ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	206/1235	423/7206	2.08827600329e-54
ko04724	Glutamatergic synapse	87/1235	152/7206	1.55029510929e-29
ko05033	Nicotine addiction	47/1235	56/7206	7.2981168143e-28
ko05032	Morphine addiction	67/1235	110/7206	3.8554577188e-25
ko04713	Circadian entrainment	75/1235	136/7206	3.4028414979e-24
ko04727	GABAergic synapse	65/1235	110/7206	2.23724693067e-23
ko04721	Synaptic vesicle cycle	51/1235	80/7206	1.09686190325e-20
ko04728	Dopaminergic synapse	85/1235	185/7206	2.61362549402e-20
ko04020	Calcium signaling pathway	105/1235	265/7206	8.52484928329e-19
ko04725	Cholinergic synapse	75/1235	160/7206	1.14708065778e-18
ko04024	cAMP signaling pathway	108/1235	279/7206	1.91084159608e-18
ko04723	Retrograde endocannabinoid signaling	77/1235	175/7206	3.78666117565e-17
ko04911	Insulin secretion	58/1235	117/7206	4.26723908576e-16
ko04742	Taste transduction	38/1235	61/7206	3.05016199909e-15
ko04744	Phototransduction	27/1235	36/7206	3.13519907248e-14
ko04726	Serotonergic synapse	60/1235	137/7206	1.63159177869e-13
ko04921	Oxytocin signaling pathway	80/1235	209/7206	1.92258226462e-13
ko04970	Salivary secretion	45/1235	95/7206	6.82068996893e-12
ko04261	Adrenergic signaling in cardiomyocytes	75/1235	205/7206	1.1687389719e-11
ko03040	Spliceosome	1/1235	145/7206	7.34622145478e-11
ko04740	Olfactory transduction	38/1235	80/7206	2.71529287314e-10
ko05203	Viral carcinogenesis	13/1235	277/7206	3.02048668192e-10
ko04022	cGMP-PKG signaling pathway	74/1235	216/7206	5.94223791221e-10
ko05031	Amphetamine addiction	40/1235	91/7206	1.67757148742e-09
ko04720	Long-term potentiation	42/1235	99/7206	2.46289397522e-09
ko04971	Gastric acid secretion	41/1235	98/7206	6.2741144203e-09
ko04925	Aldosterone synthesis and secretion	42/1235	105/7206	2.23970944754e-08
ko04060	Cytokine-cytokine receptor interaction	8/1235	191/7206	4.96340444937e-08
ko05322	Systemic lupus erythematosus	5/1235	151/7206	1.63012201611e-07
ko05168	Herpes simplex infection	8/1235	182/7206	2.21900999613e-07
ko03013	RNA transport	7/1235	166/7206	5.76992647305e-07
ko04360	Axon guidance	70/1235	233/7206	8.30790243526e-07
ko04976	Bile secretion	31/1235	80/7206	3.47704681019e-06
ko05030	Cocaine addiction	29/1235	73/7206	4.71309536433e-06
ko04972	Pancreatic secretion	39/1235	111/7206	4.93397645724e-06
ko04924	Renin secretion	32/1235	86/7206	7.80602341147e-06
ko05164	Influenza A	9/1235	167/7206	9.19355535481e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1235	74/7206	1.70118043966e-05
ko04514	Cell adhesion molecules (CAMs)	42/1235	130/7206	1.80914107111e-05
ko04964	Proximal tubule bicarbonate reclamation	15/1235	29/7206	2.09073686307e-05
ko04966	Collecting duct acid secretion	14/1235	26/7206	2.18260157911e-05
ko04621	NOD-like receptor signaling pathway	9/1235	157/7206	2.4704368532e-05
ko04010	MAPK signaling pathway	84/1235	321/7206	2.83594646825e-05
ko04120	Ubiquitin mediated proteolysis	7/1235	138/7206	3.04062268787e-05
ko04070	Phosphatidylinositol signaling system	37/1235	112/7206	3.68358631672e-05
ko04540	Gap junction	41/1235	128/7206	4.13441818336e-05
ko05169	Epstein-Barr virus infection	15/1235	206/7206	4.63705548824e-05
ko04730	Long-term depression	28/1235	78/7206	5.64619670414e-05
ko04745	Phototransduction - fly	17/1235	38/7206	6.54404821303e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	23/1235	59/7206	6.73095659512e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1235	79/7206	7.02470514926e-05
ko04141	Protein processing in endoplasmic reticulum	13/1235	184/7206	9.32805714836e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1235	79/7206	0.000114108472298
ko04110	Cell cycle	9/1235	145/7206	0.000131544103797
ko04072	Phospholipase D signaling pathway	55/1235	197/7206	0.000159281868356
ko05140	Leishmaniasis	2/1235	75/7206	0.000159677569949
ko04064	NF-kappa B signaling pathway	4/1235	96/7206	0.000180722810947
ko04260	Cardiac muscle contraction	32/1235	98/7206	0.000198522192486
ko05205	Proteoglycans in cancer	25/1235	271/7206	0.000204996469978
ko05110	Vibrio cholerae infection	23/1235	63/7206	0.000267729547252
