ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	203/1226	423/7206	8.27954646096e-53
ko04724	Glutamatergic synapse	91/1226	152/7206	3.00203077014e-33
ko05033	Nicotine addiction	47/1226	56/7206	5.20945909804e-28
ko05032	Morphine addiction	69/1226	110/7206	3.59945737287e-27
ko04713	Circadian entrainment	77/1226	136/7206	4.94347850741e-26
ko04727	GABAergic synapse	67/1226	110/7206	2.48309596277e-25
ko04728	Dopaminergic synapse	88/1226	185/7206	1.67790628999e-22
ko04725	Cholinergic synapse	79/1226	160/7206	1.39992878909e-21
ko04721	Synaptic vesicle cycle	50/1226	80/7206	6.77480575005e-20
ko04024	cAMP signaling pathway	108/1226	279/7206	1.27017334303e-18
ko04723	Retrograde endocannabinoid signaling	79/1226	175/7206	1.41884952012e-18
ko04020	Calcium signaling pathway	101/1226	265/7206	5.3438858226e-17
ko04911	Insulin secretion	58/1226	117/7206	3.01522518711e-16
ko04726	Serotonergic synapse	63/1226	137/7206	1.60419369888e-15
ko04742	Taste transduction	37/1226	61/7206	1.90480016772e-14
ko04921	Oxytocin signaling pathway	81/1226	209/7206	3.10709521948e-14
ko04744	Phototransduction	26/1226	36/7206	3.53167845996e-13
ko04970	Salivary secretion	44/1226	95/7206	2.35094820928e-11
ko03040	Spliceosome	1/1226	145/7206	7.10708477328e-11
ko05031	Amphetamine addiction	42/1226	91/7206	7.7299617447e-11
ko04261	Adrenergic signaling in cardiomyocytes	73/1226	205/7206	7.7382136178e-11
ko04720	Long-term potentiation	43/1226	99/7206	5.11528913471e-10
ko04925	Aldosterone synthesis and secretion	43/1226	105/7206	7.33246821517e-09
ko04971	Gastric acid secretion	39/1226	98/7206	7.20561327621e-08
ko05203	Viral carcinogenesis	17/1226	277/7206	7.73439488143e-08
ko04740	Olfactory transduction	33/1226	80/7206	2.37196417631e-07
ko05322	Systemic lupus erythematosus	5/1226	151/7206	2.50531423948e-07
ko05030	Cocaine addiction	31/1226	73/7206	2.51811800766e-07
ko04022	cGMP-PKG signaling pathway	67/1226	216/7206	2.77830475778e-07
ko03013	RNA transport	7/1226	166/7206	5.68866984546e-07
ko05168	Herpes simplex infection	9/1226	182/7206	1.0888209324e-06
ko04360	Axon guidance	69/1226	233/7206	1.26250727399e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1226	74/7206	5.32750899367e-06
ko05164	Influenza A	9/1226	167/7206	8.95177161083e-06
ko04972	Pancreatic secretion	38/1226	111/7206	9.24226199123e-06
ko04070	Phosphatidylinositol signaling system	38/1226	112/7206	1.09063759579e-05
ko04514	Cell adhesion molecules (CAMs)	42/1226	130/7206	1.59752093684e-05
ko04966	Collecting duct acid secretion	14/1226	26/7206	2.00176558162e-05
ko04730	Long-term depression	29/1226	78/7206	2.23027695517e-05
ko04540	Gap junction	41/1226	128/7206	2.46836071199e-05
ko04060	Cytokine-cytokine receptor interaction	13/1226	191/7206	5.14096397285e-05
ko04924	Renin secretion	30/1226	86/7206	6.10267847607e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1226	79/7206	6.27918275781e-05
ko05414	Dilated cardiomyopathy	36/1226	112/7206	6.89649026116e-05
ko04010	MAPK signaling pathway	82/1226	321/7206	7.19055654732e-05
ko04014	Ras signaling pathway	73/1226	279/7206	8.60662403944e-05
ko04141	Protein processing in endoplasmic reticulum	13/1226	184/7206	9.26216885235e-05
ko04621	NOD-like receptor signaling pathway	10/1226	157/7206	9.69940182838e-05
ko04923	Regulation of lipolysis in adipocytes	27/1226	77/7206	0.000103251660285
ko04072	Phospholipase D signaling pathway	55/1226	197/7206	0.000104281169721
ko03008	Ribosome biogenesis in eukaryotes	2/1226	79/7206	0.000111367282952
ko04750	Inflammatory mediator regulation of TRP channels	38/1226	122/7206	0.000126291247746
ko04745	Phototransduction - fly	16/1226	38/7206	0.000233620401917
ko04976	Bile secretion	27/1226	80/7206	0.000242930974301
ko04120	Ubiquitin mediated proteolysis	9/1226	138/7206	0.000353868100079
ko04110	Cell cycle	10/1226	145/7206	0.000478616777074
ko05110	Vibrio cholerae infection	22/1226	63/7206	0.000543106012065
ko04915	Estrogen signaling pathway	38/1226	131/7206	0.00057746873002
ko04612	Antigen processing and presentation	3/1226	77/7206	0.000678789979114
ko05140	Leishmaniasis	3/1226	75/7206	0.000989584911237
ko05162	Measles	8/1226	120/7206	0.00129343960361
