ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	149/920	423/7206	6.7101008974e-35
ko04724	Glutamatergic synapse	81/920	152/7206	6.43487553094e-34
ko05033	Nicotine addiction	43/920	56/7206	5.49814254839e-28
ko05032	Morphine addiction	59/920	110/7206	4.03497901542e-25
ko04713	Circadian entrainment	65/920	136/7206	7.07400555745e-24
ko04727	GABAergic synapse	57/920	110/7206	2.64483653593e-23
ko04728	Dopaminergic synapse	72/920	185/7206	7.48162070153e-20
ko04723	Retrograde endocannabinoid signaling	66/920	175/7206	1.90619669464e-17
ko04725	Cholinergic synapse	61/920	160/7206	1.8065735674e-16
ko04024	cAMP signaling pathway	85/920	279/7206	2.11373146745e-15
ko04020	Calcium signaling pathway	80/920	265/7206	2.37157130326e-14
ko04744	Phototransduction	24/920	36/7206	7.3200947052e-14
ko04911	Insulin secretion	46/920	117/7206	2.76551182643e-13
ko04721	Synaptic vesicle cycle	36/920	80/7206	9.38546395678e-13
ko04742	Taste transduction	30/920	61/7206	4.44089019901e-12
ko05031	Amphetamine addiction	37/920	91/7206	1.8949636449e-11
ko04921	Oxytocin signaling pathway	61/920	209/7206	1.45575123732e-10
ko04720	Long-term potentiation	37/920	99/7206	3.44915882566e-10
ko04726	Serotonergic synapse	45/920	137/7206	6.10519083766e-10
ko04261	Adrenergic signaling in cardiomyocytes	59/920	205/7206	7.4063887794e-10
ko05030	Cocaine addiction	28/920	73/7206	2.55105130933e-08
ko05203	Viral carcinogenesis	10/920	277/7206	1.75011898948e-07
ko04970	Salivary secretion	31/920	95/7206	3.46538551321e-07
ko04925	Aldosterone synthesis and secretion	33/920	105/7206	3.91325325858e-07
ko03010	Ribosome	1/920	129/7206	7.21483121074e-07
ko03040	Spliceosome	2/920	145/7206	9.18130314313e-07
ko04070	Phosphatidylinositol signaling system	33/920	112/7206	2.20250674594e-06
ko04072	Phospholipase D signaling pathway	49/920	197/7206	2.34533661824e-06
ko04060	Cytokine-cytokine receptor interaction	6/920	191/7206	4.81895961988e-06
ko04110	Cell cycle	3/920	145/7206	6.89907008363e-06
ko04740	Olfactory transduction	25/920	80/7206	1.11834916902e-05
ko04010	MAPK signaling pathway	68/920	321/7206	1.58590984526e-05
ko05322	Systemic lupus erythematosus	4/920	151/7206	1.97351424257e-05
ko04621	NOD-like receptor signaling pathway	5/920	157/7206	4.99560842994e-05
ko05168	Herpes simplex infection	7/920	182/7206	6.41415079253e-05
ko05169	Epstein-Barr virus infection	9/920	206/7206	7.15442043286e-05
ko05164	Influenza A	6/920	167/7206	8.30814054578e-05
ko04514	Cell adhesion molecules (CAMs)	33/920	130/7206	8.44481649632e-05
ko04971	Gastric acid secretion	27/920	98/7206	8.4673443316e-05
ko04730	Long-term depression	23/920	78/7206	9.17077523788e-05
ko04022	cGMP-PKG signaling pathway	48/920	216/7206	0.000104960798835
ko04745	Phototransduction - fly	14/920	38/7206	0.000137373211674
ko04710	Circadian rhythm	15/920	43/7206	0.000162936269838
ko04972	Pancreatic secretion	28/920	111/7206	0.000279565123897
ko05014	Amyotrophic lateral sclerosis (ALS)	21/920	74/7206	0.000296132601501
ko03013	RNA transport	7/920	166/7206	0.000344101832615
ko04612	Antigen processing and presentation	1/920	77/7206	0.000482290801841
ko04260	Cardiac muscle contraction	25/920	98/7206	0.000598602318139
ko05162	Measles	4/920	120/7206	0.000755352378724
ko04966	Collecting duct acid secretion	10/920	26/7206	0.000843530124509
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	21/920	79/7206	0.000923025180582
ko05205	Proteoglycans in cancer	18/920	271/7206	0.00149330124882
ko04064	NF-kappa B signaling pathway	3/920	96/7206	0.00183496782957
ko00562	Inositol phosphate metabolism	22/920	89/7206	0.00194685376414
ko05110	Vibrio cholerae infection	17/920	63/7206	0.00196800965144
