ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	197/1241	423/7206	1.04408302415e-47
ko04724	Glutamatergic synapse	91/1241	152/7206	8.13907363014e-33
ko05033	Nicotine addiction	47/1241	56/7206	9.12413459847e-28
ko04727	GABAergic synapse	68/1241	110/7206	6.4307573305e-26
ko05032	Morphine addiction	67/1241	110/7206	5.15861729086e-25
ko04713	Circadian entrainment	75/1241	136/7206	4.65958958222e-24
ko04721	Synaptic vesicle cycle	54/1241	80/7206	1.59200681629e-23
ko04728	Dopaminergic synapse	86/1241	185/7206	8.2519608583e-21
ko04725	Cholinergic synapse	78/1241	160/7206	1.5153851686e-20
ko04723	Retrograde endocannabinoid signaling	79/1241	175/7206	3.01600192387e-18
ko04742	Taste transduction	39/1241	61/7206	4.25401129773e-16
ko04024	cAMP signaling pathway	103/1241	279/7206	1.03662933914e-15
ko04020	Calcium signaling pathway	99/1241	265/7206	1.49134382904e-15
ko04921	Oxytocin signaling pathway	83/1241	209/7206	4.76090539509e-15
ko04911	Insulin secretion	56/1241	117/7206	1.22721840175e-14
ko04744	Phototransduction	27/1241	36/7206	3.5476906016e-14
ko04726	Serotonergic synapse	61/1241	137/7206	5.10683093337e-14
ko04720	Long-term potentiation	46/1241	99/7206	1.10882699555e-11
ko04261	Adrenergic signaling in cardiomyocytes	75/1241	205/7206	1.42129162816e-11
ko03040	Spliceosome	1/1241	145/7206	4.36317362448e-11
ko05031	Amphetamine addiction	42/1241	91/7206	1.1534357716e-10
ko04970	Salivary secretion	43/1241	95/7206	1.51419669046e-10
ko04740	Olfactory transduction	35/1241	80/7206	2.32052200468e-08
ko04360	Axon guidance	73/1241	233/7206	7.79793377911e-08
ko04971	Gastric acid secretion	39/1241	98/7206	9.48471332086e-08
ko04925	Aldosterone synthesis and secretion	41/1241	105/7206	1.24036553909e-07
ko05168	Herpes simplex infection	8/1241	182/7206	2.27755953435e-07
ko05203	Viral carcinogenesis	19/1241	277/7206	3.76077357479e-07
ko03013	RNA transport	7/1241	166/7206	3.81613059967e-07
ko04966	Collecting duct acid secretion	16/1241	26/7206	5.13608390087e-07
ko04060	Cytokine-cytokine receptor interaction	10/1241	191/7206	8.17881444176e-07
ko04022	cGMP-PKG signaling pathway	66/1241	216/7206	9.18967631332e-07
ko04120	Ubiquitin mediated proteolysis	5/1241	138/7206	1.11630384718e-06
ko04540	Gap junction	44/1241	128/7206	2.35426634487e-06
ko05030	Cocaine addiction	29/1241	73/7206	5.03036274395e-06
ko05164	Influenza A	9/1241	167/7206	6.14991608579e-06
ko04260	Cardiac muscle contraction	35/1241	98/7206	9.35813140981e-06
ko04514	Cell adhesion molecules (CAMs)	43/1241	130/7206	9.56373093139e-06
ko04010	MAPK signaling pathway	86/1241	321/7206	1.02717142981e-05
ko04972	Pancreatic secretion	38/1241	111/7206	1.12979643062e-05
ko05322	Systemic lupus erythematosus	8/1241	151/7206	1.62486332671e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1241	74/7206	1.85354669917e-05
ko04924	Renin secretion	31/1241	86/7206	3.42460693412e-05
ko04070	Phosphatidylinositol signaling system	37/1241	112/7206	3.93350217018e-05
ko04730	Long-term depression	28/1241	78/7206	6.06422154453e-05
ko04141	Protein processing in endoplasmic reticulum	13/1241	184/7206	6.67379066809e-05
ko05110	Vibrio cholerae infection	24/1241	63/7206	6.78139129453e-05
ko04745	Phototransduction - fly	17/1241	38/7206	6.97318135466e-05
ko04610	Complement and coagulation cascades	2/1241	79/7206	7.10150550053e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1241	79/7206	7.10150550053e-05
ko04621	NOD-like receptor signaling pathway	10/1241	157/7206	9.72207108795e-05
ko05169	Epstein-Barr virus infection	16/1241	206/7206	0.000107920731433
ko05414	Dilated cardiomyopathy	36/1241	112/7206	0.000114963351037
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1241	79/7206	0.000116802876181
ko04976	Bile secretion	28/1241	80/7206	0.000130139292534
ko04915	Estrogen signaling pathway	40/1241	131/7206	0.000152556740359
ko05140	Leishmaniasis	2/1241	75/7206	0.000159413314596
ko04072	Phospholipase D signaling pathway	55/1241	197/7206	0.00016452189753
ko04064	NF-kappa B signaling pathway	4/1241	96/7206	0.000181339258233
ko05205	Proteoglycans in cancer	25/1241	271/7206	0.000204645899074
ko04371	Apelin signaling pathway	50/1241	177/7206	0.000245668434614
ko04014	Ras signaling pathway	72/1241	279/7206	0.000249915571449
