ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 37/526 80/7206 1.1696091382e-21 ko04080 Neuroactive ligand-receptor interaction 85/526 423/7206 6.98898132464e-19 ko04724 Glutamatergic synapse 46/526 152/7206 1.17509347583e-17 ko04728 Dopaminergic synapse 49/526 185/7206 4.15734513805e-16 ko05033 Nicotine addiction 25/526 56/7206 1.44465135191e-14 ko04727 GABAergic synapse 35/526 110/7206 1.95254417628e-14 ko05032 Morphine addiction 34/526 110/7206 1.21688934698e-13 ko04713 Circadian entrainment 38/526 136/7206 1.54814754907e-13 ko04966 Collecting duct acid secretion 15/526 26/7206 2.67348931417e-11 ko04723 Retrograde endocannabinoid signaling 40/526 175/7206 3.88866532723e-11 ko05031 Amphetamine addiction 26/526 91/7206 6.92581348073e-10 ko04911 Insulin secretion 29/526 117/7206 2.8147854022e-09 ko04726 Serotonergic synapse 31/526 137/7206 8.53028250496e-09 ko04725 Cholinergic synapse 34/526 160/7206 8.93010850519e-09 ko04024 cAMP signaling pathway 48/526 279/7206 1.32354753968e-08 ko04720 Long-term potentiation 25/526 99/7206 2.37660216311e-08 ko05030 Cocaine addiction 21/526 73/7206 2.71939480366e-08 ko04261 Adrenergic signaling in cardiomyocytes 37/526 205/7206 1.84527752337e-07 ko04921 Oxytocin signaling pathway 37/526 209/7206 4.1005359966e-07 ko04744 Phototransduction 13/526 36/7206 6.98102575833e-07 ko05110 Vibrio cholerae infection 17/526 63/7206 1.57545871869e-06 ko05120 Epithelial cell signaling in Helicobacter pylori infection 21/526 92/7206 1.92602115733e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 18/526 74/7206 3.99274366558e-06 ko04970 Salivary secretion 20/526 95/7206 1.24769140249e-05 ko04626 Plant-pathogen interaction 8/526 18/7206 1.73685805229e-05 ko04145 Phagosome 27/526 162/7206 4.2590491666e-05 ko04022 cGMP-PKG signaling pathway 32/526 216/7206 9.42373001487e-05 ko04060 Cytokine-cytokine receptor interaction 2/526 191/7206 0.000103542557229 ko04924 Renin secretion 17/526 86/7206 0.000127759309039 ko04971 Gastric acid secretion 18/526 98/7206 0.000217417350799 ko04745 Phototransduction - fly 10/526 38/7206 0.000287731729245 ko03040 Spliceosome 1/526 145/7206 0.000305756576453 ko04742 Taste transduction 13/526 61/7206 0.000364419808537 ko00190 Oxidative phosphorylation 21/526 127/7206 0.000369674008004 ko05164 Influenza A 2/526 167/7206 0.000456989345314 ko05010 Alzheimer's disease 29/526 202/7206 0.000466807301203 ko05034 Alcoholism 32/526 238/7206 0.000820595810059 ko04925 Aldosterone synthesis and secretion 18/526 105/7206 0.000853682913943 ko04010 MAPK signaling pathway 40/526 321/7206 0.000869704216025 ko04540 Gap junction 20/526 128/7206 0.000957046997638 ko03010 Ribosome 1/526 129/7206 0.000972823861185 ko04020 Calcium signaling pathway 34/526 265/7206 0.00105054861424 ko05168 Herpes simplex infection 3/526 182/7206 0.00122656843719 ko04114 Oocyte meiosis 21/526 139/7206 0.00134971050423 ko05322 Systemic lupus erythematosus 2/526 151/7206 0.00136943419233 ko05166 HTLV-I infection 9/526 292/7206 0.00265972160932 ko05323 Rheumatoid arthritis 15/526 89/7206 0.00291327545831 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/526 59/7206 0.00317278005555 ko03013 RNA transport 3/526 166/7206 0.00351628606905 ko04730 Long-term depression 13/526 78/7206 0.00390737153354 ko04964 Proximal tubule bicarbonate reclamation 7/526 29/7206 0.00402420437425 ko04260 Cardiac muscle contraction 15/526 98/7206 0.00522584652634 ko04740 Olfactory transduction 13/526 80/7206 0.00713218271462 ko04371 Apelin signaling pathway 23/526 177/7206 0.00753028194139 ko04912 GnRH signaling pathway 17/526 122/7206 0.00806904054072 ko04972 Pancreatic secretion 16/526 111/7206 0.00847058576649 ko04962 Vasopressin-regulated water reabsorption 10/526 58/7206 0.00850391455621 ko04016 MAPK signaling pathway - plant 5/526 20/7206 0.012573249804 ko05203 Viral carcinogenesis 10/526 277/7206 0.0129750938876 ko04360 Axon guidance 27/526 233/7206 0.014616281169 ko04630 Jak-STAT signaling pathway 3/526 132/7206 0.0178251688861 ko04621 NOD-like receptor signaling pathway 4/526 157/7206 0.0185255929572 ko04657 IL-17 signaling pathway 1/526 87/7206 0.0203750796181 ko04510 Focal adhesion 9/526 240/7206 0.0309731512482 ko04014 Ras signaling pathway 30/526 279/7206 0.0334716049082 ko04922 Glucagon signaling pathway 16/526 128/7206 0.036805516461 ko04514 Cell adhesion molecules (CAMs) 16/526 130/7206 0.0386485991589 ko04915 Estrogen signaling pathway 16/526 131/7206 0.0397459064844 ko01524 Platinum drug resistance 1/526 76/7206 0.0427440598716 ko04612 Antigen processing and presentation 1/526 77/7206 0.0433551546367 ko04120 Ubiquitin mediated proteolysis 4/526 138/7206 0.0456418983522 ko04064 NF-kappa B signaling pathway 2/526 96/7206 0.046409516757 ko05146 Amoebiasis 2/526 99/7206 0.0479693427087 ko05200 Pathways in cancer 25/526 492/7206 0.0483593604436 ko04668 TNF signaling pathway 3/526 120/7206 0.0484175977858