ko04964	Proximal tubule bicarbonate reclamation	10/920	29/7206	0.00222173038215
ko04930	Type II diabetes mellitus	15/920	54/7206	0.00300953650269
ko04915	Estrogen signaling pathway	29/920	131/7206	0.00323755429336
ko04610	Complement and coagulation cascades	2/920	79/7206	0.00328392402748
ko03008	Ribosome biogenesis in eukaryotes	2/920	79/7206	0.00328392402748
ko04141	Protein processing in endoplasmic reticulum	11/920	184/7206	0.00342599955771
ko04330	Notch signaling pathway	1/920	62/7206	0.00353367358285
ko04750	Inflammatory mediator regulation of TRP channels	27/920	122/7206	0.00365424533778
ko05161	Hepatitis B	10/920	173/7206	0.00367534034341
ko05414	Dilated cardiomyopathy	25/920	112/7206	0.00408300428638
ko04350	TGF-beta signaling pathway	4/920	103/7206	0.00416109443361
ko04014	Ras signaling pathway	52/920	279/7206	0.00437401656931
ko05140	Leishmaniasis	2/920	75/7206	0.0046660546256
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/920	14/7206	0.0051459153509
ko04510	Focal adhesion	17/920	240/7206	0.00567541450575
ko05215	Prostate cancer	5/920	111/7206	0.00590798959975
ko04922	Glucagon signaling pathway	27/920	128/7206	0.00713245836108
ko05200	Pathways in cancer	44/920	492/7206	0.00770130333885
ko04924	Renin secretion	20/920	86/7206	0.00814411685291
ko03320	PPAR signaling pathway	2/920	69/7206	0.00984468285774
ko05131	Shigellosis	3/920	82/7206	0.0111745873142
ko00590	Arachidonic acid metabolism	1/920	52/7206	0.0114677400956
ko04540	Gap junction	26/920	128/7206	0.0152801335063
ko04630	Jak-STAT signaling pathway	8/920	132/7206	0.0172152029773
ko00240	Pyrimidine metabolism	6/920	110/7206	0.0200408856179
ko04626	Plant-pathogen interaction	6/920	18/7206	0.020317291581
ko04360	Axon guidance	42/920	233/7206	0.0211086013188
ko04657	IL-17 signaling pathway	4/920	87/7206	0.0219245262068
ko04210	Apoptosis	13/920	180/7206	0.0230979040448
ko00071	Fatty acid degradation	1/920	45/7206	0.0250074128543
ko03420	Nucleotide excision repair	1/920	46/7206	0.0250209554108
ko05166	HTLV-I infection	25/920	292/7206	0.0252719439358
ko05231	Choline metabolism in cancer	26/920	134/7206	0.025750084571
ko05219	Bladder cancer	1/920	48/7206	0.0264309843498
ko04120	Ubiquitin mediated proteolysis	9/920	138/7206	0.0274849622324
ko04976	Bile secretion	17/920	80/7206	0.0281670691892
ko05034	Alcoholism	42/920	238/7206	0.0291189587083
ko00230	Purine metabolism	35/920	194/7206	0.0292096042009
ko04217	Necroptosis	13/920	178/7206	0.0297839698178
ko04214	Apoptosis - fly	3/920	72/7206	0.0307283130719
ko04550	Signaling pathways regulating pluripotency of stem cells	12/920	165/7206	0.032898558938
ko00680	Methane metabolism	9/920	34/7206	0.032941220656
ko00010	Glycolysis / Gluconeogenesis	16/920	74/7206	0.0332487150282
ko04960	Aldosterone-regulated sodium reabsorption	10/920	41/7206	0.0337466326837
ko05410	Hypertrophic cardiomyopathy (HCM)	20/920	100/7206	0.0345042312157
ko05418	Fluid shear stress and atherosclerosis	13/920	173/7206	0.0371949931941
ko04146	Peroxisome	5/920	89/7206	0.0378462107791
ko05222	Small cell lung cancer	5/920	89/7206	0.0378462107791
ko04923	Regulation of lipolysis in adipocytes	16/920	77/7206	0.0396691140519
ko00480	Glutathione metabolism	2/920	55/7206	0.0407208842613
ko05416	Viral myocarditis	2/920	55/7206	0.0407208842613
ko05321	Inflammatory bowel disease (IBD)	2/920	56/7206	0.0414339412183
ko05217	Basal cell carcinoma	3/920	68/7206	0.0420305469124
ko05202	Transcriptional misregulation in cancer	15/920	188/7206	0.0459782964201
ko05132	Salmonella infection	6/920	98/7206	0.046921189139
ko04810	Regulation of actin cytoskeleton	23/920	264/7206	0.0478944382085
ko05016	Huntington's disease	18/920	215/7206	0.0487556000796