ko pathway ratio_in_study ratio_in_pop p_value ko05033 Nicotine addiction 34/630 56/7206 1.5214155781e-22 ko04721 Synaptic vesicle cycle 38/630 80/7206 6.11359528585e-20 ko04724 Glutamatergic synapse 52/630 152/7206 5.50648594811e-19 ko04080 Neuroactive ligand-receptor interaction 86/630 423/7206 2.24677552289e-14 ko04727 GABAergic synapse 38/630 110/7206 2.48666887854e-14 ko04728 Dopaminergic synapse 49/630 185/7206 5.21877291205e-13 ko05032 Morphine addiction 36/630 110/7206 7.90782705763e-13 ko04723 Retrograde endocannabinoid signaling 47/630 175/7206 9.17961756845e-13 ko04725 Cholinergic synapse 43/630 160/7206 8.68731496911e-12 ko04713 Circadian entrainment 39/630 136/7206 9.42632289432e-12 ko04911 Insulin secretion 33/630 117/7206 6.2592016459e-10 ko04360 Axon guidance 49/630 233/7206 3.93168305786e-09 ko04024 cAMP signaling pathway 55/630 279/7206 6.51374724687e-09 ko04726 Serotonergic synapse 32/630 137/7206 1.62110336088e-07 ko04744 Phototransduction 14/630 36/7206 8.14992664795e-07 ko04514 Cell adhesion molecules (CAMs) 29/630 130/7206 1.7086832619e-06 ko04261 Adrenergic signaling in cardiomyocytes 39/630 205/7206 3.41288328525e-06 ko05031 Amphetamine addiction 22/630 91/7206 7.8024754067e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 19/630 74/7206 1.28498292028e-05 ko04010 MAPK signaling pathway 51/630 321/7206 2.63778286776e-05 ko04921 Oxytocin signaling pathway 37/630 209/7206 2.83478938747e-05 ko05203 Viral carcinogenesis 7/630 277/7206 3.02456483728e-05 ko04720 Long-term potentiation 22/630 99/7206 3.24601026343e-05 ko04966 Collecting duct acid secretion 10/630 26/7206 3.54188844408e-05 ko05030 Cocaine addiction 18/630 73/7206 3.91403889055e-05 ko00604 Glycosphingolipid biosynthesis - ganglio series 7/630 14/7206 7.50467967202e-05 ko04120 Ubiquitin mediated proteolysis 1/630 138/7206 9.07120716859e-05 ko04964 Proximal tubule bicarbonate reclamation 10/630 29/7206 0.000104869149347 ko04970 Salivary secretion 20/630 95/7206 0.000162812887014 ko05322 Systemic lupus erythematosus 2/630 151/7206 0.00020290754612 ko04972 Pancreatic secretion 22/630 111/7206 0.000233362326135 ko05164 Influenza A 3/630 167/7206 0.000267260764532 ko03040 Spliceosome 2/630 145/7206 0.00029182017987 ko03013 RNA transport 3/630 166/7206 0.000395735371837 ko04060 Cytokine-cytokine receptor interaction 5/630 191/7206 0.00100636207905 ko04621 NOD-like receptor signaling pathway 4/630 157/7206 0.0024891762277 ko05110 Vibrio cholerae infection 13/630 63/7206 0.00267947099724 ko04146 Peroxisome 1/630 89/7206 0.00423299514223 ko05168 Herpes simplex infection 6/630 182/7206 0.00500608413139 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/630 182/7206 0.00500608413139 ko04260 Cardiac muscle contraction 17/630 98/7206 0.00578381547088 ko04971 Gastric acid secretion 17/630 98/7206 0.00578381547088 ko01200 Carbon metabolism 3/630 128/7206 0.00642057674133 ko04022 cGMP-PKG signaling pathway 31/630 216/7206 0.00657645713518 ko04020 Calcium signaling pathway 36/630 265/7206 0.00741804371834 ko04730 Long-term depression 14/630 78/7206 0.00779455703073 ko05205 Proteoglycans in cancer 12/630 271/7206 0.00816824309441 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 14/630 79/7206 0.00857655596285 ko05162 Measles 3/630 120/7206 0.00878565500896 ko04742 Taste transduction 12/630 61/7206 0.00946505163909 ko04141 Protein processing in endoplasmic reticulum 7/630 184/7206 0.0117861682387 ko04612 Antigen processing and presentation 1/630 77/7206 0.0133526260369 ko05120 Epithelial cell signaling in Helicobacter pylori infection 15/630 92/7206 0.0151005297362 ko04961 Endocrine and other factor-regulated calcium reabsorption 11/630 59/7206 0.016527107364 ko04110 Cell cycle 5/630 145/7206 0.0171772840753 ko00310 Lysine degradation 1/630 73/7206 0.0196457403389 ko04072 Phospholipase D signaling pathway 27/630 197/7206 0.0202252668658 ko04540 Gap junction 19/630 128/7206 0.0251140632769 ko04976 Bile secretion 13/630 80/7206 0.0260767047417 ko00603 Glycosphingolipid biosynthesis - globo and isoglobo series 3/630 8/7206 0.0266706081198 ko04973 Carbohydrate digestion and absorption 8/630 42/7206 0.0268761135794 ko04014 Ras signaling pathway 35/630 279/7206 0.0297637920618 ko03018 RNA degradation 2/630 84/7206 0.0318059499459 ko04145 Phagosome 22/630 162/7206 0.0340937738887 ko04140 Autophagy - animal 7/630 164/7206 0.0359058386157 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 4/630 15/7206 0.0362455519671 ko00512 Mucin type O-glycan biosynthesis 6/630 29/7206 0.0364288873422 ko04015 Rap1 signaling pathway 34/630 278/7206 0.0396490471253 ko00561 Glycerolipid metabolism 1/630 63/7206 0.0410893165557 ko04640 Hematopoietic cell lineage 1/630 64/7206 0.0416938437949 ko05169 Epstein-Barr virus infection 10/630 206/7206 0.0446543299897 ko04064 NF-kappa B signaling pathway 3/630 96/7206 0.0453417135797