ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 152/985 423/7206 3.84346346408e-33 ko04724 Glutamatergic synapse 68/985 152/7206 3.81771758954e-21 ko05033 Nicotine addiction 36/985 56/7206 2.19317358257e-18 ko04020 Calcium signaling pathway 86/985 265/7206 1.26298950616e-15 ko04727 GABAergic synapse 47/985 110/7206 4.86705509541e-14 ko05032 Morphine addiction 47/985 110/7206 4.86705509541e-14 ko04713 Circadian entrainment 53/985 136/7206 1.11199733881e-13 ko04725 Cholinergic synapse 55/985 160/7206 1.46131928032e-11 ko04911 Insulin secretion 43/985 117/7206 2.27385727314e-10 ko04024 cAMP signaling pathway 77/985 279/7206 3.70714981722e-10 ko04723 Retrograde endocannabinoid signaling 56/985 175/7206 3.71498868708e-10 ko04726 Serotonergic synapse 47/985 137/7206 4.95125879073e-10 ko04921 Oxytocin signaling pathway 62/985 209/7206 1.00048060623e-09 ko04728 Dopaminergic synapse 56/985 185/7206 2.89216212899e-09 ko04970 Salivary secretion 34/985 95/7206 3.84863320378e-08 ko04721 Synaptic vesicle cycle 30/985 80/7206 7.28733919659e-08 ko04022 cGMP-PKG signaling pathway 58/985 216/7206 1.77134189289e-07 ko03010 Ribosome 1/985 129/7206 1.82393419611e-07 ko03040 Spliceosome 2/985 145/7206 2.4810398141e-07 ko04720 Long-term potentiation 33/985 99/7206 4.18440487989e-07 ko05031 Amphetamine addiction 31/985 91/7206 5.44691587936e-07 ko03013 RNA transport 4/985 166/7206 8.96150278492e-07 ko04925 Aldosterone synthesis and secretion 33/985 105/7206 2.06490510624e-06 ko04742 Taste transduction 23/985 61/7206 2.18691658514e-06 ko05322 Systemic lupus erythematosus 4/985 151/7206 5.9963621467e-06 ko05203 Viral carcinogenesis 15/985 277/7206 1.00230910538e-05 ko04971 Gastric acid secretion 30/985 98/7206 1.0454077484e-05 ko04072 Phospholipase D signaling pathway 49/985 197/7206 1.96850666975e-05 ko04261 Adrenergic signaling in cardiomyocytes 50/985 205/7206 2.89442537284e-05 ko04070 Phosphatidylinositol signaling system 32/985 112/7206 3.57099027043e-05 ko04010 MAPK signaling pathway 70/985 321/7206 4.17606830663e-05 ko04110 Cell cycle 5/985 145/7206 6.86565527722e-05 ko04730 Long-term depression 24/985 78/7206 7.90010220808e-05 ko04120 Ubiquitin mediated proteolysis 5/985 138/7206 0.000135748811484 ko04270 Vascular smooth muscle contraction 38/985 154/7206 0.000198352232174 ko05030 Cocaine addiction 22/985 73/7206 0.00021322516019 ko05130 Pathogenic Escherichia coli infection 1/985 77/7206 0.000312933397309 ko04710 Circadian rhythm 15/985 43/7206 0.000350618542219 ko04972 Pancreatic secretion 29/985 111/7206 0.000404507755808 ko04750 Inflammatory mediator regulation of TRP channels 31/985 122/7206 0.000452355251506 ko04514 Cell adhesion molecules (CAMs) 32/985 130/7206 0.000690150477994 ko05014 Amyotrophic lateral sclerosis (ALS) 21/985 74/7206 0.000886260619274 ko04964 Proximal tubule bicarbonate reclamation 11/985 29/7206 0.000965149879707 ko04924 Renin secretion 23/985 86/7206 0.00125010036556 ko04014 Ras signaling pathway 57/985 279/7206 0.00133159012202 ko04930 Type II diabetes mellitus 16/985 54/7206 0.00205602655844 ko04976 Bile secretion 21/985 80/7206 0.00264934629716 ko04745 Phototransduction - fly 12/985 38/7206 0.00352947980076 ko04711 Circadian rhythm - fly 6/985 13/7206 0.00467549815733 ko04540 Gap junction 29/985 128/7206 0.00583777103904 ko05016 Huntington's disease 16/985 215/7206 0.00617934285659 ko04141 Protein processing in endoplasmic reticulum 13/985 184/7206 0.0063191680825 ko04371 Apelin signaling pathway 37/985 177/7206 0.00743552400504 ko03050 Proteasome 1/985 54/7206 0.00800521027685 ko05169 Epstein-Barr virus infection 16/985 206/7206 0.0099339007536 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 19/985 79/7206 0.0122535370317 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/985 59/7206 0.0129007555805 ko03015 mRNA surveillance pathway 5/985 93/7206 0.0146783970185 ko03420 Nucleotide excision repair 1/985 46/7206 0.0164457166491 ko04260 Cardiac muscle contraction 22/985 98/7206 0.0167759942754 ko05219 Bladder cancer 1/985 48/7206 0.0175381993806 ko04922 Glucagon signaling pathway 27/985 128/7206 0.0187821786991 ko04966 Collecting duct acid secretion 8/985 26/7206 0.0190725747891 ko04111 Cell cycle - yeast 5/985 90/7206 0.0200501240776 ko04960 Aldosterone-regulated sodium reabsorption 11/985 41/7206 0.0211667601299 ko05231 Choline metabolism in cancer 28/985 134/7206 0.0213101988923 ko05414 Dilated cardiomyopathy 24/985 112/7206 0.0251993115072 ko04918 Thyroid hormone synthesis 19/985 86/7206 0.0270923439329 ko04626 Plant-pathogen interaction 6/985 18/7206 0.0276957331213 ko00280 Valine, leucine and isoleucine degradation 2/985 54/7206 0.0276992440593 ko05222 Small cell lung cancer 5/985 89/7206 0.028019284479 ko05168 Herpes simplex infection 15/985 182/7206 0.0286572885576 ko05012 Parkinson's disease 12/985 155/7206 0.0323988363895 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/985 14/7206 0.0326118903568 ko04630 Jak-STAT signaling pathway 10/985 132/7206 0.0400685561801 ko04360 Axon guidance 43/985 233/7206 0.0410305670325 ko00680 Methane metabolism 9/985 34/7206 0.0415215162389 ko00562 Inositol phosphate metabolism 19/985 89/7206 0.042367363955 ko05162 Measles 9/985 120/7206 0.0446370820471 ko00120 Primary bile acid biosynthesis 6/985 20/7206 0.045587090519 ko05205 Proteoglycans in cancer 26/985 271/7206 0.0471629173949 ko04919 Thyroid hormone signaling pathway 28/985 143/7206 0.0479901438