ko pathway ratio_in_study ratio_in_pop p_value ko04911 Insulin secretion 19/197 117/7206 2.76842597381e-10 ko04713 Circadian entrainment 20/197 136/7206 5.74348389526e-10 ko04724 Glutamatergic synapse 21/197 152/7206 6.81326857754e-10 ko04728 Dopaminergic synapse 20/197 185/7206 1.25089466027e-07 ko04024 cAMP signaling pathway 25/197 279/7206 1.29980041828e-07 ko04725 Cholinergic synapse 18/197 160/7206 3.03129249834e-07 ko04261 Adrenergic signaling in cardiomyocytes 20/197 205/7206 6.71372610094e-07 ko04720 Long-term potentiation 13/197 99/7206 2.51696486204e-06 ko05031 Amphetamine addiction 12/197 91/7206 5.92322389591e-06 ko04745 Phototransduction - fly 8/197 38/7206 6.54372665303e-06 ko04971 Gastric acid secretion 12/197 98/7206 1.28969542407e-05 ko04970 Salivary secretion 11/197 95/7206 5.06097664376e-05 ko04721 Synaptic vesicle cycle 10/197 80/7206 5.77729260909e-05 ko04960 Aldosterone-regulated sodium reabsorption 7/197 41/7206 0.000104774531868 ko04964 Proximal tubule bicarbonate reclamation 6/197 29/7206 0.000108665849286 ko04973 Carbohydrate digestion and absorption 7/197 42/7206 0.000122853780151 ko04925 Aldosterone synthesis and secretion 11/197 105/7206 0.000127249325457 ko04921 Oxytocin signaling pathway 16/197 209/7206 0.000179611459554 ko04727 GABAergic synapse 11/197 110/7206 0.000193316200955 ko04070 Phosphatidylinositol signaling system 11/197 112/7206 0.000226892303965 ko04726 Serotonergic synapse 12/197 137/7206 0.000347422595792 ko04972 Pancreatic secretion 10/197 111/7206 0.000868092118781 ko05014 Amyotrophic lateral sclerosis (ALS) 8/197 74/7206 0.000869177041794 ko04961 Endocrine and other factor-regulated calcium reabsorption 7/197 59/7206 0.00104956245445 ko04626 Plant-pathogen interaction 4/197 18/7206 0.00122689064969 ko04020 Calcium signaling pathway 17/197 265/7206 0.00145686797189 ko04080 Neuroactive ligand-receptor interaction 23/197 423/7206 0.00168586636579 ko04022 cGMP-PKG signaling pathway 14/197 216/7206 0.00230587146892 ko04918 Thyroid hormone synthesis 8/197 86/7206 0.00231555282022 ko04723 Retrograde endocannabinoid signaling 12/197 175/7206 0.00296167342645 ko05032 Morphine addiction 9/197 110/7206 0.00304813461738 ko05033 Nicotine addiction 6/197 56/7206 0.00402867012003 ko04015 Rap1 signaling pathway 16/197 278/7206 0.00419875264435 ko04978 Mineral absorption 5/197 40/7206 0.00438803308116 ko04966 Collecting duct acid secretion 4/197 26/7206 0.00505297858756 ko04260 Cardiac muscle contraction 8/197 98/7206 0.00520199037861 ko04730 Long-term depression 7/197 78/7206 0.00525866789146 ko04919 Thyroid hormone signaling pathway 10/197 143/7206 0.00566282242385 ko04360 Axon guidance 14/197 233/7206 0.00598772053767 ko04750 Inflammatory mediator regulation of TRP channels 9/197 122/7206 0.00605151441044 ko05110 Vibrio cholerae infection 6/197 63/7206 0.00720362200875 ko04540 Gap junction 9/197 128/7206 0.00822559296936 ko04924 Renin secretion 7/197 86/7206 0.00891246839402 ko04371 Apelin signaling pathway 11/197 177/7206 0.00904170123533 ko00562 Inositol phosphate metabolism 7/197 89/7206 0.0106751217284 ko04072 Phospholipase D signaling pathway 12/197 197/7206 0.0115429403437 ko04722 Neurotrophin signaling pathway 10/197 160/7206 0.0121097684618 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/197 92/7206 0.0126788251511 ko04014 Ras signaling pathway 15/197 279/7206 0.0127151775979 ko04071 Sphingolipid signaling pathway 10/197 162/7206 0.013132946114 ko05030 Cocaine addiction 6/197 73/7206 0.0144306216703 ko04916 Melanogenesis 9/197 142/7206 0.0155724353798 ko04912 GnRH signaling pathway 8/197 122/7206 0.0183248695205 ko04066 HIF-1 signaling pathway 8/197 123/7206 0.0191558889251 ko05214 Glioma 6/197 79/7206 0.0206163067289 ko04976 Bile secretion 6/197 80/7206 0.0217980824179 ko04740 Olfactory transduction 6/197 80/7206 0.0217980824179 ko04922 Glucagon signaling pathway 8/197 128/7206 0.0237188072266 ko04062 Chemokine signaling pathway 11/197 201/7206 0.0251711226234 ko05010 Alzheimer's disease 11/197 202/7206 0.0257894296768 ko04915 Estrogen signaling pathway 8/197 131/7206 0.0267973130023 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/197 1/7206 0.0273383291702 ko05323 Rheumatoid arthritis 6/197 89/7206 0.0345329260362 ko05152 Tuberculosis 10/197 187/7206 0.0372679609409 ko04145 Phagosome 9/197 162/7206 0.0438431759382 ko04974 Protein digestion and absorption 6/197 96/7206 0.047213115685 ko04068 FoxO signaling pathway 9/197 167/7206 0.0484106469811