ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	97/758	145/7206	2.71902214377e-61
ko03030	DNA replication	29/758	38/7206	1.71564450737e-21
ko04110	Cell cycle	57/758	145/7206	3.54721118871e-20
ko03008	Ribosome biogenesis in eukaryotes	39/758	79/7206	2.5691481101e-18
ko04111	Cell cycle - yeast	40/758	90/7206	1.02558339939e-16
ko03013	RNA transport	54/758	166/7206	5.71857859134e-15
ko03015	mRNA surveillance pathway	35/758	93/7206	3.42664246516e-12
ko03410	Base excision repair	21/758	38/7206	1.126474566e-11
ko04144	Endocytosis	5/758	342/7206	2.55504449209e-11
ko04113	Meiosis - yeast	28/758	70/7206	9.56346006296e-11
ko03430	Mismatch repair	15/758	22/7206	1.57690122824e-10
ko00240	Pyrimidine metabolism	34/758	110/7206	3.15758784059e-09
ko05010	Alzheimer's disease	1/758	202/7206	7.02809431675e-09
ko03420	Nucleotide excision repair	19/758	46/7206	5.55837027419e-08
ko05217	Basal cell carcinoma	23/758	68/7206	1.84182789955e-07
ko05322	Systemic lupus erythematosus	38/758	151/7206	2.28213682554e-07
ko04723	Retrograde endocannabinoid signaling	2/758	175/7206	1.1706686082e-06
ko04724	Glutamatergic synapse	1/758	152/7206	1.39368741415e-06
ko04022	cGMP-PKG signaling pathway	5/758	216/7206	4.88916019355e-06
ko04072	Phospholipase D signaling pathway	4/758	197/7206	5.5050754944e-06
ko04024	cAMP signaling pathway	9/758	279/7206	5.96367845851e-06
ko03440	Homologous recombination	15/758	41/7206	8.55716983375e-06
ko03460	Fanconi anemia pathway	17/758	51/7206	9.26508977772e-06
ko04921	Oxytocin signaling pathway	5/758	209/7206	1.00262099391e-05
ko04270	Vascular smooth muscle contraction	2/758	154/7206	1.28159450081e-05
ko03010	Ribosome	1/758	129/7206	1.55994566677e-05
ko03020	RNA polymerase	12/758	29/7206	1.6046084329e-05
ko04932	Non-alcoholic fatty liver disease (NAFLD)	4/758	182/7206	2.37863239315e-05
ko03018	RNA degradation	22/758	84/7206	3.70583369621e-05
ko04725	Cholinergic synapse	3/758	160/7206	3.81800328697e-05
ko04330	Notch signaling pathway	18/758	62/7206	4.28683186148e-05
ko04621	NOD-like receptor signaling pathway	3/758	157/7206	5.61957169506e-05
ko04713	Circadian entrainment	2/758	136/7206	5.70416261437e-05
ko04726	Serotonergic synapse	2/758	137/7206	5.7390626225e-05
ko04261	Adrenergic signaling in cardiomyocytes	6/758	205/7206	6.78059164363e-05
ko04550	Signaling pathways regulating pluripotency of stem cells	34/758	165/7206	9.4956236059e-05
ko04727	GABAergic synapse	1/758	110/7206	0.000114984499027
ko00230	Purine metabolism	38/758	194/7206	0.000122725052528
ko04915	Estrogen signaling pathway	2/758	131/7206	0.000128601789385
ko04611	Platelet activation	4/758	163/7206	0.000143839219104
ko04371	Apelin signaling pathway	5/758	177/7206	0.000167116881949
ko05168	Herpes simplex infection	36/758	182/7206	0.000187990206736
ko04060	Cytokine-cytokine receptor interaction	6/758	191/7206	0.000271689478307
ko04310	Wnt signaling pathway	35/758	181/7206	0.000313115185051
ko04260	Cardiac muscle contraction	1/758	98/7206	0.000374617304975
