ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	117/653	423/7206	9.7059309078e-31
ko05033	Nicotine addiction	32/653	56/7206	1.12274686011e-19
ko04024	cAMP signaling pathway	69/653	279/7206	2.10547490842e-15
ko04727	GABAergic synapse	40/653	110/7206	2.29432910226e-15
ko05032	Morphine addiction	40/653	110/7206	2.29432910226e-15
ko04724	Glutamatergic synapse	47/653	152/7206	1.05637025894e-14
ko04713	Circadian entrainment	42/653	136/7206	3.05321238981e-13
ko04723	Retrograde endocannabinoid signaling	46/653	175/7206	1.32471977229e-11
ko04911	Insulin secretion	34/653	117/7206	3.7084658449e-10
ko04020	Calcium signaling pathway	56/653	265/7206	1.02660844337e-09
ko04744	Phototransduction	17/653	36/7206	2.54236061889e-09
ko04721	Synaptic vesicle cycle	24/653	80/7206	7.59487039672e-08
ko04921	Oxytocin signaling pathway	44/653	209/7206	1.04458879871e-07
ko04726	Serotonergic synapse	33/653	137/7206	1.11143155975e-07
ko04742	Taste transduction	20/653	61/7206	1.84592820019e-07
ko05031	Amphetamine addiction	25/653	91/7206	2.72558787146e-07
ko04728	Dopaminergic synapse	39/653	185/7206	3.74931663567e-07
ko04725	Cholinergic synapse	35/653	160/7206	7.79396952651e-07
ko05030	Cocaine addiction	20/653	73/7206	4.47295665889e-06
ko04261	Adrenergic signaling in cardiomyocytes	38/653	205/7206	1.77085027363e-05
ko04720	Long-term potentiation	23/653	99/7206	1.78772036217e-05
ko05322	Systemic lupus erythematosus	1/653	151/7206	1.83942711939e-05
ko03040	Spliceosome	1/653	145/7206	2.61998412675e-05
ko04970	Salivary secretion	22/653	95/7206	2.86086960761e-05
ko04971	Gastric acid secretion	22/653	98/7206	4.76697350347e-05
ko03010	Ribosome	1/653	129/7206	0.000132426574074
ko04972	Pancreatic secretion	23/653	111/7206	0.000144864093023
ko04730	Long-term depression	18/653	78/7206	0.000158004894951
ko05203	Viral carcinogenesis	9/653	277/7206	0.000166704033884
ko05169	Epstein-Barr virus infection	5/653	206/7206	0.000182738917007
ko04710	Circadian rhythm	12/653	43/7206	0.000305667999765
ko05168	Herpes simplex infection	4/653	182/7206	0.000327253645372
ko04070	Phosphatidylinositol signaling system	22/653	112/7206	0.000397370700668
ko04976	Bile secretion	17/653	80/7206	0.000669109267039
ko04964	Proximal tubule bicarbonate reclamation	9/653	29/7206	0.000742169256401
ko05014	Amyotrophic lateral sclerosis (ALS)	16/653	74/7206	0.000782424514983
ko05164	Influenza A	4/653	167/7206	0.000900131691959
ko04110	Cell cycle	3/653	145/7206	0.00109936587845
ko04260	Cardiac muscle contraction	19/653	98/7206	0.00117366490977
ko04925	Aldosterone synthesis and secretion	20/653	105/7206	0.00152771312049
ko04022	cGMP-PKG signaling pathway	34/653	216/7206	0.00153559455809
ko04923	Regulation of lipolysis in adipocytes	16/653	77/7206	0.00186995180178
ko05161	Hepatitis B	5/653	173/7206	0.00188472979152
ko04750	Inflammatory mediator regulation of TRP channels	22/653	122/7206	0.00200344144372
ko04072	Phospholipase D signaling pathway	31/653	197/7206	0.00224450314555
ko04960	Aldosterone-regulated sodium reabsorption	10/653	41/7206	0.00292790895214
ko04141	Protein processing in endoplasmic reticulum	6/653	184/7206	0.00376736169041
ko04657	IL-17 signaling pathway	1/653	87/7206	0.00418261787631
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/653	14/7206	0.00602165532674
ko04060	Cytokine-cytokine receptor interaction	7/653	191/7206	0.00671317591508
ko05166	HTLV-I infection	14/653	292/7206	0.00672209353162
ko05224	Breast cancer	6/653	174/7206	0.00686863053663
ko04621	NOD-like receptor signaling pathway	5/653	157/7206	0.00689036048348
ko03008	Ribosome biogenesis in eukaryotes	1/653	79/7206	0.00906962531217
ko03013	RNA transport	6/653	166/7206	0.00907169113165
ko05162	Measles	3/653	120/7206	0.00910903915054
ko05200	Pathways in cancer	29/653	492/7206	0.00917201248644
ko04010	MAPK signaling pathway	43/653	321/7206	0.00929099692949
ko00680	Methane metabolism	8/653	34/7206	0.00945951510224
ko04973	Carbohydrate digestion and absorption	9/653	42/7206	0.0114033752632
ko05215	Prostate cancer	3/653	111/7206	0.0121665895237
ko04550	Signaling pathways regulating pluripotency of stem cells	6/653	165/7206	0.0125638123615
ko04540	Gap junction	20/653	128/7206	0.0181754835498
ko04745	Phototransduction - fly	8/653	38/7206	0.0184889478628
ko05217	Basal cell carcinoma	1/653	68/7206	0.0191234827702
ko04961	Endocrine and other factor-regulated calcium reabsorption	11/653	59/7206	0.0191423141624
ko04214	Apoptosis - fly	1/653	72/7206	0.0202127770127
ko05160	Hepatitis C	6/653	153/7206	0.021956199338
ko05133	Pertussis	2/653	87/7206	0.0224776026393
ko04120	Ubiquitin mediated proteolysis	5/653	138/7206	0.0233343614053
ko04350	TGF-beta signaling pathway	3/653	103/7206	0.0236068926366
ko04978	Mineral absorption	8/653	40/7206	0.0247870936866
ko00561	Glycerolipid metabolism	11/653	63/7206	0.0270805188527
ko04930	Type II diabetes mellitus	10/653	54/7206	0.027310939857
ko04740	Olfactory transduction	13/653	80/7206	0.0310392562
ko01230	Biosynthesis of amino acids	14/653	85/7206	0.0333191133179
ko04924	Renin secretion	14/653	86/7206	0.03428288137
ko04151	PI3K-Akt signaling pathway	24/653	390/7206	0.0370974880853
ko00562	Inositol phosphate metabolism	14/653	89/7206	0.0384352415844
ko05202	Transcriptional misregulation in cancer	9/653	188/7206	0.0385444517769
ko04330	Notch signaling pathway	1/653	62/7206	0.0415804408028
ko04622	RIG-I-like receptor signaling pathway	1/653	62/7206	0.0415804408028
ko04014	Ras signaling pathway	35/653	279/7206	0.0431434317426
ko00290	Valine, leucine and isoleucine biosynthesis	2/653	4/7206	0.0434744353536
ko04612	Antigen processing and presentation	2/653	77/7206	0.0445492476404
ko03015	mRNA surveillance pathway	3/653	93/7206	0.0450153530512
ko04658	Th1 and Th2 cell differentiation	3/653	96/7206	0.0461414217778
ko04064	NF-kappa B signaling pathway	3/653	96/7206	0.0461414217778
ko04150	mTOR signaling pathway	9/653	184/7206	0.0497412088071