ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 19/171 152/7206 2.35564286934e-09 ko04912 GnRH signaling pathway 14/171 122/7206 9.71272262183e-07 ko04211 Longevity regulating pathway 14/171 123/7206 1.07363843062e-06 ko05032 Morphine addiction 13/171 110/7206 1.71934383602e-06 ko04213 Longevity regulating pathway - multiple species 11/171 86/7206 5.09860296344e-06 ko04914 Progesterone-mediated oocyte maturation 12/171 104/7206 5.6296781149e-06 ko04010 MAPK signaling pathway 22/171 321/7206 6.22096118049e-06 ko04728 Dopaminergic synapse 16/171 185/7206 7.09900586366e-06 ko04727 GABAergic synapse 12/171 110/7206 1.01243368926e-05 ko04022 cGMP-PKG signaling pathway 17/171 216/7206 1.28458731404e-05 ko05231 Choline metabolism in cancer 13/171 134/7206 1.56319752565e-05 ko04072 Phospholipase D signaling pathway 16/171 197/7206 1.57927391794e-05 ko04713 Circadian entrainment 13/171 136/7206 1.83534967753e-05 ko01522 Endocrine resistance 12/171 124/7206 3.43658185493e-05 ko05030 Cocaine addiction 9/171 73/7206 5.09307358214e-05 ko04915 Estrogen signaling pathway 12/171 131/7206 5.92860783404e-05 ko04923 Regulation of lipolysis in adipocytes 9/171 77/7206 7.80260797744e-05 ko04015 Rap1 signaling pathway 18/171 278/7206 9.67008064805e-05 ko04024 cAMP signaling pathway 18/171 279/7206 0.000101256185768 ko04725 Cholinergic synapse 13/171 160/7206 0.000101424505514 ko04913 Ovarian steroidogenesis 8/171 63/7206 0.000108703683243 ko04144 Endocytosis 20/171 342/7206 0.000159483473593 ko04925 Aldosterone synthesis and secretion 10/171 105/7206 0.000179565414378 ko04723 Retrograde endocannabinoid signaling 13/171 175/7206 0.000249490656754 ko04930 Type II diabetes mellitus 7/171 54/7206 0.000259234720865 ko05033 Nicotine addiction 7/171 56/7206 0.000326221531079 ko04261 Adrenergic signaling in cardiomyocytes 14/171 205/7206 0.000345686595195 ko04360 Axon guidance 15/171 233/7206 0.00040107395477 ko04911 Insulin secretion 10/171 117/7206 0.000434727891353 ko04140 Autophagy - animal 12/171 164/7206 0.00049650236694 ko04720 Long-term potentiation 9/171 99/7206 0.000535915713363 ko01521 EGFR tyrosine kinase inhibitor resistance 9/171 106/7206 0.000882414982139 ko04540 Gap junction 10/171 128/7206 0.000883827856984 ko04371 Apelin signaling pathway 12/171 177/7206 0.000979781904257 ko05031 Amphetamine addiction 8/171 91/7206 0.00135888752692 ko04114 Oocyte meiosis 10/171 139/7206 0.00165964821599 ko04970 Salivary secretion 8/171 95/7206 0.00179391895703 ko04910 Insulin signaling pathway 11/171 172/7206 0.00252492806279 ko04742 Taste transduction 6/171 61/7206 0.00308383851829 ko04270 Vascular smooth muscle contraction 10/171 154/7206 0.00352578396633 ko04014 Ras signaling pathway 15/171 279/7206 0.00357855253188 ko05210 Colorectal cancer 7/171 86/7206 0.00417069889894 ko04918 Thyroid hormone synthesis 7/171 86/7206 0.00417069889894 ko04611 Platelet activation 10/171 163/7206 0.00527345587636 ko04020 Calcium signaling pathway 14/171 265/7206 0.00558585688345 ko04320 Dorso-ventral axis formation 4/171 31/7206 0.00584136984747 ko04013 MAPK signaling pathway - fly 8/171 115/7206 0.0058555797617 ko04916 Melanogenesis 9/171 142/7206 0.00649699743243 ko04668 TNF signaling pathway 8/171 120/7206 0.00753056188068 ko04062 Chemokine signaling pathway 11/171 201/7206 0.0081510510048 ko04750 Inflammatory mediator regulation of TRP channels 8/171 122/7206 0.00829317802022 ko00564 Glycerophospholipid metabolism 7/171 99/7206 0.00894665777309 ko04664 Fc epsilon RI signaling pathway 6/171 77/7206 0.00965538113175 ko05166 HTLV-I infection 14/171 292/7206 0.0101513362551 ko04730 Long-term depression 6/171 78/7206 0.010259856138 ko05142 Chagas disease (American trypanosomiasis) 8/171 130/7206 0.0119344743748 ko04150 mTOR signaling pathway 10/171 184/7206 0.0119801213983 ko04152 AMPK signaling pathway 9/171 161/7206 0.0141826169806 ko04012 ErbB signaling pathway 7/171 109/7206 0.0147193851241 ko05218 Melanoma 6/171 85/7206 0.0152640121836 ko05213 Endometrial cancer 5/171 62/7206 0.0154500117497 ko04972 Pancreatic secretion 7/171 111/7206 0.0161341535023 ko05215 Prostate cancer 7/171 111/7206 0.0161341535023 ko04550 Signaling pathways regulating pluripotency of stem cells 9/171 165/7206 0.0164215856314 ko04070 Phosphatidylinositol signaling system 7/171 112/7206 0.0168766195605 ko05414 Dilated cardiomyopathy 7/171 112/7206 0.0168766195605 ko04917 Prolactin signaling pathway 6/171 87/7206 0.0169588960673 ko00515 Mannose type O-glycan biosynthesis 3/171 25/7206 0.0205840368528 ko05224 Breast cancer 9/171 174/7206 0.0223934972721 ko04066 HIF-1 signaling pathway 7/171 123/7206 0.0266988667677 ko04971 Gastric acid secretion 6/171 98/7206 0.0286259461252 ko05014 Amyotrophic lateral sclerosis (ALS) 5/171 74/7206 0.0307095778678 ko05200 Pathways in cancer 19/171 492/7206 0.0310247220774 ko05169 Epstein-Barr virus infection 10/171 206/7206 0.031072329214 ko04620 Toll-like receptor signaling pathway 6/171 100/7206 0.0312016983724 ko04711 Circadian rhythm - fly 2/171 13/7206 0.0367815501122 ko05214 Glioma 5/171 79/7206 0.0391395887694 ko04976 Bile secretion 5/171 80/7206 0.0409789783137 ko04740 Olfactory transduction 5/171 80/7206 0.0409789783137 ko05230 Central carbon metabolism in cancer 5/171 81/7206 0.0428700741122 ko04931 Insulin resistance 7/171 137/7206 0.0440629291132 ko04962 Vasopressin-regulated water reabsorption 4/171 58/7206 0.0482389608398 ko04340 Hedgehog signaling pathway 4/171 58/7206 0.0482389608398