ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 47/522 152/7206 1.40480523101e-18 ko05033 Nicotine addiction 27/522 56/7206 8.80582850013e-17 ko04744 Phototransduction 21/522 36/7206 1.5565960733e-15 ko04080 Neuroactive ligand-receptor interaction 77/522 423/7206 1.39062225859e-14 ko05032 Morphine addiction 35/522 110/7206 1.54722234672e-14 ko04727 GABAergic synapse 34/522 110/7206 9.72695965389e-14 ko04723 Retrograde endocannabinoid signaling 41/522 175/7206 7.34757393225e-12 ko04713 Circadian entrainment 33/522 136/7206 3.30144876557e-10 ko04728 Dopaminergic synapse 38/522 185/7206 2.57341052108e-09 ko04721 Synaptic vesicle cycle 23/522 80/7206 5.13357776003e-09 ko04726 Serotonergic synapse 30/522 137/7206 2.79193585439e-08 ko04024 cAMP signaling pathway 47/522 279/7206 4.04237524969e-08 ko04020 Calcium signaling pathway 45/522 265/7206 4.61717997666e-08 ko04911 Insulin secretion 26/522 117/7206 1.75157909328e-07 ko04725 Cholinergic synapse 31/522 160/7206 3.15466562444e-07 ko05203 Viral carcinogenesis 3/522 277/7206 2.44473463155e-06 ko04742 Taste transduction 16/522 61/7206 4.34708421131e-06 ko04072 Phospholipase D signaling pathway 32/522 197/7206 1.60444546499e-05 ko05205 Proteoglycans in cancer 4/522 271/7206 2.08094460177e-05 ko04720 Long-term potentiation 20/522 99/7206 2.12270909305e-05 ko04514 Cell adhesion molecules (CAMs) 23/522 130/7206 4.93226175666e-05 ko05030 Cocaine addiction 16/522 73/7206 5.00162662749e-05 ko04921 Oxytocin signaling pathway 32/522 209/7206 5.625453495e-05 ko04261 Adrenergic signaling in cardiomyocytes 31/522 205/7206 8.78112316254e-05 ko05164 Influenza A 1/522 167/7206 0.000101810803248 ko04070 Phosphatidylinositol signaling system 20/522 112/7206 0.000132885975076 ko04010 MAPK signaling pathway 42/522 321/7206 0.000149879955842 ko04970 Salivary secretion 17/522 95/7206 0.000407212292809 ko03040 Spliceosome 1/522 145/7206 0.000478987939033 ko05031 Amphetamine addiction 16/522 91/7206 0.000731353182007 ko05169 Epstein-Barr virus infection 4/522 206/7206 0.000966239396754 ko00562 Inositol phosphate metabolism 15/522 89/7206 0.00165681385884 ko05322 Systemic lupus erythematosus 2/522 151/7206 0.00208174167725 ko05162 Measles 1/522 120/7206 0.00210603525215 ko04260 Cardiac muscle contraction 16/522 98/7206 0.00225904743464 ko05161 Hepatitis B 3/522 173/7206 0.00250477436056 ko04060 Cytokine-cytokine receptor interaction 4/522 191/7206 0.00264870072246 ko04110 Cell cycle 2/522 145/7206 0.00295628068175 ko04710 Circadian rhythm 9/522 43/7206 0.00312584322913 ko04730 Long-term depression 13/522 78/7206 0.00365966392182 ko04925 Aldosterone synthesis and secretion 16/522 105/7206 0.00377804732947 ko04022 cGMP-PKG signaling pathway 27/522 216/7206 0.0047443624944 ko04630 Jak-STAT signaling pathway 2/522 132/7206 0.00586202505257 ko04740 Olfactory transduction 13/522 80/7206 0.00693801020133 ko05166 HTLV-I infection 10/522 292/7206 0.00765674644891 ko04972 Pancreatic secretion 16/522 111/7206 0.00814903367642 ko05145 Toxoplasmosis 2/522 126/7206 0.00831669646692 ko03013 RNA transport 4/522 166/7206 0.0096625312691 ko04620 Toll-like receptor signaling pathway 1/522 100/7206 0.00985342612857 ko05014 Amyotrophic lateral sclerosis (ALS) 12/522 74/7206 0.010163898581 ko05168 Herpes simplex infection 5/522 182/7206 0.0132205227984 ko04932 Non-alcoholic fatty liver disease (NAFLD) 5/522 182/7206 0.0132205227984 ko04144 Endocytosis 37/522 342/7206 0.0134221070764 ko04140 Autophagy - animal 4/522 164/7206 0.0135650766415 ko04510 Focal adhesion 8/522 240/7206 0.0153350807526 ko04218 Cellular senescence 5/522 177/7206 0.0179238913432 ko04120 Ubiquitin mediated proteolysis 3/522 138/7206 0.0184723066249 ko05034 Alcoholism 27/522 238/7206 0.0209598767078 ko05215 Prostate cancer 2/522 111/7206 0.0242858700008 ko04810 Regulation of actin cytoskeleton 10/522 264/7206 0.0283856725248 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 11/522 79/7206 0.0287459857292 ko04137 Mitophagy - animal 1/522 82/7206 0.0295393190914 ko04150 mTOR signaling pathway 6/522 184/7206 0.0303233173134 ko04141 Protein processing in endoplasmic reticulum 6/522 184/7206 0.0303233173134 ko04350 TGF-beta signaling pathway 2/522 103/7206 0.0332230580723 ko04966 Collecting duct acid secretion 5/522 26/7206 0.0361701979133 ko05200 Pathways in cancer 24/522 492/7206 0.0377074241376 ko04621 NOD-like receptor signaling pathway 5/522 157/7206 0.0429699603002 ko05130 Pathogenic Escherichia coli infection 1/522 77/7206 0.0430246354752 ko05211 Renal cell carcinoma 2/522 96/7206 0.0463274346339 ko05132 Salmonella infection 2/522 98/7206 0.0469201921935 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 5/522 28/7206 0.0480245387783