ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 45/583 191/7206 2.55236631881e-11 ko00120 Primary bile acid biosynthesis 11/583 20/7206 7.58232450646e-08 ko04610 Complement and coagulation cascades 22/583 79/7206 1.5446167171e-07 ko05340 Primary immunodeficiency 13/583 30/7206 1.84190330287e-07 ko04621 NOD-like receptor signaling pathway 32/583 157/7206 7.41300506107e-07 ko04380 Osteoclast differentiation 28/583 134/7206 2.19418390696e-06 ko05164 Influenza A 31/583 167/7206 9.27183310435e-06 ko05150 Staphylococcus aureus infection 12/583 36/7206 1.43944416165e-05 ko04137 Mitophagy - animal 19/583 82/7206 2.06642600599e-05 ko04650 Natural killer cell mediated cytotoxicity 21/583 97/7206 2.32742767167e-05 ko05321 Inflammatory bowel disease (IBD) 15/583 56/7206 2.48006867667e-05 ko00140 Steroid hormone biosynthesis 12/583 41/7206 6.23530549342e-05 ko04146 Peroxisome 19/583 89/7206 6.93936301601e-05 ko04672 Intestinal immune network for IgA production 11/583 37/7206 0.000107802254467 ko04217 Necroptosis 30/583 178/7206 0.000117190316173 ko05034 Alcoholism 5/583 238/7206 0.00014019669853 ko03040 Spliceosome 1/583 145/7206 0.000144209492383 ko05145 Toxoplasmosis 23/583 126/7206 0.00018397270815 ko00590 Arachidonic acid metabolism 13/583 52/7206 0.000184753082965 ko00350 Tyrosine metabolism 10/583 33/7206 0.000186021790625 ko00051 Fructose and mannose metabolism 11/583 42/7206 0.00037179757006 ko05167 Kaposi's sarcoma-associated herpesvirus infection 30/583 191/7206 0.000377147066319 ko04659 Th17 cell differentiation 20/583 106/7206 0.000392897498139 ko03010 Ribosome 1/583 129/7206 0.000446189615644 ko05162 Measles 21/583 120/7206 0.00059469511906 ko03013 RNA transport 3/583 166/7206 0.000803752813021 ko05140 Leishmaniasis 15/583 75/7206 0.000823087666928 ko04064 NF-kappa B signaling pathway 18/583 96/7206 0.000872831458399 ko04110 Cell cycle 2/583 145/7206 0.000962062027365 ko04630 Jak-STAT signaling pathway 22/583 132/7206 0.000995743210345 ko04620 Toll-like receptor signaling pathway 18/583 100/7206 0.00117189575807 ko04310 Wnt signaling pathway 4/583 181/7206 0.00131194783738 ko00360 Phenylalanine metabolism 6/583 17/7206 0.00155871828527 ko04710 Circadian rhythm 10/583 43/7206 0.00184252406428 ko05133 Pertussis 16/583 87/7206 0.00206116277834 ko05168 Herpes simplex infection 27/583 182/7206 0.00209323564959 ko04660 T cell receptor signaling pathway 20/583 124/7206 0.00242862051995 ko05152 Tuberculosis 27/583 187/7206 0.0026154351949 ko05224 Breast cancer 4/583 174/7206 0.00268320459628 ko04390 Hippo signaling pathway 5/583 188/7206 0.00270578900662 ko04540 Gap junction 2/583 128/7206 0.00276354518052 ko00592 alpha-Linolenic acid metabolism 6/583 19/7206 0.00297158089075 ko00330 Arginine and proline metabolism 12/583 61/7206 0.00308604758381 ko03320 PPAR signaling pathway 13/583 69/7206 0.003143691594 ko00561 Glycerolipid metabolism 12/583 63/7206 0.00407527417694 ko04612 Antigen processing and presentation 14/583 77/7206 0.00458231628714 ko04640 Hematopoietic cell lineage 12/583 64/7206 0.00465745923288 ko05323 Rheumatoid arthritis 15/583 89/7206 0.00532165825133 ko00830 Retinol metabolism 9/583 42/7206 0.00552370359015 ko00950 Isoquinoline alkaloid biosynthesis 4/583 10/7206 0.00599836743553 ko03015 mRNA surveillance pathway 1/583 93/7206 0.00639717811307 ko05160 Hepatitis C 22/583 153/7206 0.00672487818926 ko04658 Th1 and Th2 cell differentiation 16/583 96/7206 0.00683284974918 ko04723 Retrograde endocannabinoid signaling 5/583 175/7206 0.00705115103398 ko05320 Autoimmune thyroid disease 7/583 29/7206 0.00708282067721 ko00982 Drug metabolism - cytochrome P450 8/583 37/7206 0.00824849706748 ko04724 Glutamatergic synapse 4/583 152/7206 0.00963672978547 ko04111 Cell cycle - yeast 1/583 90/7206 0.00967483591762 ko05330 Allograft rejection 6/583 24/7206 0.0104183021296 ko05032 Morphine addiction 2/583 110/7206 0.0119572144458 ko01040 Biosynthesis of unsaturated fatty acids 6/583 25/7206 0.0127940113291 ko04670 Leukocyte transendothelial migration 21/583 151/7206 0.0144982550518 ko00564 Glycerophospholipid metabolism 15/583 99/7206 0.0149974571947 ko04662 B cell receptor signaling pathway 14/583 88/7206 0.0155643588867 ko04062 Chemokine signaling pathway 26/583 201/7206 0.0171670615507 ko00380 Tryptophan metabolism 9/583 50/7206 0.0174356102296 ko00983 Drug metabolism - other enzymes 8/583 42/7206 0.0176642524961 ko00565 Ether lipid metabolism 8/583 42/7206 0.0176642524961 ko04114 Oocyte meiosis 4/583 139/7206 0.017773581552 ko04530 Tight junction 9/583 228/7206 0.0182281535837 ko04916 Melanogenesis 4/583 142/7206 0.0182403680384 ko00100 Steroid biosynthesis 5/583 21/7206 0.02334712135 ko04911 Insulin secretion 3/583 117/7206 0.0245281915712 ko04713 Circadian entrainment 4/583 136/7206 0.0246391297376 ko04668 TNF signaling pathway 17/583 120/7206 0.0258439994995 ko05144 Malaria 8/583 45/7206 0.0260868910855 ko04728 Dopaminergic synapse 7/583 185/7206 0.0278775311861 ko04611 Platelet activation 21/583 163/7206 0.0288887419684 ko04622 RIG-I-like receptor signaling pathway 10/583 62/7206 0.0311296297813 ko04727 GABAergic synapse 3/583 110/7206 0.0334538278343 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/583 4/7206 0.0351223849015 ko00643 Styrene degradation 2/583 4/7206 0.0351223849015 ko04136 Autophagy - other 6/583 31/7206 0.0352568469398 ko04010 MAPK signaling pathway 16/583 321/7206 0.0358448817588 ko05206 MicroRNAs in cancer 7/583 177/7206 0.0364013695712 ko00980 Metabolism of xenobiotics by cytochrome P450 7/583 40/7206 0.03920612819 ko05217 Basal cell carcinoma 1/583 68/7206 0.0417025165762 ko04068 FoxO signaling pathway 21/583 167/7206 0.0426555339874 ko05310 Asthma 4/583 17/7206 0.0432325223784 ko04623 Cytosolic DNA-sensing pathway 7/583 41/7206 0.044117320202