ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	187/1038	423/7206	1.69701330689e-53
ko04724	Glutamatergic synapse	85/1038	152/7206	1.29825739045e-33
ko05033	Nicotine addiction	47/1038	56/7206	2.32115537893e-31
ko04727	GABAergic synapse	62/1038	110/7206	5.32219135747e-25
ko05032	Morphine addiction	62/1038	110/7206	5.32219135747e-25
ko04713	Circadian entrainment	70/1038	136/7206	6.70406026143e-25
ko04721	Synaptic vesicle cycle	50/1038	80/7206	3.38212037577e-23
ko04728	Dopaminergic synapse	80/1038	185/7206	5.05358847666e-22
ko04725	Cholinergic synapse	72/1038	160/7206	3.84018688104e-21
ko04723	Retrograde endocannabinoid signaling	73/1038	175/7206	4.3583761822e-19
ko04024	cAMP signaling pathway	97/1038	279/7206	2.50117206059e-18
ko04742	Taste transduction	35/1038	61/7206	5.84651680846e-15
ko04020	Calcium signaling pathway	87/1038	265/7206	8.5660939636e-15
ko04726	Serotonergic synapse	56/1038	137/7206	1.91140488109e-14
ko04921	Oxytocin signaling pathway	73/1038	209/7206	4.15037489863e-14
ko04911	Insulin secretion	50/1038	117/7206	6.16517885858e-14
ko04744	Phototransduction	25/1038	36/7206	8.64832853903e-14
ko04720	Long-term potentiation	42/1038	99/7206	8.74192124879e-12
ko04261	Adrenergic signaling in cardiomyocytes	67/1038	205/7206	2.0096040795e-11
ko05031	Amphetamine addiction	39/1038	91/7206	3.3600985456e-11
ko04970	Salivary secretion	37/1038	95/7206	2.78882182329e-09
ko03040	Spliceosome	1/1038	145/7206	5.64333324456e-09
ko05203	Viral carcinogenesis	11/1038	277/7206	1.34821525344e-08
ko04740	Olfactory transduction	30/1038	80/7206	2.387196588e-07
ko04060	Cytokine-cytokine receptor interaction	6/1038	191/7206	3.12649493873e-07
ko05030	Cocaine addiction	28/1038	73/7206	3.48243938696e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1038	74/7206	4.8447469723e-07
ko05168	Herpes simplex infection	6/1038	182/7206	9.45619734241e-07
ko05164	Influenza A	5/1038	167/7206	1.08702224705e-06
ko04971	Gastric acid secretion	33/1038	98/7206	1.30376262821e-06
ko04360	Axon guidance	61/1038	233/7206	1.5397884154e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1038	79/7206	2.24924677782e-06
ko04966	Collecting duct acid secretion	14/1038	26/7206	2.69578176571e-06
ko04925	Aldosterone synthesis and secretion	34/1038	105/7206	3.42314983425e-06
ko04010	MAPK signaling pathway	76/1038	321/7206	6.31596352069e-06
ko04022	cGMP-PKG signaling pathway	56/1038	216/7206	7.00035188902e-06
ko05322	Systemic lupus erythematosus	5/1038	151/7206	1.01286640283e-05
ko04514	Cell adhesion molecules (CAMs)	38/1038	130/7206	1.12944396742e-05
ko04120	Ubiquitin mediated proteolysis	4/1038	138/7206	1.19358729994e-05
ko04260	Cardiac muscle contraction	31/1038	98/7206	1.37913270204e-05
ko04730	Long-term depression	26/1038	78/7206	2.33394488331e-05
ko03013	RNA transport	7/1038	166/7206	2.7548168065e-05
ko04745	Phototransduction - fly	16/1038	38/7206	2.98561015045e-05
ko04924	Renin secretion	27/1038	86/7206	6.51680864443e-05
ko04621	NOD-like receptor signaling pathway	7/1038	157/7206	7.72397738352e-05
ko05414	Dilated cardiomyopathy	32/1038	112/7206	0.000101907411061
ko04540	Gap junction	35/1038	128/7206	0.0001091536821
ko05169	Epstein-Barr virus infection	12/1038	206/7206	0.000117157929718
ko05110	Vibrio cholerae infection	21/1038	63/7206	0.000168211999248
ko04972	Pancreatic secretion	31/1038	111/7206	0.000180415021269
ko04070	Phosphatidylinositol signaling system	31/1038	112/7206	0.000204292464947
ko04110	Cell cycle	7/1038	145/7206	0.00029681845267
ko04626	Plant-pathogen interaction	9/1038	18/7206	0.000367583035969
ko05205	Proteoglycans in cancer	20/1038	271/7206	0.000393368442062
ko04141	Protein processing in endoplasmic reticulum	11/1038	184/7206	0.000407227040891
ko04072	Phospholipase D signaling pathway	47/1038	197/7206	0.0004087240411
