7206	8.08548857326e-07
ko03013	RNA transport	6/1149	166/7206	8.15434543967e-07
ko04010	MAPK signaling pathway	84/1149	321/7206	1.57761948834e-06
ko05168	Herpes simplex infection	8/1149	182/7206	1.58945329771e-06
ko04022	cGMP-PKG signaling pathway	62/1149	216/7206	1.6610938427e-06
ko04060	Cytokine-cytokine receptor interaction	9/1149	191/7206	1.7604603252e-06
ko04621	NOD-like receptor signaling pathway	6/1149	157/7206	2.38902270654e-06
ko04360	Axon guidance	64/1149	233/7206	6.35128485917e-06
ko04072	Phospholipase D signaling pathway	56/1149	197/7206	6.82033103433e-06
ko04141	Protein processing in endoplasmic reticulum	10/1149	184/7206	1.47341009522e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1149	74/7206	1.51953928756e-05
ko04514	Cell adhesion molecules (CAMs)	40/1149	130/7206	1.76793416884e-05
ko04972	Pancreatic secretion	36/1149	111/7206	1.77808082632e-05
ko04740	Olfactory transduction	28/1149	80/7206	3.56848689278e-05
ko05164	Influenza A	9/1149	167/7206	3.86973699176e-05
ko04014	Ras signaling pathway	70/1149	279/7206	5.62071378646e-05
ko04730	Long-term depression	27/1149	78/7206	5.74065349806e-05
ko04745	Phototransduction - fly	16/1149	38/7206	0.00010633874866
ko04120	Ubiquitin mediated proteolysis	7/1149	138/7206	0.00013734288636
ko04750	Inflammatory mediator regulation of TRP channels	36/1149	122/7206	0.000142903475779
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1149	79/7206	0.000154510477564
ko04110	Cell cycle	8/1149	145/7206	0.000201456455573
ko03008	Ribosome biogenesis in eukaryotes	2/1149	79/7206	0.000269489541031
ko04924	Renin secretion	27/1149	86/7206	0.000295767358565
ko05414	Dilated cardiomyopathy	33/1149	112/7206	0.000349959107536
ko04540	Gap junction	36/1149	128/7206	0.000372180103148
ko04612	Antigen processing and presentation	2/1149	77/7206	0.00041271336742
ko04976	Bile secretion	25/1149	80/7206	0.000567041792801
ko04064	NF-kappa B signaling pathway	4/1149	96/7206	0.000606819015915
ko04915	Estrogen signaling pathway	36/1149	131/7206	0.000659527728818
ko04260	Cardiac muscle contraction	29/1149	98/7206	0.000683825270699
ko04923	Regulation of lipolysis in adipocytes	24/1149	77/7206	0.000789419093089
ko04964	Proximal tubule bicarbonate reclamation	12/1149	29/7206	0.000936441446522
ko04966	Collecting duct acid secretion	11/1149	26/7206	0.00122479786787
ko04930	Type II diabetes mellitus	18/1149	54/7206	0.00129278359037
ko05169	Epstein-Barr virus infection	17/1149	206/7206	0.00136449668658
ko04610	Complement and coagulation cascades	3/1149	79/7206	0.00161833739592
ko00590	Arachidonic acid metabolism	1/1149	52/7206	0.00199489971217
ko05140	Leishmaniasis	3/1149	75/7206	0.00222713045595
ko05205	Proteoglycans in cancer	26/1149	271/7206	0.00294465817067
ko05162	Measles	8/1149	120/7206	0.0035145235591
ko04626	Plant-pathogen interaction	8/1149	18/7206	0.00398307045221
ko05231	Choline metabolism in cancer	34/1149	134/7206	0.00411164804696
ko04973	Carbohydrate digestion and absorption	14/1149	42/7206	0.00479121579951
ko04217	Necroptosis	15/1149	178/7206	0.00483001034219
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1149	100/7206	0.00533736291998
