ko pathway ratio_in_study ratio_in_pop p_value ko04260 Cardiac muscle contraction 26/436 98/7206 6.70329836362e-11 ko05410 Hypertrophic cardiomyopathy (HCM) 21/436 100/7206 3.8242063695e-07 ko04950 Maturity onset diabetes of the young 11/436 29/7206 4.49550503314e-07 ko04512 ECM-receptor interaction 18/436 79/7206 7.37776729296e-07 ko04261 Adrenergic signaling in cardiomyocytes 31/436 205/7206 1.68726859308e-06 ko05033 Nicotine addiction 14/436 56/7206 3.9701103862e-06 ko04727 GABAergic synapse 20/436 110/7206 7.65354797383e-06 ko05414 Dilated cardiomyopathy 20/436 112/7206 1.01507715464e-05 ko04721 Synaptic vesicle cycle 16/436 80/7206 1.81576046207e-05 ko04728 Dopaminergic synapse 27/436 185/7206 2.38899683303e-05 ko04080 Neuroactive ligand-receptor interaction 47/436 423/7206 3.49228852307e-05 ko04974 Protein digestion and absorption 17/436 96/7206 5.23558373173e-05 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 15/436 79/7206 6.26481945021e-05 ko04060 Cytokine-cytokine receptor interaction 1/436 191/7206 0.000152838555544 ko04724 Glutamatergic synapse 22/436 152/7206 0.000176979806699 ko04911 Insulin secretion 18/436 117/7206 0.000209543294541 ko04151 PI3K-Akt signaling pathway 42/436 390/7206 0.000262099623693 ko04010 MAPK signaling pathway 36/436 321/7206 0.00027480428171 ko05014 Amyotrophic lateral sclerosis (ALS) 13/436 74/7206 0.00042813262778 ko04723 Retrograde endocannabinoid signaling 23/436 175/7206 0.00052813584083 ko00350 Tyrosine metabolism 8/436 33/7206 0.000610198955256 ko04611 Platelet activation 1/436 163/7206 0.000702003339718 ko04621 NOD-like receptor signaling pathway 1/436 157/7206 0.00103292647139 ko04713 Circadian entrainment 18/436 136/7206 0.00151594166159 ko04142 Lysosome 1/436 151/7206 0.00152013137691 ko04978 Mineral absorption 8/436 40/7206 0.00232814594241 ko04120 Ubiquitin mediated proteolysis 1/436 138/7206 0.00325037627381 ko04510 Focal adhesion 26/436 240/7206 0.00345060374062 ko04725 Cholinergic synapse 19/436 160/7206 0.00398745741854 ko04140 Autophagy - animal 2/436 164/7206 0.00424566050372 ko04921 Oxytocin signaling pathway 23/436 209/7206 0.0046968028202 ko04360 Axon guidance 25/436 233/7206 0.00473821387599 ko04726 Serotonergic synapse 17/436 137/7206 0.00535320498103 ko04964 Proximal tubule bicarbonate reclamation 6/436 29/7206 0.00683823382985 ko05032 Morphine addiction 14/436 110/7206 0.00726515723107 ko04020 Calcium signaling pathway 27/436 265/7206 0.0079266894546 ko00430 Taurine and hypotaurine metabolism 4/436 14/7206 0.00813617848296 ko04976 Bile secretion 11/436 80/7206 0.0083321887122 ko05322 Systemic lupus erythematosus 2/436 151/7206 0.00863028640047 ko05161 Hepatitis B 3/436 173/7206 0.0095211150535 ko04217 Necroptosis 3/436 178/7206 0.00975169754845 ko00240 Pyrimidine metabolism 1/436 110/7206 0.0143807282846 ko05218 Melanoma 11/436 85/7206 0.0177619294066 ko04924 Renin secretion 11/436 86/7206 0.0185881589989 ko04022 cGMP-PKG signaling pathway 22/436 216/7206 0.0189935129071 ko00950 Isoquinoline alkaloid biosynthesis 3/436 10/7206 0.0191791224115 ko03013 RNA transport 3/436 166/7206 0.0192108381115 ko05203 Viral carcinogenesis 8/436 277/7206 0.020306870763 ko04914 Progesterone-mediated oocyte maturation 1/436 104/7206 0.0208948835909 ko05031 Amphetamine addiction 11/436 91/7206 0.0240976555438 ko05169 Epstein-Barr virus infection 5/436 206/7206 0.0248338410452 ko05010 Alzheimer's disease 20/436 202/7206 0.0340982447778 ko00030 Pentose phosphate pathway 5/436 32/7206 0.0412888287967 ko04930 Type II diabetes mellitus 7/436 54/7206 0.0427635833248 ko00010 Glycolysis / Gluconeogenesis 9/436 74/7206 0.0431722989405 ko00562 Inositol phosphate metabolism 1/436 89/7206 0.0433008735322 ko05416 Viral myocarditis 7/436 55/7206 0.0465630774875 ko04668 TNF signaling pathway 2/436 120/7206 0.0495280397516