ko04923	Regulation of lipolysis in adipocytes	26/1235	77/7206	0.000355558575205
ko04750	Inflammatory mediator regulation of TRP channels	37/1235	122/7206	0.000360949732635
ko04371	Apelin signaling pathway	49/1235	177/7206	0.000370203500184
ko05414	Dilated cardiomyopathy	34/1235	112/7206	0.000535492498789
ko04146	Peroxisome	4/1235	89/7206	0.000550787730856
ko04612	Antigen processing and presentation	3/1235	77/7206	0.000673899371382
ko05161	Hepatitis B	14/1235	173/7206	0.000707399765175
ko00520	Amino sugar and nucleotide sugar metabolism	1/1235	55/7206	0.000862840163006
ko05166	HTLV-I infection	30/1235	292/7206	0.001093579733
ko04014	Ras signaling pathway	69/1235	279/7206	0.00112332321321
ko05162	Measles	8/1235	120/7206	0.00130864078971
ko04626	Plant-pathogen interaction	9/1235	18/7206	0.00136998446657
ko04610	Complement and coagulation cascades	4/1235	79/7206	0.00232326082143
ko03420	Nucleotide excision repair	1/1235	46/7206	0.00281202663475
ko03018	RNA degradation	5/1235	84/7206	0.00342677963952
ko00480	Glutathione metabolism	2/1235	55/7206	0.00372990676965
ko05321	Inflammatory bowel disease (IBD)	2/1235	56/7206	0.00375406815843
ko03022	Basal transcription factors	1/1235	44/7206	0.00424575375016
ko04640	Hematopoietic cell lineage	3/1235	64/7206	0.004324931261
ko05144	Malaria	1/1235	45/7206	0.00438407243482
ko00071	Fatty acid degradation	1/1235	45/7206	0.00438407243482
ko00240	Pyrimidine metabolism	8/1235	110/7206	0.00458740830784
ko00310	Lysine degradation	4/1235	73/7206	0.00465566429267
ko04915	Estrogen signaling pathway	35/1235	131/7206	0.00487907092203
ko04630	Jak-STAT signaling pathway	11/1235	132/7206	0.00491214440891
ko04974	Protein digestion and absorption	27/1235	96/7206	0.00617362512946
ko04622	RIG-I-like receptor signaling pathway	3/1235	62/7206	0.00621975089561
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1235	100/7206	0.00690660407365
ko00590	Arachidonic acid metabolism	2/1235	52/7206	0.00835332105932
ko05145	Toxoplasmosis	11/1235	126/7206	0.00860583057396
ko04658	Th1 and Th2 cell differentiation	7/1235	96/7206	0.0088642973043
ko04657	IL-17 signaling pathway	6/1235	87/7206	0.00921615620559
ko05133	Pertussis	6/1235	87/7206	0.00921615620559
ko00330	Arginine and proline metabolism	3/1235	61/7206	0.00926509663169
ko00562	Inositol phosphate metabolism	25/1235	89/7206	0.0100267928635
ko04217	Necroptosis	18/1235	178/7206	0.0113985902218
ko00260	Glycine, serine and threonine metabolism	2/1235	48/7206	0.0117110551035
ko05219	Bladder cancer	2/1235	48/7206	0.0117110551035
ko04115	p53 signaling pathway	5/1235	74/7206	0.0128991410252
ko04710	Circadian rhythm	14/1235	43/7206	0.0130001304012
ko05131	Shigellosis	6/1235	82/7206	0.0172491160965
ko00280	Valine, leucine and isoleucine degradation	3/1235	54/7206	0.018170136224
ko04140	Autophagy - animal	17/1235	164/7206	0.0205347190714
ko04918	Thyroid hormone synthesis	23/1235	86/7206	0.0213263035517
ko05215	Prostate cancer	10/1235	111/7206	0.0215770474747
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1235	14/7206	0.0216311485479
ko00500	Starch and sucrose metabolism	1/1235	35/7206	0.021986057516
ko04922	Glucagon signaling pathway	32/1235	128/7206	0.0237632200059
ko04113	Meiosis - yeast	5/1235	70/7206	0.0245576627125
ko04330	Notch signaling pathway	4/1235	62/7206	0.0260195448756
ko04930	Type II diabetes mellitus	16/1235	54/7206	0.0272481490285
ko04210	Apoptosis	20/1235	180/7206	0.0275619642705
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1235	182/7206	0.0277950761417
ko04270	Vascular smooth muscle contraction	37/1235	154/7206	0.0298617246142
ko04620	Toll-like receptor signaling pathway	9/1235	100/7206	0.0314557192716
ko04015	Rap1 signaling pathway	61/1235	278/7206	0.0346016296001
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1235	40/7206	0.0359029484054
ko00380	Tryptophan metabolism	3/1235	50/7206	0.0366105922156
ko04137	Mitophagy - animal	7/1235	82/7206	0.0382175087448
ko04350	TGF-beta signaling pathway	10/1235	103/7206	0.0472963405133
ko05320	Autoimmune thyroid disease	1/1235	29/7206	0.0481126807447