ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	199/1231	423/7206	1.1194181207e-49
ko04724	Glutamatergic synapse	90/1231	152/7206	3.20314730045e-32
ko05033	Nicotine addiction	47/1231	56/7206	6.28459229553e-28
ko05032	Morphine addiction	69/1231	110/7206	4.6456691649e-27
ko04713	Circadian entrainment	77/1231	136/7206	6.50692856185e-26
ko04727	GABAergic synapse	67/1231	110/7206	3.17218426874e-25
ko04725	Cholinergic synapse	81/1231	160/7206	6.87847665511e-23
ko04721	Synaptic vesicle cycle	52/1231	80/7206	1.03791507e-21
ko04728	Dopaminergic synapse	84/1231	185/7206	9.10835009996e-20
ko04723	Retrograde endocannabinoid signaling	79/1231	175/7206	1.8269708748e-18
ko04020	Calcium signaling pathway	104/1231	265/7206	2.0493338106e-18
ko04024	cAMP signaling pathway	106/1231	279/7206	1.75947225361e-17
ko04911	Insulin secretion	58/1231	117/7206	3.65842111931e-16
ko04726	Serotonergic synapse	62/1231	137/7206	8.40214186434e-15
ko04921	Oxytocin signaling pathway	82/1231	209/7206	1.49197425744e-14
ko04742	Taste transduction	37/1231	61/7206	2.17671683663e-14
ko04970	Salivary secretion	45/1231	95/7206	6.07287805983e-12
ko04261	Adrenergic signaling in cardiomyocytes	74/1231	205/7206	4.11010756858e-11
ko03040	Spliceosome	1/1231	145/7206	7.18106990502e-11
ko04720	Long-term potentiation	44/1231	99/7206	1.47203419377e-10
ko05031	Amphetamine addiction	41/1231	91/7206	3.74685972844e-10
ko04744	Phototransduction	23/1231	36/7206	4.44015501335e-10
ko03010	Ribosome	1/1231	129/7206	1.58985636202e-09
ko04925	Aldosterone synthesis and secretion	42/1231	105/7206	2.06910445873e-08
ko04022	cGMP-PKG signaling pathway	70/1231	216/7206	2.1310929115e-08
ko04971	Gastric acid secretion	39/1231	98/7206	7.87182874889e-08
ko04360	Axon guidance	71/1231	233/7206	3.10444366818e-07
ko03013	RNA transport	7/1231	166/7206	5.70076017681e-07
ko05322	Systemic lupus erythematosus	6/1231	151/7206	9.78783684831e-07
ko05168	Herpes simplex infection	9/1231	182/7206	1.10053153318e-06
ko04070	Phosphatidylinositol signaling system	40/1231	112/7206	1.56949385878e-06
ko04072	Phospholipase D signaling pathway	60/1231	197/7206	2.91819777036e-06
ko04966	Collecting duct acid secretion	15/1231	26/7206	3.34142428013e-06
ko05203	Viral carcinogenesis	21/1231	277/7206	4.22197232054e-06
ko04014	Ras signaling pathway	78/1231	279/7206	4.43570018615e-06
ko04972	Pancreatic secretion	39/1231	111/7206	4.79276972666e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1231	74/7206	5.65371740556e-06
ko05030	Cocaine addiction	28/1231	73/7206	1.23140140242e-05
ko04540	Gap junction	42/1231	128/7206	1.32082971611e-05
ko04010	MAPK signaling pathway	85/1231	321/7206	1.37252488692e-05
ko04740	Olfactory transduction	30/1231	80/7206	1.43733812251e-05
ko04514	Cell adhesion molecules (CAMs)	42/1231	130/7206	1.70872953458e-05
ko04730	Long-term depression	29/1231	78/7206	2.3086500917e-05
ko04120	Ubiquitin mediated proteolysis	7/1231	138/7206	3.03996745997e-05
ko04976	Bile secretion	29/1231	80/7206	3.28482947118e-05
ko04110	Cell cycle	8/1231	145/7206	4.68350516726e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1231	122/7206	4.71612886527e-05
ko04621	NOD-like receptor signaling pathway	10/1231	157/7206	9.62490512466e-05
ko05164	Influenza A	11/1231	167/7206	9.78436306718e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1231	79/7206	0.000112700292537
ko04060	Cytokine-cytokine receptor interaction	14/1231	191/7206	0.000123087528813
ko04915	Estrogen signaling pathway	40/1231	131/7206	0.000140386701824
ko04371	Apelin signaling pathway	50/1231	177/7206	0.000164006719227
ko05414	Dilated cardiomyopathy	35/1231	112/7206	0.000196864697815
ko04141	Protein processing in endoplasmic reticulum	14/1231	184/7206	0.000219751638338
ko04745	Phototransduction - fly	16/1231	38/7206	0.000245284020648
ko05110	Vibrio cholerae infection	23/1231	63/7206	0.000263115510094
ko04923	Regulation of lipolysis in adipocytes	26/1231	77/7206	0.00034386121193
ko04710	Circadian rhythm	17/1231	43/7206	0.00039003240086