ko04626	Plant-pathogen interaction	10/1241	18/7206	0.000253996499232
ko05162	Measles	7/1241	120/7206	0.000340803436403
ko04110	Cell cycle	10/1241	145/7206	0.00034446443116
ko04750	Inflammatory mediator regulation of TRP channels	37/1241	122/7206	0.000371285202105
ko04964	Proximal tubule bicarbonate reclamation	13/1241	29/7206	0.00048741328659
ko00480	Glutathione metabolism	1/1241	55/7206	0.000536086293556
ko04146	Peroxisome	4/1241	89/7206	0.000555280536356
ko04612	Antigen processing and presentation	3/1241	77/7206	0.000674427021046
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1241	59/7206	0.000701334624206
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1241	14/7206	0.000851513235742
ko00590	Arachidonic acid metabolism	1/1241	52/7206	0.00126903049609
ko00240	Pyrimidine metabolism	7/1241	110/7206	0.00129181664315
ko05161	Hepatitis B	15/1241	173/7206	0.00151735549339
ko04923	Regulation of lipolysis in adipocytes	24/1241	77/7206	0.00222362135719
ko03420	Nucleotide excision repair	1/1241	46/7206	0.00279787377562
ko05321	Inflammatory bowel disease (IBD)	2/1241	56/7206	0.00376602574671
ko03022	Basal transcription factors	1/1241	44/7206	0.00424135515092
ko00071	Fatty acid degradation	1/1241	45/7206	0.0044192436304
ko00310	Lysine degradation	4/1241	73/7206	0.00463714740377
ko04622	RIG-I-like receptor signaling pathway	3/1241	62/7206	0.00621352096214
ko00140	Steroid hormone biosynthesis	1/1241	41/7206	0.00636246287064
ko04214	Apoptosis - fly	4/1241	72/7206	0.00679354359486
ko04912	GnRH signaling pathway	33/1241	122/7206	0.00727498526423
ko05145	Toxoplasmosis	11/1241	126/7206	0.00856269598489
ko04922	Glucagon signaling pathway	34/1241	128/7206	0.00881049788605
ko01524	Platinum drug resistance	5/1241	76/7206	0.00929093033527
ko04657	IL-17 signaling pathway	6/1241	87/7206	0.00929508593066
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1241	40/7206	0.00989554320774
ko03018	RNA degradation	6/1241	84/7206	0.0125636043449
ko04115	p53 signaling pathway	5/1241	74/7206	0.0128414438533
ko04916	Melanogenesis	36/1241	142/7206	0.0131241505901
ko00982	Drug metabolism - cytochrome P450	1/1241	37/7206	0.0145129775998
ko05231	Choline metabolism in cancer	34/1241	134/7206	0.0150315795093
ko00630	Glyoxylate and dicarboxylate metabolism	1/1241	38/7206	0.0152026750856
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1241	100/7206	0.0154121567537
ko05144	Malaria	2/1241	45/7206	0.0170146788715
ko05131	Shigellosis	6/1241	82/7206	0.0173881061424
ko04658	Th1 and Th2 cell differentiation	8/1241	96/7206	0.0197965586108
ko05133	Pertussis	7/1241	87/7206	0.0214071742589
ko05166	HTLV-I infection	36/1241	292/7206	0.021800108218
ko00562	Inositol phosphate metabolism	24/1241	89/7206	0.022551342422
ko05418	Fluid shear stress and atherosclerosis	19/1241	173/7206	0.0250404223912
ko00330	Arginine and proline metabolism	4/1241	61/7206	0.0255448647464
ko04330	Notch signaling pathway	4/1241	62/7206	0.0261959661531
ko04630	Jak-STAT signaling pathway	13/1241	132/7206	0.0261967033645
ko04210	Apoptosis	20/1241	180/7206	0.027505972005
ko04930	Type II diabetes mellitus	16/1241	54/7206	0.0275437031621
ko04015	Rap1 signaling pathway	62/1241	278/7206	0.0283241309091
ko04213	Longevity regulating pathway - multiple species	23/1241	86/7206	0.0296760922836
ko04114	Oocyte meiosis	34/1241	139/7206	0.0303160529936
ko05132	Salmonella infection	9/1241	98/7206	0.031091998179
ko04620	Toll-like receptor signaling pathway	9/1241	100/7206	0.0316406622648
ko05206	MicroRNAs in cancer	20/1241	177/7206	0.0340641624571
ko05120	Epithelial cell signaling in Helicobacter pylori infection	24/1241	92/7206	0.0356486056084
ko00380	Tryptophan metabolism	3/1241	50/7206	0.0366902121495
ko04062	Chemokine signaling pathway	46/1241	201/7206	0.0367134033519
ko04668	TNF signaling pathway	12/1241	120/7206	0.0373098363456
ko04918	Thyroid hormone synthesis	22/1241	86/7206	0.0442308104178
ko04640	Hematopoietic cell lineage	5/1241	64/7206	0.0453791453673
ko05222	Small cell lung cancer	8/1241	89/7206	0.0463693411944
ko04350	TGF-beta signaling pathway	10/1241	103/7206	0.0474568378321
ko05320	Autoimmune thyroid disease	1/1241	29/7206	0.0480019859451