ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko03040	Spliceosome	72/528	145/7206	4.17031579341e-44
ko04110	Cell cycle	57/528	145/7206	3.11736626142e-28
ko04111	Cell cycle - yeast	41/528	90/7206	1.65435020416e-23
ko05322	Systemic lupus erythematosus	49/528	151/7206	3.99708504099e-20
ko03013	RNA transport	48/528	166/7206	2.06115255817e-17
ko03030	DNA replication	23/528	38/7206	2.70938272657e-17
ko03460	Fanconi anemia pathway	26/528	51/7206	7.47545739094e-17
ko04113	Meiosis - yeast	29/528	70/7206	1.36440756277e-15
ko03440	Homologous recombination	21/528	41/7206	6.69579412459e-14
ko03410	Base excision repair	20/528	38/7206	1.3595065779e-13
ko05034	Alcoholism	49/528	238/7206	1.54835752291e-11
ko03430	Mismatch repair	14/528	22/7206	2.01516299113e-11
ko03420	Nucleotide excision repair	18/528	46/7206	1.13707178201e-09
ko04144	Endocytosis	2/528	342/7206	1.82366160615e-09
ko00240	Pyrimidine metabolism	28/528	110/7206	3.02878188855e-09
ko03008	Ribosome biogenesis in eukaryotes	23/528	79/7206	4.88603209202e-09
ko03018	RNA degradation	23/528	84/7206	1.78959238612e-08
ko04014	Ras signaling pathway	2/528	279/7206	2.2335069314e-07
ko05203	Viral carcinogenesis	45/528	277/7206	3.69421349085e-07
ko04151	PI3K-Akt signaling pathway	7/528	390/7206	1.06558240926e-06
ko04015	Rap1 signaling pathway	3/528	278/7206	1.64826267099e-06
ko03015	mRNA surveillance pathway	20/528	93/7206	9.42201244447e-06
ko04072	Phospholipase D signaling pathway	1/528	197/7206	9.43762526293e-06
ko03022	Basal transcription factors	13/528	44/7206	9.48883753564e-06
ko04024	cAMP signaling pathway	4/528	279/7206	1.00513402615e-05
ko04060	Cytokine-cytokine receptor interaction	1/528	191/7206	1.37898704498e-05
ko04010	MAPK signaling pathway	6/528	321/7206	1.46458782243e-05
ko04932	Non-alcoholic fatty liver disease (NAFLD)	1/528	182/7206	1.97827868002e-05
ko04114	Oocyte meiosis	25/528	139/7206	2.11728106691e-05
ko05152	Tuberculosis	1/528	187/7206	2.13194948624e-05
ko04810	Regulation of actin cytoskeleton	4/528	264/7206	3.04018720285e-05
ko04723	Retrograde endocannabinoid signaling	1/528	175/7206	4.51390251577e-05
ko05166	HTLV-I infection	41/528	292/7206	4.54630918167e-05
ko04145	Phagosome	1/528	162/7206	9.53138090967e-05
ko04022	cGMP-PKG signaling pathway	3/528	216/7206	9.75247258306e-05
ko05202	Transcriptional misregulation in cancer	29/528	188/7206	0.000100947663213
ko04510	Focal adhesion	4/528	240/7206	0.000122590614762
ko04725	Cholinergic synapse	1/528	160/7206	0.000150991998322
ko04261	Adrenergic signaling in cardiomyocytes	3/528	205/7206	0.000200684577937
ko04921	Oxytocin signaling pathway	3/528	209/7206	0.000207907500347
ko04724	Glutamatergic synapse	1/528	152/7206	0.000209624522052
ko05205	Proteoglycans in cancer	6/528	271/7206	0.000306474886168
ko04120	Ubiquitin mediated proteolysis	22/528	138/7206	0.000426625778336
ko05167	Kaposi's sarcoma-associated herpesvirus infection	3/528	191/7206	0.000592844191742
ko04713	Circadian entrainment	1/528	136/7206	0.000671911730687
ko04726	Serotonergic synapse	1/528	137/7206	0.000684621635378
ko04360	Axon guidance	5/528	233/7206	0.000764399642716
ko04728	Dopaminergic synapse	3/528	185/7206	0.000839465125594
ko01200	Carbon metabolism	1/528	128/7206	0.000972218959758
ko04915	Estrogen signaling pathway	1/528	131/7206	0.000994228871621
ko04722	Neurotrophin signaling pathway	2/528	160/7206	0.000995918784873
ko04530	Tight junction	5/528	228/7206	0.00106902625309
ko04371	Apelin signaling pathway	3/528	177/7206	0.00118107478601