ko05161	Hepatitis B	15/1149	173/7206	0.00613058399051
ko04961	Endocrine and other factor-regulated calcium reabsorption	18/1149	59/7206	0.0062163539602
ko04371	Apelin signaling pathway	42/1149	177/7206	0.00656497367273
ko03022	Basal transcription factors	1/1149	44/7206	0.00676167254138
ko00071	Fatty acid degradation	1/1149	45/7206	0.00680065774471
ko03420	Nucleotide excision repair	1/1149	46/7206	0.00707691921808
ko04657	IL-17 signaling pathway	5/1149	87/7206	0.00723665135963
ko00562	Inositol phosphate metabolism	24/1149	89/7206	0.00793951490214
ko00280	Valine, leucine and isoleucine degradation	2/1149	54/7206	0.00844827982468
ko00480	Glutathione metabolism	2/1149	55/7206	0.00854171906816
ko05321	Inflammatory bowel disease (IBD)	2/1149	56/7206	0.00886799319781
ko04640	Hematopoietic cell lineage	3/1149	64/7206	0.00939573523254
ko04960	Aldosterone-regulated sodium reabsorption	13/1149	41/7206	0.00976771948955
ko00240	Pyrimidine metabolism	8/1149	110/7206	0.0118449156538
ko04015	Rap1 signaling pathway	60/1149	278/7206	0.0119298051108
ko04146	Peroxisome	6/1149	89/7206	0.0130089070713
ko00330	Arginine and proline metabolism	3/1149	61/7206	0.0133598619391
ko04622	RIG-I-like receptor signaling pathway	3/1149	62/7206	0.0135068527971
ko04270	Vascular smooth muscle contraction	36/1149	154/7206	0.0141237147954
ko00965	Betalain biosynthesis	3/1149	4/7206	0.0142494764632
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1149	14/7206	0.0153738004865
ko05166	HTLV-I infection	32/1149	292/7206	0.0176535710104
ko05133	Pertussis	6/1149	87/7206	0.017709381101
ko04710	Circadian rhythm	13/1149	43/7206	0.0188448649658
ko03410	Base excision repair	1/1149	38/7206	0.0232779716741
ko05110	Vibrio cholerae infection	17/1149	63/7206	0.0233235739032
ko03018	RNA degradation	6/1149	84/7206	0.0239381011997
ko04918	Thyroid hormone synthesis	22/1149	86/7206	0.0247563625505
ko04115	p53 signaling pathway	5/1149	74/7206	0.0254325376073
ko00620	Pyruvate metabolism	2/1149	46/7206	0.0257646170441
ko05145	Toxoplasmosis	11/1149	126/7206	0.0262881541152
ko05214	Glioma	20/1149	79/7206	0.0294514085365
ko05131	Shigellosis	6/1149	82/7206	0.0324583483499
ko00860	Porphyrin and chlorophyll metabolism	1/1149	34/7206	0.0334811492284
ko00500	Starch and sucrose metabolism	1/1149	35/7206	0.0340944395881
ko04214	Apoptosis - fly	5/1149	72/7206	0.034655187884
ko00230	Purine metabolism	42/1149	194/7206	0.0361318682264
ko05016	Huntington's disease	23/1149	215/7206	0.036836040096
ko04213	Longevity regulating pathway - multiple species	21/1149	86/7206	0.0374334481503
ko04912	GnRH signaling pathway	28/1149	122/7206	0.0447340702422
ko04666	Fc gamma R-mediated phagocytosis	28/1149	122/7206	0.0447340702422
ko04114	Oocyte meiosis	31/1149	139/7206	0.0460549284648
ko03320	PPAR signaling pathway	5/1149	69/7206	0.0469501694337
ko04113	Meiosis - yeast	5/1149	70/7206	0.0473445055662
ko04658	Th1 and Th2 cell differentiation	8/1149	96/7206	0.0478323393193
ko04510	Focal adhesion	27/1149	240/7206	0.0479578321939
ko04722	Neurotrophin signaling pathway	35/1149	160/7206	0.0484286007185