ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 37/542 191/7206 5.97506589669e-08 ko05340 Primary immunodeficiency 12/542 30/7206 7.15148602543e-07 ko04146 Peroxisome 19/542 89/7206 2.53975287973e-05 ko04710 Circadian rhythm 12/542 43/7206 5.11834903427e-05 ko00120 Primary bile acid biosynthesis 8/542 20/7206 5.444222467e-05 ko04610 Complement and coagulation cascades 17/542 79/7206 6.05496971831e-05 ko05034 Alcoholism 4/542 238/7206 8.46878655548e-05 ko04137 Mitophagy - animal 17/542 82/7206 9.93020484297e-05 ko05150 Staphylococcus aureus infection 10/542 36/7206 0.000226157947245 ko04650 Natural killer cell mediated cytotoxicity 18/542 97/7206 0.0002758596104 ko03040 Spliceosome 1/542 145/7206 0.000321074749855 ko04380 Osteoclast differentiation 22/542 134/7206 0.000404104067623 ko03013 RNA transport 2/542 166/7206 0.00046712238001 ko05321 Inflammatory bowel disease (IBD) 12/542 56/7206 0.00075619565637 ko04640 Hematopoietic cell lineage 13/542 64/7206 0.000790849978211 ko03010 Ribosome 1/542 129/7206 0.00101711683422 ko04672 Intestinal immune network for IgA production 9/542 37/7206 0.00132993551642 ko02010 ABC transporters 9/542 39/7206 0.00197932769223 ko04110 Cell cycle 2/542 145/7206 0.00203676267122 ko00592 alpha-Linolenic acid metabolism 6/542 19/7206 0.00204669413557 ko00051 Fructose and mannose metabolism 9/542 42/7206 0.00340272199851 ko00950 Isoquinoline alkaloid biosynthesis 4/542 10/7206 0.00460767216872 ko00982 Drug metabolism - cytochrome P450 8/542 37/7206 0.00534293108661 ko04072 Phospholipase D signaling pathway 26/542 197/7206 0.00549840590406 ko05144 Malaria 9/542 45/7206 0.00552847366559 ko03015 mRNA surveillance pathway 1/542 93/7206 0.00945195745629 ko00830 Retinol metabolism 8/542 42/7206 0.0117327640861 ko04630 Jak-STAT signaling pathway 18/542 132/7206 0.0117537970368 ko00590 Arachidonic acid metabolism 9/542 52/7206 0.0143778048714 ko04659 Th17 cell differentiation 15/542 106/7206 0.0148206877049 ko04611 Platelet activation 21/542 163/7206 0.0149622282111 ko04012 ErbB signaling pathway 2/542 109/7206 0.0164615474416 ko04658 Th1 and Th2 cell differentiation 14/542 96/7206 0.0167468311057 ko00071 Fatty acid degradation 8/542 45/7206 0.0175862652937 ko05320 Autoimmune thyroid disease 6/542 29/7206 0.0188591986583 ko05230 Central carbon metabolism in cancer 12/542 81/7206 0.0189539608693 ko00564 Glycerophospholipid metabolism 14/542 99/7206 0.0193949462128 ko05323 Rheumatoid arthritis 13/542 89/7206 0.0226672878743 ko04136 Autophagy - other 6/542 31/7206 0.0257457558818 ko05140 Leishmaniasis 11/542 75/7206 0.0263857403787 ko04514 Cell adhesion molecules (CAMs) 17/542 130/7206 0.0267713148934 ko04670 Leukocyte transendothelial migration 19/542 151/7206 0.0271067775085 ko04070 Phosphatidylinositol signaling system 15/542 112/7206 0.0277525814329 ko04721 Synaptic vesicle cycle 1/542 80/7206 0.029769099742 ko05330 Allograft rejection 5/542 24/7206 0.0303801167428 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/542 4/7206 0.030594264326 ko04722 Neurotrophin signaling pathway 5/542 160/7206 0.0323271260425 ko00350 Tyrosine metabolism 6/542 33/7206 0.0341268905485 ko05310 Asthma 4/542 17/7206 0.0342914106767 ko00360 Phenylalanine metabolism 4/542 17/7206 0.0342914106767 ko00565 Ether lipid metabolism 7/542 42/7206 0.0353282477886 ko01040 Biosynthesis of unsaturated fatty acids 5/542 25/7206 0.0357058708177 ko05203 Viral carcinogenesis 12/542 277/7206 0.0365617853308 ko03320 PPAR signaling pathway 10/542 69/7206 0.0368778308818 ko05224 Breast cancer 6/542 174/7206 0.0401827806433 ko04922 Glucagon signaling pathway 16/542 128/7206 0.0406464987136 ko04612 Antigen processing and presentation 11/542 77/7206 0.0454032732001 ko00330 Arginine and proline metabolism 9/542 61/7206 0.0456488971722