ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 66/401 145/7206 2.84903237584e-45 ko03030 DNA replication 24/401 38/7206 1.87692609207e-21 ko04110 Cell cycle 42/401 145/7206 7.93084267326e-20 ko04111 Cell cycle - yeast 28/401 90/7206 1.89371614082e-14 ko03013 RNA transport 37/401 166/7206 1.37480613812e-13 ko03440 Homologous recombination 18/401 41/7206 1.11554955739e-12 ko03410 Base excision repair 17/401 38/7206 3.30138794749e-12 ko03430 Mismatch repair 12/401 22/7206 2.92214556363e-10 ko03460 Fanconi anemia pathway 17/401 51/7206 8.65207274373e-10 ko00240 Pyrimidine metabolism 24/401 110/7206 4.92133479307e-09 ko03420 Nucleotide excision repair 15/401 46/7206 1.22414652641e-08 ko04113 Meiosis - yeast 18/401 70/7206 2.85590432608e-08 ko04115 p53 signaling pathway 16/401 74/7206 2.14216407688e-06 ko05168 Herpes simplex infection 27/401 182/7206 2.39657200224e-06 ko03008 Ribosome biogenesis in eukaryotes 16/401 79/7206 5.31139558526e-06 ko03015 mRNA surveillance pathway 17/401 93/7206 1.15765554101e-05 ko04218 Cellular senescence 23/401 177/7206 0.000149256037841 ko04120 Ubiquitin mediated proteolysis 19/401 138/7206 0.000209971291966 ko04060 Cytokine-cytokine receptor interaction 1/401 191/7206 0.000331280238764 ko05203 Viral carcinogenesis 30/401 277/7206 0.000409445206703 ko03018 RNA degradation 13/401 84/7206 0.000680625552234 ko04261 Adrenergic signaling in cardiomyocytes 2/401 205/7206 0.00101541705195 ko05222 Small cell lung cancer 13/401 89/7206 0.00118773693825 ko05206 MicroRNAs in cancer 20/401 177/7206 0.00229435106801 ko05166 HTLV-I infection 29/401 292/7206 0.00237880532161 ko00230 Purine metabolism 21/401 194/7206 0.00354240129951 ko03020 RNA polymerase 6/401 29/7206 0.00455194247745 ko04144 Endocytosis 8/401 342/7206 0.00510484536704 ko04723 Retrograde endocannabinoid signaling 2/401 175/7206 0.00644454202251 ko04380 Osteoclast differentiation 1/401 134/7206 0.0069192241131 ko04931 Insulin resistance 1/401 137/7206 0.00710772742754 ko05010 Alzheimer's disease 3/401 202/7206 0.00716283704728 ko04024 cAMP signaling pathway 6/401 279/7206 0.00734307209809 ko05169 Epstein-Barr virus infection 21/401 206/7206 0.00768819873663 ko04145 Phagosome 2/401 162/7206 0.00864245765095 ko04022 cGMP-PKG signaling pathway 4/401 216/7206 0.0100530212819 ko03022 Basal transcription factors 7/401 44/7206 0.0100601249123 ko05142 Chagas disease (American trypanosomiasis) 1/401 130/7206 0.0103434504 ko04514 Cell adhesion molecules (CAMs) 1/401 130/7206 0.0103434504 ko04270 Vascular smooth muscle contraction 2/401 154/7206 0.0122342397043 ko04621 NOD-like receptor signaling pathway 2/401 157/7206 0.012396058753 ko04114 Oocyte meiosis 15/401 139/7206 0.0131663330242 ko04728 Dopaminergic synapse 3/401 185/7206 0.013566298703 ko04912 GnRH signaling pathway 1/401 122/7206 0.0148324434238 ko04750 Inflammatory mediator regulation of TRP channels 1/401 122/7206 0.0148324434238 ko04142 Lysosome 2/401 151/7206 0.0177433942108 ko04724 Glutamatergic synapse 2/401 152/7206 0.0179697626591 ko04070 Phosphatidylinositol signaling system 1/401 112/7206 0.0210444632328 ko04916 Melanogenesis 2/401 142/7206 0.0246049767436 ko05205 Proteoglycans in cancer 7/401 271/7206 0.0293510309602 ko04151 PI3K-Akt signaling pathway 12/401 390/7206 0.0299232577674 ko04925 Aldosterone synthesis and secretion 1/401 105/7206 0.0304046382014 ko04915 Estrogen signaling pathway 2/401 131/7206 0.0341830528997 ko04713 Circadian entrainment 2/401 136/7206 0.034952320998 ko04725 Cholinergic synapse 3/401 160/7206 0.0352465965459 ko05161 Hepatitis B 16/401 173/7206 0.0420648754191 ko04971 Gastric acid secretion 1/401 98/7206 0.0438429069137 ko05146 Amoebiasis 1/401 99/7206 0.0440841885886 ko00564 Glycerophospholipid metabolism 1/401 99/7206 0.0440841885886 ko04620 Toll-like receptor signaling pathway 1/401 100/7206 0.0444512589867 ko04014 Ras signaling pathway 8/401 279/7206 0.0448416205741 ko03450 Non-homologous end-joining 3/401 15/7206 0.0472351049045 ko01200 Carbon metabolism 2/401 128/7206 0.0486060910087 ko04922 Glucagon signaling pathway 2/401 128/7206 0.0486060910087 ko05212 Pancreatic cancer 9/401 83/7206 0.0486326285902 ko05219 Bladder cancer 6/401 48/7206 0.0486435535579