ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 58/554 152/7206 8.78849240671e-27 ko05033 Nicotine addiction 33/554 56/7206 4.0871633357e-23 ko04080 Neuroactive ligand-receptor interaction 91/554 423/7206 9.34222948747e-21 ko04721 Synaptic vesicle cycle 36/554 80/7206 7.70989652114e-20 ko04728 Dopaminergic synapse 52/554 185/7206 2.84982817217e-17 ko04727 GABAergic synapse 38/554 110/7206 3.58166663032e-16 ko04723 Retrograde endocannabinoid signaling 48/554 175/7206 1.48019037678e-15 ko05032 Morphine addiction 37/554 110/7206 2.38989501486e-15 ko04713 Circadian entrainment 40/554 136/7206 2.95884650867e-14 ko04726 Serotonergic synapse 35/554 137/7206 1.05300883252e-10 ko04725 Cholinergic synapse 38/554 160/7206 1.69082393033e-10 ko04024 cAMP signaling pathway 51/554 279/7206 3.15681459637e-09 ko04911 Insulin secretion 29/554 117/7206 9.24583234176e-09 ko05031 Amphetamine addiction 25/554 91/7206 1.0544973766e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 22/554 74/7206 1.6697367872e-08 ko04744 Phototransduction 15/554 36/7206 1.96322229951e-08 ko05030 Cocaine addiction 21/554 73/7206 6.71134531412e-08 ko04720 Long-term potentiation 23/554 99/7206 1.11411005224e-06 ko04261 Adrenergic signaling in cardiomyocytes 36/554 205/7206 2.98981767418e-06 ko04514 Cell adhesion molecules (CAMs) 26/554 130/7206 4.6358784413e-06 ko04060 Cytokine-cytokine receptor interaction 1/554 191/7206 5.92540936145e-06 ko04010 MAPK signaling pathway 47/554 321/7206 1.34733951778e-05 ko04921 Oxytocin signaling pathway 34/554 209/7206 2.78757371964e-05 ko04742 Taste transduction 15/554 61/7206 4.07778209922e-05 ko05164 Influenza A 1/554 167/7206 4.42882720003e-05 ko04966 Collecting duct acid secretion 9/554 26/7206 8.36808056521e-05 ko04970 Salivary secretion 19/554 95/7206 8.85868695448e-05 ko04360 Axon guidance 35/554 233/7206 0.000132304948933 ko05322 Systemic lupus erythematosus 1/554 151/7206 0.000141473917891 ko03040 Spliceosome 1/554 145/7206 0.000205667871279 ko04730 Long-term depression 16/554 78/7206 0.000232170860093 ko04120 Ubiquitin mediated proteolysis 1/554 138/7206 0.000299350242438 ko05110 Vibrio cholerae infection 13/554 63/7206 0.000830453818873 ko04972 Pancreatic secretion 19/554 111/7206 0.000848110539933 ko05203 Viral carcinogenesis 8/554 277/7206 0.00113443978434 ko04964 Proximal tubule bicarbonate reclamation 8/554 29/7206 0.00116898022223 ko05205 Proteoglycans in cancer 8/554 271/7206 0.00152611743643 ko03013 RNA transport 3/554 166/7206 0.00166980529932 ko04022 cGMP-PKG signaling pathway 29/554 216/7206 0.00266822285418 ko04932 Non-alcoholic fatty liver disease (NAFLD) 4/554 182/7206 0.00266935132935 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/554 14/7206 0.0029424936943 ko01200 Carbon metabolism 2/554 128/7206 0.00398524405594 ko04350 TGF-beta signaling pathway 1/554 103/7206 0.00444127445295 ko05120 Epithelial cell signaling in Helicobacter pylori infection 15/554 92/7206 0.00471511507895 ko05034 Alcoholism 30/554 238/7206 0.00620752245429 ko04020 Calcium signaling pathway 33/554 265/7206 0.00638707821554 ko04510 Focal adhesion 8/554 240/7206 0.00651005026927 ko05168 Herpes simplex infection 5/554 182/7206 0.00706476229582 ko04145 Phagosome 22/554 162/7206 0.0101019325293 ko04540 Gap junction 18/554 128/7206 0.0110406730106 ko04146 Peroxisome 1/554 89/7206 0.0141306738389 ko05169 Epstein-Barr virus infection 7/554 206/7206 0.0161634729101 ko04141 Protein processing in endoplasmic reticulum 6/554 184/7206 0.0169892225979 ko05166 HTLV-I infection 12/554 292/7206 0.017874859597 ko04260 Cardiac muscle contraction 14/554 98/7206 0.0205766253566 ko04971 Gastric acid secretion 14/554 98/7206 0.0205766253566 ko03018 RNA degradation 1/554 84/7206 0.020631472472 ko00512 Mucin type O-glycan biosynthesis 6/554 29/7206 0.0208047932334 ko04924 Renin secretion 13/554 86/7206 0.0217505452648 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/554 59/7206 0.0222718979226 ko04745 Phototransduction - fly 7/554 38/7206 0.0238204593586 ko04611 Platelet activation 5/554 163/7206 0.0242216563926 ko05323 Rheumatoid arthritis 13/554 89/7206 0.0244058632543 ko01524 Platinum drug resistance 1/554 76/7206 0.0289087939678 ko04915 Estrogen signaling pathway 17/554 131/7206 0.0299530661832 ko03008 Ribosome biogenesis in eukaryotes 1/554 79/7206 0.0300710986295 ko04621 NOD-like receptor signaling pathway 5/554 157/7206 0.0323374780354 ko05146 Amoebiasis 2/554 99/7206 0.0336867625792 ko04071 Sphingolipid signaling pathway 20/554 162/7206 0.0349401305069 ko04014 Ras signaling pathway 31/554 279/7206 0.0380237770189 ko04925 Aldosterone synthesis and secretion 14/554 105/7206 0.0397843797267 ko04072 Phospholipase D signaling pathway 23/554 197/7206 0.0409334756175 ko04962 Vasopressin-regulated water reabsorption 9/554 58/7206 0.0410946484906 ko04214 Apoptosis - fly 1/554 72/7206 0.0422877614662