ko05162	Measles	5/1038	120/7206	0.000531559807111
ko04612	Antigen processing and presentation	2/1038	77/7206	0.000934647473117
ko03008	Ribosome biogenesis in eukaryotes	2/1038	79/7206	0.000976262478653
ko05161	Hepatitis B	11/1038	173/7206	0.00134930679812
ko05140	Leishmaniasis	2/1038	75/7206	0.00137969478016
ko05166	HTLV-I infection	24/1038	292/7206	0.00155471486974
ko04014	Ras signaling pathway	59/1038	279/7206	0.0016958879757
ko04064	NF-kappa B signaling pathway	4/1038	96/7206	0.00188846749205
ko04915	Estrogen signaling pathway	32/1038	131/7206	0.00228797071583
ko00480	Glutathione metabolism	1/1038	55/7206	0.00325441834346
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1038	59/7206	0.0041772674999
ko04964	Proximal tubule bicarbonate reclamation	10/1038	29/7206	0.00545541896239
ko04146	Peroxisome	4/1038	89/7206	0.00551046163126
ko04976	Bile secretion	21/1038	80/7206	0.00560837894711
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1038	100/7206	0.00573739997477
ko04750	Inflammatory mediator regulation of TRP channels	29/1038	122/7206	0.00577549551681
ko04640	Hematopoietic cell lineage	2/1038	64/7206	0.00633251511272
ko00310	Lysine degradation	3/1038	73/7206	0.00704427036987
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1038	182/7206	0.00723740206445
ko00330	Arginine and proline metabolism	2/1038	61/7206	0.00915887319858
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1038	14/7206	0.00939247896891
ko04330	Notch signaling pathway	2/1038	62/7206	0.00949274730854
ko04214	Apoptosis - fly	3/1038	72/7206	0.0102275469702
ko04350	TGF-beta signaling pathway	6/1038	103/7206	0.0102341082799
ko03420	Nucleotide excision repair	1/1038	46/7206	0.0107585158493
ko00260	Glycine, serine and threonine metabolism	1/1038	48/7206	0.0112667663238
ko04630	Jak-STAT signaling pathway	9/1038	132/7206	0.0116232878471
ko00240	Pyrimidine metabolism	7/1038	110/7206	0.013115539603
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1038	92/7206	0.0155556452008
ko03022	Basal transcription factors	1/1038	44/7206	0.016095156044
ko05144	Malaria	1/1038	45/7206	0.0166102353792
ko00071	Fatty acid degradation	1/1038	45/7206	0.0166102353792
ko04912	GnRH signaling pathway	27/1038	122/7206	0.018792276331
ko05321	Inflammatory bowel disease (IBD)	2/1038	56/7206	0.01960351204
ko01524	Platinum drug resistance	4/1038	76/7206	0.0202651698319
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1038	40/7206	0.0237213285731
ko00140	Steroid hormone biosynthesis	1/1038	41/7206	0.0238057870835
ko04668	TNF signaling pathway	9/1038	120/7206	0.0258825895307
ko05131	Shigellosis	5/1038	82/7206	0.0266798108619
ko03018	RNA degradation	5/1038	84/7206	0.0271238134181
ko05418	Fluid shear stress and atherosclerosis	15/1038	173/7206	0.0280918519189
ko04622	RIG-I-like receptor signaling pathway	3/1038	62/7206	0.0281553670678
ko04930	Type II diabetes mellitus	14/1038	54/7206	0.0293277556351
ko04371	Apelin signaling pathway	36/1038	177/7206	0.029503314986
ko05034	Alcoholism	46/1038	238/7206	0.0308908957043
ko04210	Apoptosis	16/1038	180/7206	0.0313245617585
ko04140	Autophagy - animal	14/1038	164/7206	0.0318126601832
ko04923	Regulation of lipolysis in adipocytes	18/1038	77/7206	0.0325362156341
ko00562	Inositol phosphate metabolism	20/1038	89/7206	0.0337642844062
ko00982	Drug metabolism - cytochrome P450	1/1038	37/7206	0.0351212379534
ko00630	Glyoxylate and dicarboxylate metabolism	1/1038	38/7206	0.0351558540175
ko05145	Toxoplasmosis	10/1038	126/7206	0.039531968891
ko00380	Tryptophan metabolism	2/1038	50/7206	0.0400595095488
ko04973	Carbohydrate digestion and absorption	11/1038	42/7206	0.0433946114479
ko04657	IL-17 signaling pathway	6/1038	87/7206	0.0450619245271
ko05133	Pertussis	6/1038	87/7206	0.0450619245271