ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	177/1024	423/7206	3.35746515488e-47
ko05033	Nicotine addiction	46/1024	56/7206	3.67159648025e-30
ko04724	Glutamatergic synapse	78/1024	152/7206	6.14194151177e-28
ko05032	Morphine addiction	63/1024	110/7206	2.95621099298e-26
ko04727	GABAergic synapse	59/1024	110/7206	1.18194031433e-22
ko04713	Circadian entrainment	62/1024	136/7206	5.21811514478e-19
ko04723	Retrograde endocannabinoid signaling	72/1024	175/7206	8.93249730171e-19
ko04728	Dopaminergic synapse	74/1024	185/7206	1.97762944057e-18
ko04725	Cholinergic synapse	63/1024	160/7206	1.84475015593e-15
ko04024	cAMP signaling pathway	89/1024	279/7206	1.36801980658e-14
ko04721	Synaptic vesicle cycle	39/1024	80/7206	1.3661090333e-13
ko04020	Calcium signaling pathway	83/1024	265/7206	4.97006616499e-13
ko04911	Insulin secretion	48/1024	117/7206	7.46073029939e-13
ko04726	Serotonergic synapse	53/1024	137/7206	7.79700647277e-13
ko04742	Taste transduction	32/1024	61/7206	1.68606393602e-12
ko04921	Oxytocin signaling pathway	65/1024	209/7206	2.38238343138e-10
ko04261	Adrenergic signaling in cardiomyocytes	64/1024	205/7206	3.13506904162e-10
ko04360	Axon guidance	67/1024	233/7206	4.75385851506e-09
ko03040	Spliceosome	1/1024	145/7206	9.24208021092e-09
ko05031	Amphetamine addiction	34/1024	91/7206	2.96823704952e-08
ko04744	Phototransduction	19/1024	36/7206	5.26530151578e-08
ko05030	Cocaine addiction	28/1024	73/7206	2.61054766718e-07
ko04970	Salivary secretion	33/1024	95/7206	3.51442958262e-07
ko05203	Viral carcinogenesis	14/1024	277/7206	1.02691256079e-06
ko04720	Long-term potentiation	33/1024	99/7206	1.26363455036e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1024	74/7206	1.3610318072e-06
ko05164	Influenza A	5/1024	167/7206	1.61027678008e-06
ko04010	MAPK signaling pathway	77/1024	321/7206	1.67024093892e-06
ko03013	RNA transport	5/1024	166/7206	2.45161431012e-06
ko05322	Systemic lupus erythematosus	4/1024	151/7206	2.63960137373e-06
ko05168	Herpes simplex infection	7/1024	182/7206	7.20454230199e-06
ko04022	cGMP-PKG signaling pathway	55/1024	216/7206	1.00014282932e-05
ko04925	Aldosterone synthesis and secretion	32/1024	105/7206	1.45171035738e-05
ko04514	Cell adhesion molecules (CAMs)	37/1024	130/7206	1.94156713203e-05
ko04972	Pancreatic secretion	32/1024	111/7206	5.11418247925e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1024	79/7206	6.12854900276e-05
ko04072	Phospholipase D signaling pathway	49/1024	197/7206	6.77666665157e-05
ko04060	Cytokine-cytokine receptor interaction	10/1024	191/7206	8.81062132944e-05
ko04070	Phosphatidylinositol signaling system	32/1024	112/7206	9.27760438954e-05
ko04971	Gastric acid secretion	29/1024	98/7206	0.000100021641425
ko03008	Ribosome biogenesis in eukaryotes	1/1024	79/7206	0.000129308454657
ko04260	Cardiac muscle contraction	28/1024	98/7206	0.00019571985557
ko04730	Long-term depression	24/1024	78/7206	0.000213543062756
ko04141	Protein processing in endoplasmic reticulum	10/1024	184/7206	0.00023360521112
ko04621	NOD-like receptor signaling pathway	8/1024	157/7206	0.000444105583099
ko05414	Dilated cardiomyopathy	30/1024	112/7206	0.000511015488011
ko04610	Complement and coagulation cascades	2/1024	79/7206	0.00095365851891
ko05169	Epstein-Barr virus infection	14/1024	206/7206	0.00111789117702
