ko pathway ratio_in_study ratio_in_pop p_value ko04710 Circadian rhythm 16/691 43/7206 9.59595409344e-07 ko04744 Phototransduction 14/691 36/7206 2.49385056357e-06 ko04020 Calcium signaling pathway 49/691 265/7206 5.53972022257e-06 ko04713 Circadian entrainment 30/691 136/7206 1.05985413135e-05 ko04080 Neuroactive ligand-receptor interaction 68/691 423/7206 1.72652755544e-05 ko03010 Ribosome 1/691 129/7206 5.58401322602e-05 ko05322 Systemic lupus erythematosus 2/691 151/7206 6.24520453836e-05 ko03013 RNA transport 3/691 166/7206 8.50926220956e-05 ko03040 Spliceosome 2/691 145/7206 8.93738167557e-05 ko04921 Oxytocin signaling pathway 37/691 209/7206 0.000190843057055 ko04922 Glucagon signaling pathway 26/691 128/7206 0.000194073500737 ko04724 Glutamatergic synapse 29/691 152/7206 0.000246954895427 ko00120 Primary bile acid biosynthesis 8/691 20/7206 0.000303543527156 ko04925 Aldosterone synthesis and secretion 22/691 105/7206 0.000343658675442 ko00830 Retinol metabolism 12/691 42/7206 0.000406384840353 ko00360 Phenylalanine metabolism 7/691 17/7206 0.000595496536144 ko04974 Protein digestion and absorption 20/691 96/7206 0.000697401013278 ko00350 Tyrosine metabolism 10/691 33/7206 0.0007372451709 ko05032 Morphine addiction 22/691 110/7206 0.000811204151266 ko04972 Pancreatic secretion 22/691 111/7206 0.000881892520351 ko04144 Endocytosis 16/691 342/7206 0.000913639110548 ko04740 Olfactory transduction 17/691 80/7206 0.00156508277145 ko00230 Purine metabolism 32/691 194/7206 0.00188926920319 ko04022 cGMP-PKG signaling pathway 35/691 216/7206 0.00203896355256 ko04745 Phototransduction - fly 10/691 38/7206 0.00242412915213 ko04110 Cell cycle 4/691 145/7206 0.00242912642052 ko04726 Serotonergic synapse 24/691 137/7206 0.00309943750973 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/691 4/7206 0.00326153702265 ko04270 Vascular smooth muscle contraction 26/691 154/7206 0.00352128055872 ko04390 Hippo signaling pathway 7/691 188/7206 0.00356530951587 ko04976 Bile secretion 16/691 80/7206 0.00364314043914 ko05224 Breast cancer 6/691 174/7206 0.0036992988094 ko00680 Methane metabolism 9/691 34/7206 0.00379043276179 ko04725 Cholinergic synapse 27/691 160/7206 0.00384109497831 ko00140 Steroid hormone biosynthesis 10/691 41/7206 0.00441903103633 ko00010 Glycolysis / Gluconeogenesis 15/691 74/7206 0.0044281944697 ko04727 GABAergic synapse 20/691 110/7206 0.00475889339013 ko00983 Drug metabolism - other enzymes 10/691 42/7206 0.00531406203825 ko00051 Fructose and mannose metabolism 10/691 42/7206 0.00531406203825 ko04711 Circadian rhythm - fly 5/691 13/7206 0.00534526536335 ko04070 Phosphatidylinositol signaling system 20/691 112/7206 0.00543296728917 ko05130 Pathogenic Escherichia coli infection 1/691 77/7206 0.00599829285804 ko05203 Viral carcinogenesis 14/691 277/7206 0.00662328834799 ko00592 alpha-Linolenic acid metabolism 6/691 19/7206 0.00693310206446 ko04750 Inflammatory mediator regulation of TRP channels 21/691 122/7206 0.00755647180512 ko04371 Apelin signaling pathway 28/691 177/7206 0.0089938166426 ko04966 Collecting duct acid secretion 7/691 26/7206 0.00937978371758 ko02010 ABC transporters 9/691 39/7206 0.00993306063838 ko00950 Isoquinoline alkaloid biosynthesis 4/691 10/7206 0.0109881613268 ko04068 FoxO signaling pathway 26/691 167/7206 0.0112947863644 ko04970 Salivary secretion 17/691 95/7206 0.0122886783133 ko04120 Ubiquitin mediated proteolysis 5/691 138/7206 0.0123926844436 ko00362 Benzoate degradation 3/691 6/7206 0.0140713963147 ko04971 Gastric acid secretion 17/691 98/7206 0.0143462894978 ko04550 Signaling pathways regulating pluripotency of stem cells 7/691 165/7206 0.0153654401519 ko05210 Colorectal cancer 2/691 86/7206 0.0155000611476 ko04975 Fat digestion and absorption 8/691 35/7206 0.0156119742094 ko04350 TGF-beta signaling pathway 3/691 103/7206 0.0169046336285 ko05217 Basal cell carcinoma 1/691 68/7206 0.0198575595783 ko05212 Pancreatic cancer 2/691 83/7206 0.0223802112535 ko01230 Biosynthesis of amino acids 15/691 85/7206 0.0234907634882 ko05100 Bacterial invasion of epithelial cells 3/691 99/7206 0.023646751231 ko04213 Longevity regulating pathway - multiple species 15/691 86/7206 0.0243099936305 ko00380 Tryptophan metabolism 10/691 50/7206 0.0248477534153 ko05031 Amphetamine addiction 15/691 91/7206 0.0311294631413 ko04930 Type II diabetes mellitus 10/691 54/7206 0.0347316117211 ko04720 Long-term potentiation 16/691 99/7206 0.0367686456299 ko00620 Pyruvate metabolism 9/691 46/7206 0.0378534635078 ko04024 cAMP signaling pathway 37/691 279/7206 0.0379243051736 ko04911 Insulin secretion 18/691 117/7206 0.0388432658474 ko00710 Carbon fixation in photosynthetic organisms 6/691 27/7206 0.0392051312509 ko04924 Renin secretion 14/691 86/7206 0.0417802068629 ko04071 Sphingolipid signaling pathway 8/691 162/7206 0.0420565229396 ko04520 Adherens junction 4/691 103/7206 0.043195310181 ko04919 Thyroid hormone signaling pathway 21/691 143/7206 0.043788864155 ko04111 Cell cycle - yeast 3/691 90/7206 0.0451148713108 ko04391 Hippo signaling pathway - fly 3/691 90/7206 0.0451148713108 ko00643 Styrene degradation 2/691 4/7206 0.0483250662165 ko00561 Glycerolipid metabolism 11/691 63/7206 0.0486038120713