ko04924	Renin secretion	28/1231	86/7206	0.000421288415497
ko04964	Proximal tubule bicarbonate reclamation	13/1231	29/7206	0.000449206987414
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1231	59/7206	0.000663530191497
ko04612	Antigen processing and presentation	3/1231	77/7206	0.00067523397001
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1231	79/7206	0.000726476616707
ko05140	Leishmaniasis	3/1231	75/7206	0.000989199195565
ko04626	Plant-pathogen interaction	9/1231	18/7206	0.00133739703825
ko04260	Cardiac muscle contraction	29/1231	98/7206	0.00177053113883
ko04064	NF-kappa B signaling pathway	6/1231	96/7206	0.00248714450526
ko04015	Rap1 signaling pathway	67/1231	278/7206	0.00252571362815
ko03420	Nucleotide excision repair	1/1231	46/7206	0.00282464279888
ko04930	Type II diabetes mellitus	18/1231	54/7206	0.0031749835492
ko04973	Carbohydrate digestion and absorption	15/1231	42/7206	0.00318829830036
ko05231	Choline metabolism in cancer	36/1231	134/7206	0.00367066272983
ko00562	Inositol phosphate metabolism	26/1231	89/7206	0.00416572767949
ko03022	Basal transcription factors	1/1231	44/7206	0.00425301463925
ko05144	Malaria	1/1231	45/7206	0.00436531599634
ko00071	Fatty acid degradation	1/1231	45/7206	0.00436531599634
ko04270	Vascular smooth muscle contraction	40/1231	154/7206	0.00468973841944
ko04213	Longevity regulating pathway - multiple species	25/1231	86/7206	0.00558015732486
ko04922	Glucagon signaling pathway	34/1231	128/7206	0.00615123715782
ko04622	RIG-I-like receptor signaling pathway	3/1231	62/7206	0.00623235159671
ko05169	Epstein-Barr virus infection	21/1231	206/7206	0.00628898956635
ko05205	Proteoglycans in cancer	30/1231	271/7206	0.00646728023922
ko05214	Glioma	23/1231	79/7206	0.0066215540871
ko04146	Peroxisome	6/1231	89/7206	0.0066218569082
ko05133	Pertussis	6/1231	87/7206	0.00918009307911
ko00330	Arginine and proline metabolism	3/1231	61/7206	0.00921131573031
ko05162	Measles	10/1231	120/7206	0.00960895637313
ko04610	Complement and coagulation cascades	5/1231	79/7206	0.00964885174305
ko00240	Pyrimidine metabolism	9/1231	110/7206	0.0102358846187
ko04912	GnRH signaling pathway	32/1231	122/7206	0.0103222977473
ko04960	Aldosterone-regulated sodium reabsorption	14/1231	41/7206	0.0103910347446
ko04217	Necroptosis	18/1231	178/7206	0.0113528210868
ko05145	Toxoplasmosis	11/1231	126/7206	0.0115317020355
ko00380	Tryptophan metabolism	2/1231	50/7206	0.0124155846669
ko03018	RNA degradation	6/1231	84/7206	0.0124851222888
ko03410	Base excision repair	1/1231	38/7206	0.0150145889583
ko05131	Shigellosis	6/1231	82/7206	0.017181313765
ko05161	Hepatitis B	18/1231	173/7206	0.0181892974181
ko00280	Valine, leucine and isoleucine degradation	3/1231	54/7206	0.0182346384548
ko00480	Glutathione metabolism	3/1231	55/7206	0.0182561661736
ko04640	Hematopoietic cell lineage	4/1231	64/7206	0.018411137632
ko05321	Inflammatory bowel disease (IBD)	3/1231	56/7206	0.0187174409988
ko04658	Th1 and Th2 cell differentiation	8/1231	96/7206	0.0197276008152
ko04918	Thyroid hormone synthesis	23/1231	86/7206	0.0209245595396
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1231	14/7206	0.0213051956032
ko04657	IL-17 signaling pathway	7/1231	87/7206	0.0214087736536
ko00860	Porphyrin and chlorophyll metabolism	1/1231	34/7206	0.0216362019828
ko04062	Chemokine signaling pathway	47/1231	201/7206	0.0220176324277
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1231	100/7206	0.0223270437164
ko03320	PPAR signaling pathway	5/1231	69/7206	0.0245198553467
ko00590	Arachidonic acid metabolism	3/1231	52/7206	0.0258013045553
ko04916	Melanogenesis	34/1231	142/7206	0.0323063491194
ko05230	Central carbon metabolism in cancer	21/1231	81/7206	0.0379668677483
ko04114	Oocyte meiosis	33/1231	139/7206	0.0402793450475
ko00310	Lysine degradation	6/1231	73/7206	0.0418896521286
ko04115	p53 signaling pathway	6/1231	74/7206	0.0421905514524
ko04722	Neurotrophin signaling pathway	37/1231	160/7206	0.0436561359162
ko05340	Primary immunodeficiency	1/1231	30/7206	0.0487201556088