ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 91/566 423/7206 4.27593099505e-20 ko04724 Glutamatergic synapse 50/566 152/7206 1.76838652306e-19 ko04728 Dopaminergic synapse 53/566 185/7206 1.42468155959e-17 ko04725 Cholinergic synapse 47/566 160/7206 3.63724131048e-16 ko04721 Synaptic vesicle cycle 32/566 80/7206 1.15531337764e-15 ko04713 Circadian entrainment 42/566 136/7206 2.04151869618e-15 ko05032 Morphine addiction 36/566 110/7206 2.97917678685e-14 ko04727 GABAergic synapse 35/566 110/7206 1.78296368052e-13 ko04911 Insulin secretion 36/566 117/7206 2.51276528981e-13 ko04726 Serotonergic synapse 38/566 137/7206 2.00490172799e-12 ko05031 Amphetamine addiction 29/566 91/7206 2.13167997627e-11 ko05033 Nicotine addiction 22/566 56/7206 5.60123618941e-11 ko04723 Retrograde endocannabinoid signaling 41/566 175/7206 9.7207139677e-11 ko04921 Oxytocin signaling pathway 45/566 209/7206 2.33197132572e-10 ko04024 cAMP signaling pathway 53/566 279/7206 8.23706849359e-10 ko04720 Long-term potentiation 27/566 99/7206 5.13073394845e-09 ko04020 Calcium signaling pathway 47/566 265/7206 7.41829708247e-08 ko04261 Adrenergic signaling in cardiomyocytes 39/566 205/7206 1.80287230344e-07 ko04970 Salivary secretion 24/566 95/7206 1.81376662941e-07 ko05030 Cocaine addiction 20/566 73/7206 4.71995285294e-07 ko04925 Aldosterone synthesis and secretion 24/566 105/7206 1.31520833899e-06 ko04966 Collecting duct acid secretion 11/566 26/7206 1.6554916126e-06 ko05110 Vibrio cholerae infection 17/566 63/7206 4.31470821285e-06 ko04022 cGMP-PKG signaling pathway 36/566 216/7206 1.38879411174e-05 ko04010 MAPK signaling pathway 47/566 321/7206 2.63824546051e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 17/566 74/7206 4.32151090647e-05 ko04971 Gastric acid secretion 20/566 98/7206 5.81548603191e-05 ko04730 Long-term depression 17/566 78/7206 8.78396928815e-05 ko04360 Axon guidance 36/566 233/7206 9.13904682847e-05 ko04745 Phototransduction - fly 11/566 38/7206 0.000107882299554 ko04972 Pancreatic secretion 21/566 111/7206 0.000121528033829 ko04540 Gap junction 23/566 128/7206 0.000158784632026 ko05120 Epithelial cell signaling in Helicobacter pylori infection 18/566 92/7206 0.000236858905531 ko04922 Glucagon signaling pathway 22/566 128/7206 0.00038282729042 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/566 59/7206 0.00052462839092 ko05322 Systemic lupus erythematosus 2/566 151/7206 0.000642421412933 ko04930 Type II diabetes mellitus 12/566 54/7206 0.000787171565345 ko03040 Spliceosome 2/566 145/7206 0.000928514188915 ko05010 Alzheimer's disease 29/566 202/7206 0.00129042456608 ko04014 Ras signaling pathway 37/566 279/7206 0.00136755652458 ko04750 Inflammatory mediator regulation of TRP channels 20/566 122/7206 0.00169846727138 ko05168 Herpes simplex infection 4/566 182/7206 0.00186576946873 ko04626 Plant-pathogen interaction 6/566 18/7206 0.00187130953395 ko04924 Renin secretion 15/566 86/7206 0.00342556901071 ko04114 Oocyte meiosis 21/566 139/7206 0.00350698135614 ko04070 Phosphatidylinositol signaling system 18/566 112/7206 0.00365681377156 ko04371 Apelin signaling pathway 25/566 177/7206 0.00409234070366 ko04514 Cell adhesion molecules (CAMs) 20/566 130/7206 0.00429231970178 ko04915 Estrogen signaling pathway 20/566 131/7206 0.0044370482904 ko05034 Alcoholism 31/566 238/7206 0.00456096128475 ko03013 RNA transport 4/566 166/7206 0.0050203096092 ko04744 Phototransduction 8/566 36/7206 0.00581812199502 ko04918 Thyroid hormone synthesis 14/566 86/7206 0.00753435213572 ko04120 Ubiquitin mediated proteolysis 3/566 138/7206 0.00940297780794 ko04912 GnRH signaling pathway 18/566 122/7206 0.00946699515693 ko04740 Olfactory transduction 13/566 80/7206 0.0103229990661 ko04916 Melanogenesis 20/566 142/7206 0.010492421265 ko00240 Pyrimidine metabolism 2/566 110/7206 0.0115076674761 ko04260 Cardiac muscle contraction 15/566 98/7206 0.0120043157287 ko04960 Aldosterone-regulated sodium reabsorption 8/566 41/7206 0.0129974013068 ko05167 Kaposi's sarcoma-associated herpesvirus infection 25/566 191/7206 0.013115287228 ko00010 Glycolysis / Gluconeogenesis 12/566 74/7206 0.014235178114 ko05323 Rheumatoid arthritis 14/566 89/7206 0.0147722005574 ko00680 Methane metabolism 7/566 34/7206 0.0147786401268 ko04015 Rap1 signaling pathway 33/566 278/7206 0.0163010667558 ko04270 Vascular smooth muscle contraction 20/566 154/7206 0.0224841800434 ko04062 Chemokine signaling pathway 25/566 201/7206 0.0225306524479 ko04964 Proximal tubule bicarbonate reclamation 6/566 29/7206 0.0228856803538 ko05162 Measles 3/566 120/7206 0.0245523310048 ko04742 Taste transduction 10/566 61/7206 0.0260591585399 ko00190 Oxidative phosphorylation 17/566 127/7206 0.0286011199103 ko04612 Antigen processing and presentation 1/566 77/7206 0.0297370538508 ko04072 Phospholipase D signaling pathway 24/566 197/7206 0.0304232348782 ko04722 Neurotrophin signaling pathway 20/566 160/7206 0.0360295509974 ko04071 Sphingolipid signaling pathway 20/566 162/7206 0.0380544823335 ko04145 Phagosome 20/566 162/7206 0.0380544823335 ko05164 Influenza A 6/566 167/7206 0.0400349973301 ko04962 Vasopressin-regulated water reabsorption 9/566 58/7206 0.0441461435894 ko00310 Lysine degradation 1/566 73/7206 0.044177206822 ko04146 Peroxisome 2/566 89/7206 0.0458108214633