ko04971	Gastric acid secretion	1/758	98/7206	0.000374617304975
ko05152	Tuberculosis	6/758	187/7206	0.00037824360441
ko00564	Glycerophospholipid metabolism	1/758	99/7206	0.000380712074968
ko05146	Amoebiasis	1/758	99/7206	0.000380712074968
ko04062	Chemokine signaling pathway	7/758	201/7206	0.000392325249391
ko03022	Basal transcription factors	13/758	44/7206	0.000407330014987
ko04350	TGF-beta signaling pathway	23/758	103/7206	0.000471709501214
ko04510	Focal adhesion	10/758	240/7206	0.000538579917615
ko04970	Salivary secretion	1/758	95/7206	0.000562288423999
ko04974	Protein digestion and absorption	1/758	96/7206	0.000578631655157
ko04390	Hippo signaling pathway	35/758	188/7206	0.000660534611967
ko05142	Chagas disease (American trypanosomiasis)	3/758	130/7206	0.000726773958585
ko05034	Alcoholism	42/758	238/7206	0.000763193071343
ko05032	Morphine addiction	2/758	110/7206	0.000812318055703
ko05414	Dilated cardiomyopathy	2/758	112/7206	0.000854667347155
ko04925	Aldosterone synthesis and secretion	2/758	105/7206	0.00117158302689
ko04659	Th17 cell differentiation	2/758	106/7206	0.00117711520473
ko04924	Renin secretion	1/758	86/7206	0.00121643414209
ko05133	Pertussis	1/758	87/7206	0.00122527023194
ko04728	Dopaminergic synapse	7/758	185/7206	0.00139701494251
ko04668	TNF signaling pathway	3/758	120/7206	0.00144523903855
ko04912	GnRH signaling pathway	3/758	122/7206	0.00147657900656
ko05202	Transcriptional misregulation in cancer	34/758	188/7206	0.0015354770294
ko04933	AGE-RAGE signaling pathway in diabetic complications	4/758	135/7206	0.00164136171748
ko04380	Osteoclast differentiation	4/758	134/7206	0.00164360946801
ko04670	Leukocyte transendothelial migration	5/758	151/7206	0.00178982165598
ko05203	Viral carcinogenesis	46/758	277/7206	0.00180548206058
ko04911	Insulin secretion	3/758	117/7206	0.00206711090956
ko04340	Hedgehog signaling pathway	14/758	58/7206	0.00221870900325
ko04650	Natural killer cell mediated cytotoxicity	2/758	97/7206	0.00245499358455
ko05166	HTLV-I infection	47/758	292/7206	0.00246984706519
ko05410	Hypertrophic cardiomyopathy (HCM)	2/758	100/7206	0.00256002775544
ko04730	Long-term depression	1/758	78/7206	0.00265824643179
ko04976	Bile secretion	1/758	80/7206	0.00270906405635
ko04014	Ras signaling pathway	15/758	279/7206	0.0027256919875
ko04530	Tight junction	11/758	228/7206	0.00285802067719
ko04151	PI3K-Akt signaling pathway	24/758	390/7206	0.00286503738161
ko04070	Phosphatidylinositol signaling system	3/758	112/7206	0.00292210859718
ko04540	Gap junction	4/758	128/7206	0.0032476997114
ko04141	Protein processing in endoplasmic reticulum	8/758	184/7206	0.00331413806564
ko04514	Cell adhesion molecules (CAMs)	4/758	130/7206	0.00338316554049
ko05224	Breast cancer	31/758	174/7206	0.00360924197567
ko00010	Glycolysis / Gluconeogenesis	1/758	74/7206	0.00392385971311
ko05134	Legionellosis	1/758	74/7206	0.00392385971311
ko05140	Leishmaniasis	1/758	75/7206	0.00392401149372
ko04923	Regulation of lipolysis in adipocytes	1/758	77/7206	0.0040931837346
