ko pathway ratio_in_study ratio_in_pop p_value ko04360 Axon guidance 36/404 233/7206 1.93250056384e-08 ko05032 Morphine addiction 21/404 110/7206 5.77314222298e-07 ko04010 MAPK signaling pathway 39/404 321/7206 4.43432272401e-06 ko05033 Nicotine addiction 13/404 56/7206 9.23998652129e-06 ko04024 cAMP signaling pathway 34/404 279/7206 1.43568398089e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/404 14/7206 6.11369764989e-05 ko04725 Cholinergic synapse 22/404 160/7206 7.67826995544e-05 ko04144 Endocytosis 37/404 342/7206 9.32209105192e-05 ko04721 Synaptic vesicle cycle 14/404 80/7206 0.000121655120625 ko04930 Type II diabetes mellitus 11/404 54/7206 0.000160999529149 ko04728 Dopaminergic synapse 23/404 185/7206 0.000269425431329 ko04514 Cell adhesion molecules (CAMs) 18/404 130/7206 0.000313002235607 ko04072 Phospholipase D signaling pathway 24/404 197/7206 0.000379142680635 ko04727 GABAergic synapse 16/404 110/7206 0.000381234567195 ko00562 Inositol phosphate metabolism 14/404 89/7206 0.000388028462198 ko04070 Phosphatidylinositol signaling system 16/404 112/7206 0.000468804154336 ko04713 Circadian entrainment 18/404 136/7206 0.000547270342562 ko04550 Signaling pathways regulating pluripotency of stem cells 20/404 165/7206 0.00093107638574 ko04724 Glutamatergic synapse 19/404 152/7206 0.000936021935088 ko04723 Retrograde endocannabinoid signaling 21/404 175/7206 0.00116271735992 ko03013 RNA transport 1/404 166/7206 0.00162011472302 ko04071 Sphingolipid signaling pathway 19/404 162/7206 0.00256376222432 ko05210 Colorectal cancer 12/404 86/7206 0.00287053695353 ko04014 Ras signaling pathway 28/404 279/7206 0.00306712811258 ko04911 Insulin secretion 15/404 117/7206 0.00325352132568 ko05322 Systemic lupus erythematosus 1/404 151/7206 0.00339552654477 ko04923 Regulation of lipolysis in adipocytes 11/404 77/7206 0.00352314753474 ko04391 Hippo signaling pathway - fly 12/404 90/7206 0.00420246254325 ko04080 Neuroactive ligand-receptor interaction 37/404 423/7206 0.0061719731242 ko04668 TNF signaling pathway 14/404 120/7206 0.00793173654008 ko04921 Oxytocin signaling pathway 21/404 209/7206 0.00863966945794 ko04917 Prolactin signaling pathway 11/404 87/7206 0.00895356196819 ko04710 Circadian rhythm 7/404 43/7206 0.00922688574101 ko00190 Oxidative phosphorylation 1/404 127/7206 0.0101011159045 ko00515 Mannose type O-glycan biosynthesis 5/404 25/7206 0.01130760363 ko04931 Insulin resistance 15/404 137/7206 0.0126981636476 ko04390 Hippo signaling pathway 19/404 188/7206 0.0143291792282 ko04914 Progesterone-mediated oocyte maturation 12/404 104/7206 0.0154967525646 ko04925 Aldosterone synthesis and secretion 12/404 105/7206 0.0163323097432 ko04015 Rap1 signaling pathway 25/404 278/7206 0.0164708167186 ko04915 Estrogen signaling pathway 14/404 131/7206 0.0190181933329 ko05030 Cocaine addiction 9/404 73/7206 0.0201094508464 ko04012 ErbB signaling pathway 12/404 109/7206 0.0203016801054 ko04933 AGE-RAGE signaling pathway in diabetic complications 14/404 135/7206 0.0222096732921 ko04722 Neurotrophin signaling pathway 16/404 160/7206 0.0222112661973 ko05221 Acute myeloid leukemia 8/404 63/7206 0.023562989769 ko05220 Chronic myeloid leukemia 10/404 85/7206 0.0271061416589 ko04011 MAPK signaling pathway - yeast 7/404 53/7206 0.0273891463462 ko04371 Apelin signaling pathway 17/404 177/7206 0.0293311995836 ko04261 Adrenergic signaling in cardiomyocytes 19/404 205/7206 0.0294454408289 ko04711 Circadian rhythm - fly 3/404 13/7206 0.0328544822487 ko04145 Phagosome 3/404 162/7206 0.0358372146346 ko04664 Fc epsilon RI signaling pathway 9/404 77/7206 0.0389816844984 ko04730 Long-term depression 9/404 78/7206 0.0404428822442 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 9/404 79/7206 0.0420518196736 ko04962 Vasopressin-regulated water reabsorption 7/404 58/7206 0.0421721667096 ko04961 Endocrine and other factor-regulated calcium reabsorption 7/404 59/7206 0.0456461636259 ko05230 Central carbon metabolism in cancer 9/404 81/7206 0.0457143306438 ko04022 cGMP-PKG signaling pathway 19/404 216/7206 0.0490805482653