ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 85/889 152/7206 6.53068309906e-39 ko05033 Nicotine addiction 46/889 56/7206 5.79716828698e-33 ko05032 Morphine addiction 66/889 110/7206 6.40338731005e-33 ko04080 Neuroactive ligand-receptor interaction 141/889 423/7206 1.06361282981e-31 ko04727 GABAergic synapse 64/889 110/7206 7.73898474477e-31 ko04713 Circadian entrainment 67/889 136/7206 1.91452310266e-26 ko04728 Dopaminergic synapse 78/889 185/7206 4.81988625213e-25 ko04723 Retrograde endocannabinoid signaling 74/889 175/7206 6.81365570076e-24 ko04744 Phototransduction 27/889 36/7206 6.36022217207e-18 ko04725 Cholinergic synapse 62/889 160/7206 7.07858543878e-18 ko04020 Calcium signaling pathway 80/889 265/7206 3.13959435345e-15 ko04721 Synaptic vesicle cycle 38/889 80/7206 8.0190342239e-15 ko04911 Insulin secretion 47/889 117/7206 1.55873205057e-14 ko04726 Serotonergic synapse 51/889 137/7206 4.41284355207e-14 ko05031 Amphetamine addiction 39/889 91/7206 2.34851488987e-13 ko04921 Oxytocin signaling pathway 63/889 209/7206 3.8938960645e-12 ko04024 cAMP signaling pathway 76/889 279/7206 5.72289052273e-12 ko04720 Long-term potentiation 38/889 99/7206 2.78863556561e-11 ko04261 Adrenergic signaling in cardiomyocytes 58/889 205/7206 4.2577141216e-10 ko04742 Taste transduction 27/889 61/7206 4.93801690722e-10 ko05030 Cocaine addiction 29/889 73/7206 2.49683605175e-09 ko04970 Salivary secretion 34/889 95/7206 2.71717891435e-09 ko04925 Aldosterone synthesis and secretion 36/889 105/7206 3.55132291433e-09 ko04010 MAPK signaling pathway 72/889 321/7206 2.14317124514e-07 ko04070 Phosphatidylinositol signaling system 34/889 112/7206 2.87563785945e-07 ko04740 Olfactory transduction 27/889 80/7206 4.6770602764e-07 ko05203 Viral carcinogenesis 11/889 277/7206 1.53151778347e-06 ko03040 Spliceosome 2/889 145/7206 2.26271052507e-06 ko04072 Phospholipase D signaling pathway 47/889 197/7206 5.01141626203e-06 ko04972 Pancreatic secretion 31/889 111/7206 7.14945251042e-06 ko04022 cGMP-PKG signaling pathway 50/889 216/7206 7.33636912382e-06 ko04060 Cytokine-cytokine receptor interaction 6/889 191/7206 1.02323888974e-05 ko04730 Long-term depression 24/889 78/7206 1.24660740239e-05 ko04971 Gastric acid secretion 28/889 98/7206 1.39668950699e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 23/889 74/7206 1.56856568842e-05 ko04745 Phototransduction - fly 15/889 38/7206 2.04196067781e-05 ko04110 Cell cycle 4/889 145/7206 6.13455632932e-05 ko04260 Cardiac muscle contraction 26/889 98/7206 0.00012950787737 ko05322 Systemic lupus erythematosus 5/889 151/7206 0.000147712019912 ko03013 RNA transport 6/889 166/7206 0.000170086043619 ko05162 Measles 3/889 120/7206 0.000212679898023 ko05169 Epstein-Barr virus infection 10/889 206/7206 0.000350402423551 ko05168 Herpes simplex infection 8/889 182/7206 0.000351093615719 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 21/889 79/7206 0.000454936679496 ko05205 Proteoglycans in cancer 16/889 271/7206 0.000467611542784 ko05164 Influenza A 7/889 167/7206 0.000475999664924 ko04915 Estrogen signaling pathway 30/889 131/7206 0.000662434273081 ko04810 Regulation of actin cytoskeleton 16/889 264/7206 0.00080586930991 ko04141 Protein processing in endoplasmic reticulum 9/889 184/7206 0.000893517017465 ko04350 TGF-beta signaling pathway 3/889 103/7206 0.00131404703578 ko04550 Signaling pathways regulating pluripotency of stem cells 8/889 165/7206 0.00167946647359 ko05034 Alcoholism 46/889 238/7206 0.0017469628596 ko02010 ABC transporters 12/889 39/7206 0.00187418451109 ko05231 Choline metabolism in cancer 29/889 134/7206 0.00206442928311 ko04924 Renin secretion 21/889 86/7206 0.00240048649185 ko04540 Gap junction 28/889 128/7206 0.00246888623892 ko04514 Cell