ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 50/545 191/7206 1.49403865206e-15 ko05340 Primary immunodeficiency 15/545 30/7206 6.7181917089e-10 ko04650 Natural killer cell mediated cytotoxicity 26/545 97/7206 6.67729090818e-09 ko05321 Inflammatory bowel disease (IBD) 19/545 56/7206 1.09504532511e-08 ko04380 Osteoclast differentiation 31/545 134/7206 1.13057123793e-08 ko05164 Influenza A 35/545 167/7206 1.97056563802e-08 ko05162 Measles 27/545 120/7206 1.86792430875e-07 ko04610 Complement and coagulation cascades 21/545 79/7206 2.25340769048e-07 ko05330 Allograft rejection 11/545 24/7206 4.22083714246e-07 ko05168 Herpes simplex infection 34/545 182/7206 5.82677514058e-07 ko04640 Hematopoietic cell lineage 18/545 64/7206 6.67352214208e-07 ko04659 Th17 cell differentiation 24/545 106/7206 7.98318395011e-07 ko04621 NOD-like receptor signaling pathway 30/545 157/7206 1.66363066429e-06 ko05140 Leishmaniasis 19/545 75/7206 1.89215422075e-06 ko05332 Graft-versus-host disease 9/545 18/7206 1.98601184496e-06 ko04612 Antigen processing and presentation 19/545 77/7206 2.90219697516e-06 ko04217 Necroptosis 32/545 178/7206 3.69414711061e-06 ko05320 Autoimmune thyroid disease 11/545 29/7206 4.1226333895e-06 ko04630 Jak-STAT signaling pathway 26/545 132/7206 4.61028056353e-06 ko05145 Toxoplasmosis 25/545 126/7206 6.13523759135e-06 ko05150 Staphylococcus aureus infection 12/545 36/7206 7.20362211029e-06 ko04137 Mitophagy - animal 19/545 82/7206 7.87559009296e-06 ko04672 Intestinal immune network for IgA production 12/545 37/7206 9.93854813752e-06 ko04620 Toll-like receptor signaling pathway 21/545 100/7206 1.36658487563e-05 ko05152 Tuberculosis 31/545 187/7206 2.90704302911e-05 ko03013 RNA transport 1/545 166/7206 4.27987184503e-05 ko04660 T cell receptor signaling pathway 23/545 124/7206 4.4711207607e-05 ko04658 Th1 and Th2 cell differentiation 19/545 96/7206 8.24756044382e-05 ko04064 NF-kappa B signaling pathway 19/545 96/7206 8.24756044382e-05 ko05167 Kaposi's sarcoma-associated herpesvirus infection 30/545 191/7206 0.000124797636793 ko03040 Spliceosome 1/545 145/7206 0.000204573481431 ko04710 Circadian rhythm 11/545 43/7206 0.000258503233756 ko05144 Malaria 11/545 45/7206 0.00039711594556 ko04940 Type I diabetes mellitus 9/545 32/7206 0.000438291576484 ko03010 Ribosome 1/545 129/7206 0.00103747331996 ko05310 Asthma 6/545 17/7206 0.00109427070359 ko05034 Alcoholism 6/545 238/7206 0.00109734367312 ko00590 Arachidonic acid metabolism 11/545 52/7206 0.00145652276213 ko04390 Hippo signaling pathway 4/545 188/7206 0.00187313415539 ko00592 alpha-Linolenic acid metabolism 6/545 19/7206 0.00210566458186 ko00120 Primary bile acid biosynthesis 6/545 20/7206 0.0028186516548 ko04662 B cell receptor signaling pathway 15/545 88/7206 0.00320154687258 ko05323 Rheumatoid arthritis 15/545 89/7206 0.00340287616131 ko00051 Fructose and mannose metabolism 9/545 42/7206 0.00353149124013 ko04145 Phagosome 23/545 162/7206 0.0036499435996 ko04062 Chemokine signaling pathway 27/545 201/7206 0.00397489089255 ko05230 Central carbon metabolism in cancer 14/545 81/7206 0.00438529693935 ko04068 FoxO signaling pathway 23/545 167/7206 0.00443661982448 ko04723 Retrograde endocannabinoid signaling 4/545 175/7206 0.00525718562305 ko04110 Cell cycle 3/545 145/7206 0.00652333927681 ko04728 Dopaminergic synapse 5/545 185/7206 0.00709074596034 ko05161 Hepatitis B 23/545 173/7206 0.0079200242283 ko03015 mRNA surveillance pathway 1/545 93/7206 0.00944276757372 ko04310 Wnt signaling pathway 5/545 181/7206 0.00971129933211 ko05142 Chagas disease (American trypanosomiasis) 18/545 130/7206 0.0110233445816 ko04666 Fc gamma R-mediated phagocytosis 17/545 122/7206 0.0138901591938 ko04111 Cell cycle - yeast 1/545 90/7206 0.0140642664894 ko04391 Hippo signaling pathway - fly 1/545 90/7206 0.0140642664894 ko03050 Proteasome 9/545 54/7206 0.0187991261557 ko00982 Drug metabolism - cytochrome P450 7/545 37/7206 0.019135630914 ko04072 Phospholipase D signaling pathway 24/545 197/7206 0.0191924117952 ko05133 Pertussis 13/545 87/7206 0.0215527423507 ko04668 TNF signaling pathway 16/545 120/7206 0.0225857511313 ko04622 RIG-I-like receptor signaling pathway 10/545 62/7206 0.0244432242934 ko04916 Melanogenesis 4/545 142/7206 0.0245578939233 ko04514 Cell adhesion molecules (CAMs) 17/545 130/7206 0.0272404598641 ko04670 Leukocyte transendothelial migration 19/545 151/7206 0.0276517367297 ko05418 Fluid shear stress and atherosclerosis 21/545 173/7206 0.0280682401459 ko05020 Prion diseases 7/545 40/7206 0.0285146779424 ko00980 Metabolism of xenobiotics by cytochrome P450 7/545 40/7206 0.0285146779424 ko05160 Hepatitis C 19/545 153/7206 0.0292663019874 ko04721 Synaptic vesicle cycle 1/545 80/7206 0.0299801191929 ko04623 Cytosolic DNA-sensing pathway 7/545 41/7206 0.032228943798 ko04611 Platelet activation 20/545 163/7206 0.0339095174048 ko00950 Isoquinoline alkaloid biosynthesis 3/545 10/7206 0.0345653433885 ko04530 Tight junction 9/545 228/7206 0.0402705117172 ko05224 Breast cancer 6/545 174/7206 0.0404372042478 ko04146 Peroxisome 12/545 89/7206 0.0422191682361 ko04724 Glutamatergic synapse 5/545 152/7206 0.0427919795363 ko04664 Fc epsilon RI signaling pathway 11/545 77/7206 0.0459161875898 ko04972 Pancreatic secretion 3/545 111/7206 0.0464927570036 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/545 5/7206 0.0489717488112