ko04270	Vascular smooth muscle contraction	2/528	154/7206	0.00141841341096
ko05012	Parkinson's disease	2/528	155/7206	0.00145142912663
ko05145	Toxoplasmosis	1/528	126/7206	0.00147113083914
ko04914	Progesterone-mediated oocyte maturation	17/528	104/7206	0.00168996901434
ko04750	Inflammatory mediator regulation of TRP channels	1/528	122/7206	0.00223465694572
ko04071	Sphingolipid signaling pathway	3/528	162/7206	0.00334758920095
ko04140	Autophagy - animal	3/528	164/7206	0.00342355850746
ko04141	Protein processing in endoplasmic reticulum	4/528	184/7206	0.00369778879854
ko05231	Choline metabolism in cancer	2/528	134/7206	0.00403640514477
ko04659	Th17 cell differentiation	1/528	106/7206	0.00447672921825
ko04727	GABAergic synapse	1/528	110/7206	0.00464265559839
ko04972	Pancreatic secretion	1/528	111/7206	0.00475893633817
ko04062	Chemokine signaling pathway	5/528	201/7206	0.00541410210963
ko05168	Herpes simplex infection	24/528	182/7206	0.00545111612275
ko05142	Chagas disease (American trypanosomiasis)	2/528	130/7206	0.00581384925718
ko04670	Leukocyte transendothelial migration	3/528	151/7206	0.00661471064774
ko05160	Hepatitis C	3/528	153/7206	0.00677343762211
ko05418	Fluid shear stress and atherosclerosis	4/528	173/7206	0.00711154281791
ko04658	Th1 and Th2 cell differentiation	1/528	96/7206	0.00951687614196
ko04971	Gastric acid secretion	1/528	98/7206	0.00968180547674
ko00564	Glycerophospholipid metabolism	1/528	99/7206	0.00985297129281
ko04115	p53 signaling pathway	12/528	74/7206	0.010524455868
ko04712	Circadian rhythm - plant	3/528	7/7206	0.0109523970466
ko04218	Cellular senescence	22/528	177/7206	0.0125567103975
ko04152	AMPK signaling pathway	4/528	161/7206	0.0133760840131
ko04611	Platelet activation	4/528	163/7206	0.0136967316211
ko05031	Amphetamine addiction	1/528	91/7206	0.0138741341618
ko04139	Mitophagy - yeast	7/528	37/7206	0.016316724387
ko04070	Phosphatidylinositol signaling system	2/528	112/7206	0.0165567715772
ko04630	Jak-STAT signaling pathway	3/528	132/7206	0.0177995158241
ko04931	Insulin resistance	3/528	137/7206	0.0186115423403
ko01230	Biosynthesis of amino acids	1/528	85/7206	0.0201095176639
ko04924	Renin secretion	1/528	86/7206	0.0202206086368
ko04918	Thyroid hormone synthesis	1/528	86/7206	0.0202206086368
ko00310	Lysine degradation	11/528	73/7206	0.0202210459966
ko05133	Pertussis	1/528	87/7206	0.0204464056894
ko04012	ErbB signaling pathway	2/528	109/7206	0.0239506943678
ko05032	Morphine addiction	2/528	110/7206	0.0243487286499
ko04540	Gap junction	3/528	128/7206	0.0247633096186
ko04217	Necroptosis	21/528	178/7206	0.0277807783073
ko04512	ECM-receptor interaction	1/528	79/7206	0.0291283439711
ko04740	Olfactory transduction	1/528	80/7206	0.029212471623
ko05230	Central carbon metabolism in cancer	1/528	81/7206	0.0294551875787
ko04138	Autophagy - yeast	1/528	81/7206	0.0294551875787
ko04520	Adherens junction	2/528	103/7206	0.0335540480946
ko04066	HIF-1 signaling pathway	3/528	123/7206	0.0343315805582
ko04210	Apoptosis	6/528	180/7206	0.0407523272898
ko05030	Cocaine addiction	1/528	73/7206	0.0421447949194
ko05014	Amyotrophic lateral sclerosis (ALS)	1/528	74/7206	0.0421695173095
ko04923	Regulation of lipolysis in adipocytes	1/528	77/7206	0.0435477061322
ko04330	Notch signaling pathway	9/528	62/7206	0.0442030095011
ko04730	Long-term depression	1/528	78/7206	0.0444388606782
ko05211	Renal cell carcinoma	2/528	96/7206	0.0464863279535
ko05132	Salmonella infection	2/528	98/7206	0.0474831327215
ko04720	Long-term potentiation	2/528	99/7206	0.0482510556556