adhesion molecules (CAMs) 28/889 130/7206 0.00275256063312 ko04966 Collecting duct acid secretion 9/889 26/7206 0.00280902846386 ko00562 Inositol phosphate metabolism 21/889 89/7206 0.00294108848048 ko04621 NOD-like receptor signaling pathway 8/889 157/7206 0.00306424469257 ko05414 Dilated cardiomyopathy 25/889 112/7206 0.00324786153484 ko04640 Hematopoietic cell lineage 1/889 64/7206 0.00360411535558 ko04014 Ras signaling pathway 51/889 279/7206 0.00379015186129 ko04918 Thyroid hormone synthesis 20/889 86/7206 0.00435942457196 ko04710 Circadian rhythm 12/889 43/7206 0.00461455006069 ko05202 Transcriptional misregulation in cancer 11/889 188/7206 0.00464732675247 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/889 59/7206 0.00475530757576 ko03008 Ribosome biogenesis in eukaryotes 2/889 79/7206 0.00496085500868 ko04510 Focal adhesion 16/889 240/7206 0.0049875212383 ko04932 Non-alcoholic fatty liver disease (NAFLD) 11/889 182/7206 0.00605244770645 ko04964 Proximal tubule bicarbonate reclamation 9/889 29/7206 0.00640360362212 ko04371 Apelin signaling pathway 34/889 177/7206 0.00746454325281 ko05215 Prostate cancer 5/889 111/7206 0.00824102017451 ko04630 Jak-STAT signaling pathway 7/889 132/7206 0.0105437280853 ko04140 Autophagy - animal 10/889 164/7206 0.0112801185435 ko04750 Inflammatory mediator regulation of TRP channels 25/889 122/7206 0.0114820247369 ko00520 Amino sugar and nucleotide sugar metabolism 1/889 55/7206 0.011831977244 ko00480 Glutathione metabolism 1/889 55/7206 0.011831977244 ko05217 Basal cell carcinoma 2/889 68/7206 0.0143735475664 ko03320 PPAR signaling pathway 2/889 69/7206 0.014823937809 ko00590 Arachidonic acid metabolism 1/889 52/7206 0.0175844077187 ko05166 HTLV-I infection 23/889 292/7206 0.0177767998221 ko04930 Type II diabetes mellitus 13/889 54/7206 0.0192055483965 ko05140 Leishmaniasis 3/889 75/7206 0.0213932070708 ko04657 IL-17 signaling pathway 4/889 87/7206 0.021511907637 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/889 14/7206 0.021741615811 ko04976 Bile secretion 17/889 80/7206 0.0242074871859 ko05219 Bladder cancer 1/889 48/7206 0.0254894846229 ko04360 Axon guidance 40/889 233/7206 0.02590681958 ko05224 Breast cancer 12/889 174/7206 0.0260330932143 ko00240 Pyrimidine metabolism 6/889 110/7206 0.027087080785 ko04064 NF-kappa B signaling pathway 5/889 96/7206 0.0283514667932 ko04960 Aldosterone-regulated sodium reabsorption 10/889 41/7206 0.028767076738 ko04214 Apoptosis - fly 3/889 72/7206 0.0298916417281 ko04330 Notch signaling pathway 2/889 62/7206 0.0300004025327 ko00310 Lysine degradation 3/889 73/7206 0.0301356361915 ko05410 Hypertrophic cardiomyopathy (HCM) 20/889 100/7206 0.0301995924204 ko05110 Vibrio cholerae infection 14/889 63/7206 0.0311371087839 ko04973 Carbohydrate digestion and absorption 10/889 42/7206 0.0324072648405 ko00230 Purine metabolism 34/889 194/7206 0.034584764521 ko04120 Ubiquitin mediated proteolysis 9/889 138/7206 0.0357265958658 ko04912 GnRH signaling pathway 23/889 122/7206 0.0360388145344 ko03022 Basal transcription factors 1/889 44/7206 0.0371718586653 ko04217 Necroptosis 13/889 178/7206 0.0374504858706 ko04062 Chemokine signaling pathway 35/889 201/7206 0.0378095527336 ko03420 Nucleotide excision repair 1/889 46/7206 0.0387561993356 ko05200 Pathways in cancer 46/889 492/7206 0.0391413432766 ko05145 Toxoplasmosis 8/889 126/7206 0.0394866978594 ko04922 Glucagon signaling pathway 24/889 128/7206 0.0403777180544 ko05131 Shigellosis 4/889 82/7206 0.0408307496218 ko04137 Mitophagy - animal 4/889 82/7206 0.0408307496218 ko05321 Inflammatory bowel disease (IBD) 2/889 56/7206 0.04100036095 ko04068 FoxO signaling pathway 12/889 167/7206 0.0421893248589 ko05016 Huntington's disease 17/889 215/7206 0.0451341218634