ko04146	Peroxisome	3/1024	89/7206	0.00117758113223
ko05205	Proteoglycans in cancer	21/1024	271/7206	0.00132237327438
ko04612	Antigen processing and presentation	2/1024	77/7206	0.00143748314399
ko04745	Phototransduction - fly	13/1024	38/7206	0.00153245071832
ko04540	Gap junction	31/1024	128/7206	0.00204543482146
ko05162	Measles	6/1024	120/7206	0.00213664798983
ko04924	Renin secretion	23/1024	86/7206	0.00262079226622
ko04120	Ubiquitin mediated proteolysis	8/1024	138/7206	0.00284305834545
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1024	100/7206	0.00358901518056
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1024	182/7206	0.00485131680058
ko00590	Arachidonic acid metabolism	1/1024	52/7206	0.0049138332795
ko05016	Huntington's disease	17/1024	215/7206	0.00535861738033
ko04014	Ras signaling pathway	56/1024	279/7206	0.00647710434325
ko04966	Collecting duct acid secretion	9/1024	26/7206	0.00734474509959
ko05133	Pertussis	4/1024	87/7206	0.00773241991989
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1024	59/7206	0.00795597703627
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1024	14/7206	0.00878505230427
ko04930	Type II diabetes mellitus	15/1024	54/7206	0.00920758650871
ko04740	Olfactory transduction	20/1024	80/7206	0.00922793049478
ko00310	Lysine degradation	3/1024	73/7206	0.0103139154246
ko04217	Necroptosis	14/1024	178/7206	0.0120878703278
ko00240	Pyrimidine metabolism	7/1024	110/7206	0.013169985476
ko04964	Proximal tubule bicarbonate reclamation	9/1024	29/7206	0.0158716792186
ko03022	Basal transcription factors	1/1024	44/7206	0.0160965348752
ko00071	Fatty acid degradation	1/1024	45/7206	0.0163658917813
ko05110	Vibrio cholerae infection	16/1024	63/7206	0.0170160989224
ko00620	Pyruvate metabolism	1/1024	46/7206	0.017036974539
ko03420	Nucleotide excision repair	1/1024	46/7206	0.017036974539
ko00480	Glutathione metabolism	2/1024	55/7206	0.0189658697909
ko04657	IL-17 signaling pathway	5/1024	87/7206	0.0197259346162
ko00562	Inositol phosphate metabolism	21/1024	89/7206	0.0204462910448
ko04110	Cell cycle	11/1024	145/7206	0.0215886437573
ko04976	Bile secretion	19/1024	80/7206	0.0225044478178
ko04915	Estrogen signaling pathway	28/1024	131/7206	0.0225980357681
ko04064	NF-kappa B signaling pathway	6/1024	96/7206	0.0258531681874
ko03018	RNA degradation	5/1024	84/7206	0.0268794245002
ko04622	RIG-I-like receptor signaling pathway	3/1024	62/7206	0.0282904990103
ko00280	Valine, leucine and isoleucine degradation	2/1024	54/7206	0.0285310078201
ko04640	Hematopoietic cell lineage	3/1024	64/7206	0.0288520271685
ko04750	Inflammatory mediator regulation of TRP channels	26/1024	122/7206	0.0350544340388
ko03410	Base excision repair	1/1024	38/7206	0.0352347696392
ko05161	Hepatitis B	15/1024	173/7206	0.0356220075561
ko05012	Parkinson's disease	13/1024	155/7206	0.0357847793551
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1024	40/7206	0.0368657879142
ko05131	Shigellosis	5/1024	82/7206	0.0369179627675
ko04371	Apelin signaling pathway	35/1024	177/7206	0.0378675626113
ko05215	Prostate cancer	8/1024	111/7206	0.0383918827543
ko01200	Carbon metabolism	10/1024	128/7206	0.0398494527175
ko04620	Toll-like receptor signaling pathway	7/1024	100/7206	0.0419279844423
ko04918	Thyroid hormone synthesis	19/1024	86/7206	0.0426116901879