ko04626	Plant-pathogen interaction	9/1226	18/7206	0.00129757124618
ko04964	Proximal tubule bicarbonate reclamation	12/1226	29/7206	0.00168703431884
ko04260	Cardiac muscle contraction	29/1226	98/7206	0.00169983955662
ko05169	Epstein-Barr virus infection	19/1226	206/7206	0.00179622344502
ko05161	Hepatitis B	15/1226	173/7206	0.00201767777338
ko05205	Proteoglycans in cancer	28/1226	271/7206	0.00220384964634
ko04371	Apelin signaling pathway	46/1226	177/7206	0.00224045542743
ko04270	Vascular smooth muscle contraction	41/1226	154/7206	0.00227605447665
ko05410	Hypertrophic cardiomyopathy (HCM)	29/1226	100/7206	0.00283208326186
ko03420	Nucleotide excision repair	1/1226	46/7206	0.00284399109588
ko03022	Basal transcription factors	1/1226	44/7206	0.00426695277175
ko05144	Malaria	1/1226	45/7206	0.00434711771197
ko00071	Fatty acid degradation	1/1226	45/7206	0.00434711771197
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1226	59/7206	0.00446647039349
ko04622	RIG-I-like receptor signaling pathway	3/1226	62/7206	0.0062576005671
ko04146	Peroxisome	6/1226	89/7206	0.00662719049904
ko00310	Lysine degradation	4/1226	73/7206	0.00689546432137
ko04064	NF-kappa B signaling pathway	7/1226	96/7206	0.00877738733028
ko05133	Pertussis	6/1226	87/7206	0.00915357428076
ko04930	Type II diabetes mellitus	17/1226	54/7206	0.00944590345457
ko04610	Complement and coagulation cascades	5/1226	79/7206	0.00957338568318
ko00562	Inositol phosphate metabolism	25/1226	89/7206	0.00973922643929
ko04912	GnRH signaling pathway	32/1226	122/7206	0.0101258199131
ko04217	Necroptosis	18/1226	178/7206	0.0113410930628
ko05219	Bladder cancer	2/1226	48/7206	0.0117814889367
ko03018	RNA degradation	6/1226	84/7206	0.0124834158986
ko04710	Circadian rhythm	14/1226	43/7206	0.0125539991694
ko03410	Base excision repair	1/1226	38/7206	0.0149397495958
ko05131	Shigellosis	6/1226	82/7206	0.0171244729666
ko04214	Apoptosis - fly	5/1226	72/7206	0.0178778647416
ko00480	Glutathione metabolism	3/1226	55/7206	0.0182599122406
ko04115	p53 signaling pathway	5/1226	74/7206	0.0183242357395
ko04658	Th1 and Th2 cell differentiation	8/1226	96/7206	0.0197532321551
ko04918	Thyroid hormone synthesis	23/1226	86/7206	0.0204554642603
ko05166	HTLV-I infection	35/1226	292/7206	0.0207942047243
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1226	14/7206	0.0209027305769
ko04657	IL-17 signaling pathway	7/1226	87/7206	0.0214670196042
ko00860	Porphyrin and chlorophyll metabolism	1/1226	34/7206	0.0217074949213
ko00500	Starch and sucrose metabolism	1/1226	35/7206	0.0219070881684
ko04015	Rap1 signaling pathway	62/1226	278/7206	0.022278476715
ko04973	Carbohydrate digestion and absorption	13/1226	42/7206	0.0225157281952
ko05145	Toxoplasmosis	12/1226	126/7206	0.0225968847451
ko00590	Arachidonic acid metabolism	3/1226	52/7206	0.0258636864109
ko00280	Valine, leucine and isoleucine degradation	3/1226	54/7206	0.0268803293171
ko04932	Non-alcoholic fatty liver disease (NAFLD)	20/1226	182/7206	0.0276614131871
ko00240	Pyrimidine metabolism	10/1226	110/7206	0.0286409289761
ko05202	Transcriptional misregulation in cancer	21/1226	188/7206	0.0302109142067
ko04916	Melanogenesis	34/1226	142/7206	0.0317016047521
ko04922	Glucagon signaling pathway	31/1226	128/7206	0.0326420987371
ko03320	PPAR signaling pathway	5/1226	69/7206	0.0344721932345
ko05231	Choline metabolism in cancer	32/1226	134/7206	0.0367449655455
ko04114	Oocyte meiosis	33/1226	139/7206	0.0396290827699
ko00230	Purine metabolism	44/1226	194/7206	0.0413150975678
ko04213	Longevity regulating pathway - multiple species	22/1226	86/7206	0.042153035077
ko05206	MicroRNAs in cancer	20/1226	177/7206	0.0423426509284
ko04510	Focal adhesion	29/1226	240/7206	0.0439331706215
ko04062	Chemokine signaling pathway	45/1226	201/7206	0.0452509000091
ko04640	Hematopoietic cell lineage	5/1226	64/7206	0.0457198577131
ko04630	Jak-STAT signaling pathway	14/1226	132/7206	0.0469726597229
ko05320	Autoimmune thyroid disease	1/1226	29/7206	0.048336471987
ko05340	Primary immunodeficiency	1/1226	30/7206	0.0486662450545
ko05321	Inflammatory bowel disease (IBD)	4/1226	56/7206	0.0489279792922