ko04972	Pancreatic secretion	3/758	111/7206	0.00430884033874
ko04660	T cell receptor signaling pathway	4/758	124/7206	0.00453215042678
ko04931	Insulin resistance	5/758	137/7206	0.00466399326469
ko05145	Toxoplasmosis	4/758	126/7206	0.00471510159337
ko05120	Epithelial cell signaling in Helicobacter pylori infection	2/758	92/7206	0.00527944590686
ko05030	Cocaine addiction	1/758	73/7206	0.00599263745233
ko04071	Sphingolipid signaling pathway	7/758	162/7206	0.00620973134444
ko05231	Choline metabolism in cancer	5/758	134/7206	0.00643308692137
ko04810	Regulation of actin cytoskeleton	15/758	264/7206	0.00754881875511
ko04662	B cell receptor signaling pathway	2/758	88/7206	0.00756072440651
ko04910	Insulin signaling pathway	8/758	172/7206	0.00793446689771
ko04620	Toll-like receptor signaling pathway	3/758	100/7206	0.0082413173622
ko04010	MAPK signaling pathway	20/758	321/7206	0.00890441252954
ko04630	Jak-STAT signaling pathway	5/758	132/7206	0.00907112313162
ko00514	Other types of O-glycan biosynthesis	8/758	30/7206	0.0103160791997
ko05160	Hepatitis C	7/758	153/7206	0.0111643878502
ko05110	Vibrio cholerae infection	1/758	63/7206	0.0124565420691
ko00561	Glycerolipid metabolism	1/758	63/7206	0.0124565420691
ko04139	Mitophagy - yeast	9/758	37/7206	0.0124869596496
ko04640	Hematopoietic cell lineage	1/758	64/7206	0.0125538461339
ko05169	Epstein-Barr virus infection	33/758	206/7206	0.0148011132513
ko04612	Antigen processing and presentation	15/758	77/7206	0.0149251491978
ko04740	Olfactory transduction	2/758	80/7206	0.0154059397846
ko04138	Autophagy - yeast	2/758	81/7206	0.0158392246704
ko04750	Inflammatory mediator regulation of TRP channels	5/758	122/7206	0.0163811016711
ko04066	HIF-1 signaling pathway	5/758	123/7206	0.0165615748863
ko04961	Endocrine and other factor-regulated calcium reabsorption	1/758	59/7206	0.0182557018778
ko04722	Neurotrophin signaling pathway	8/758	160/7206	0.0184199532159
ko04152	AMPK signaling pathway	8/758	161/7206	0.0185361246004
ko04622	RIG-I-like receptor signaling pathway	1/758	62/7206	0.0192802048745
ko04146	Peroxisome	3/758	89/7206	0.022679457979
ko00562	Inositol phosphate metabolism	3/758	89/7206	0.022679457979
ko05031	Amphetamine addiction	3/758	91/7206	0.0233546940071
ko04114	Oocyte meiosis	23/758	139/7206	0.0249403398741
ko04218	Cellular senescence	28/758	177/7206	0.0251056566111
ko01200	Carbon metabolism	6/758	128/7206	0.02821697124
ko04922	Glucagon signaling pathway	6/758	128/7206	0.02821697124
ko04712	Circadian rhythm - plant	3/758	7/7206	0.0293411193202
ko05132	Salmonella infection	4/758	98/7206	0.0310517390977
ko04142	Lysosome	8/758	151/7206	0.0315826970192
ko04918	Thyroid hormone synthesis	3/758	86/7206	0.0318626539091
ko00590	Arachidonic acid metabolism	1/758	52/7206	0.0391322521931
ko04012	ErbB signaling pathway	5/758	109/7206	0.040067027645
ko04930	Type II diabetes mellitus	1/758	54/7206	0.0407354086198
ko04015	Rap1 signaling pathway	19/758	278/7206	0.0453809213358
ko04120	Ubiquitin mediated proteolysis	22/758	138/7206	0.0481120826649