ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 50/649 191/7206 1.5320929843e-12 ko04380 Osteoclast differentiation 36/649 134/7206 1.04702303168e-09 ko04658 Th1 and Th2 cell differentiation 26/649 96/7206 1.89933282531e-07 ko04650 Natural killer cell mediated cytotoxicity 26/649 97/7206 2.37845731096e-07 ko05140 Leishmaniasis 22/649 75/7206 3.69527512031e-07 ko05340 Primary immunodeficiency 13/649 30/7206 6.44183906206e-07 ko05321 Inflammatory bowel disease (IBD) 18/649 56/7206 9.68375789417e-07 ko04659 Th17 cell differentiation 26/649 106/7206 1.53866799137e-06 ko05145 Toxoplasmosis 29/649 126/7206 1.5884771527e-06 ko04672 Intestinal immune network for IgA production 14/649 37/7206 1.72842909885e-06 ko04610 Complement and coagulation cascades 21/649 79/7206 3.97770490844e-06 ko05152 Tuberculosis 36/649 187/7206 1.14473511069e-05 ko05330 Allograft rejection 10/649 24/7206 1.99964064373e-05 ko05320 Autoimmune thyroid disease 11/649 29/7206 2.21724279937e-05 ko03040 Spliceosome 1/649 145/7206 2.60595908834e-05 ko04621 NOD-like receptor signaling pathway 30/649 157/7206 5.80971566608e-05 ko05162 Measles 25/649 120/7206 6.17327565829e-05 ko04710 Circadian rhythm 13/649 43/7206 6.52801670241e-05 ko04660 T cell receptor signaling pathway 25/649 124/7206 9.69562143543e-05 ko04640 Hematopoietic cell lineage 16/649 64/7206 0.000124547917564 ko03010 Ribosome 1/649 129/7206 0.000129856726072 ko03013 RNA transport 3/649 166/7206 0.000274367386962 ko05164 Influenza A 30/649 167/7206 0.000283028059726 ko04064 NF-kappa B signaling pathway 20/649 96/7206 0.000390872793131 ko05167 Kaposi's sarcoma-associated herpesvirus infection 32/649 191/7206 0.000474740082845 ko05332 Graft-versus-host disease 7/649 18/7206 0.000611285339354 ko05034 Alcoholism 8/649 238/7206 0.000782906622991 ko05150 Staphylococcus aureus infection 10/649 36/7206 0.000957588457019 ko00120 Primary bile acid biosynthesis 7/649 20/7206 0.00126899714397 ko04630 Jak-STAT signaling pathway 23/649 132/7206 0.00181608416099 ko04662 B cell receptor signaling pathway 17/649 88/7206 0.00214137639424 ko05168 Herpes simplex infection 29/649 182/7206 0.00226326037825 ko05323 Rheumatoid arthritis 17/649 89/7206 0.00237829973868 ko05310 Asthma 6/649 17/7206 0.00271410733849 ko04137 Mitophagy - animal 16/649 82/7206 0.00271927182101 ko04022 cGMP-PKG signaling pathway 32/649 216/7206 0.0050582576087 ko00592 alpha-Linolenic acid metabolism 6/649 19/7206 0.00509109012283 ko01040 Biosynthesis of unsaturated fatty acids 7/649 25/7206 0.00528790164183 ko04068 FoxO signaling pathway 26/649 167/7206 0.0056261431027 ko04933 AGE-RAGE signaling pathway in diabetic complications 22/649 135/7206 0.00566899763158 ko05144 Malaria 10/649 45/7206 0.0057370422345 ko04020 Calcium signaling pathway 37/649 265/7206 0.00611925039883 ko04940 Type I diabetes mellitus 8/649 32/7206 0.00620454080693 ko04922 Glucagon signaling pathway 21/649 128/7206 0.00710055764446 ko04217 Necroptosis 27/649 178/7206 0.00731855802607 ko00350 Tyrosine metabolism 8/649 33/7206 0.0075595351546 ko04145 Phagosome 25/649 162/7206 0.00759701564818 ko00051 Fructose and mannose metabolism 9/649 42/7206 0.0109744823825 ko04620 Toll-like receptor signaling pathway 17/649 100/7206 0.0120154115262 ko05160 Hepatitis C 23/649 153/7206 0.0141837147926 ko00360 Phenylalanine metabolism 5/649 17/7206 0.0144510540403 ko04072 Phospholipase D signaling pathway 28/649 197/7206 0.015600346663 ko04391 Hippo signaling pathway - fly 2/649 90/7206 0.015761670823 ko03015 mRNA surveillance pathway 2/649 93/7206 0.0160598741637 ko04066 HIF-1 signaling pathway 19/649 123/7206 0.0167430983382 ko05230 Central carbon metabolism in cancer 14/649 81/7206 0.0167441314591 ko04062 Chemokine signaling pathway 28/649 201/7206 0.0173641755549 ko04070 Phosphatidylinositol signaling system 18/649 112/7206 0.0179871595229 ko04113 Meiosis - yeast 1/649 70/7206 0.0192544119331 ko00590 Arachidonic acid metabolism 10/649 52/7206 0.0233399165881 ko04711 Circadian rhythm - fly 4/649 13/7206 0.0241079085437 ko04612 Antigen processing and presentation 13/649 77/7206 0.0249036108973 ko05142 Chagas disease (American trypanosomiasis) 19/649 130/7206 0.0300368302502 ko04514 Cell adhesion molecules (CAMs) 19/649 130/7206 0.0300368302502 ko05418 Fluid shear stress and atherosclerosis 24/649 173/7206 0.0305808624403 ko04668 TNF signaling pathway 18/649 120/7206 0.0342472729014 ko04666 Fc gamma R-mediated phagocytosis 18/649 122/7206 0.036090212796 ko04110 Cell cycle 6/649 145/7206 0.0389029112192 ko04670 Leukocyte transendothelial migration 21/649 151/7206 0.0428673468281 ko05224 Breast cancer 8/649 174/7206 0.0429425981419 ko04921 Oxytocin signaling pathway 27/649 209/7206 0.0496620924319