ko pathway ratio_in_study ratio_in_pop p_value ko04380 Osteoclast differentiation 27/218 134/7206 1.70606824208e-15 ko04060 Cytokine-cytokine receptor interaction 31/218 191/7206 6.99546931528e-15 ko05140 Leishmaniasis 20/218 75/7206 3.19746587754e-14 ko04064 NF-kappa B signaling pathway 22/218 96/7206 4.87879787011e-14 ko05162 Measles 22/218 120/7206 6.0961044695e-12 ko04660 T cell receptor signaling pathway 22/218 124/7206 1.20969906416e-11 ko05340 Primary immunodeficiency 12/218 30/7206 2.32758979472e-11 ko05152 Tuberculosis 26/218 187/7206 4.76113470362e-11 ko04650 Natural killer cell mediated cytotoxicity 19/218 97/7206 5.40761327332e-11 ko04620 Toll-like receptor signaling pathway 19/218 100/7206 9.45748862026e-11 ko05164 Influenza A 24/218 167/7206 1.38292486647e-10 ko05145 Toxoplasmosis 20/218 126/7206 8.66285458648e-10 ko04621 NOD-like receptor signaling pathway 22/218 157/7206 1.39578011614e-09 ko04630 Jak-STAT signaling pathway 20/218 132/7206 2.01892307858e-09 ko05150 Staphylococcus aureus infection 11/218 36/7206 4.66789965139e-09 ko05144 Malaria 12/218 45/7206 5.18067575445e-09 ko05321 Inflammatory bowel disease (IBD) 13/218 56/7206 7.4459828236e-09 ko05133 Pertussis 15/218 87/7206 3.8455066265e-08 ko04662 B cell receptor signaling pathway 15/218 88/7206 4.512902818e-08 ko05142 Chagas disease (American trypanosomiasis) 18/218 130/7206 5.69702722969e-08 ko04217 Necroptosis 21/218 178/7206 7.50834508058e-08 ko04672 Intestinal immune network for IgA production 10/218 37/7206 8.90303160196e-08 ko05168 Herpes simplex infection 21/218 182/7206 1.10629162661e-07 ko05330 Allograft rejection 8/218 24/7206 2.98978154477e-07 ko04668 TNF signaling pathway 16/218 120/7206 5.42597840451e-07 ko04659 Th17 cell differentiation 15/218 106/7206 5.68811732103e-07 ko04664 Fc epsilon RI signaling pathway 12/218 77/7206 2.81492839174e-06 ko05161 Hepatitis B 18/218 173/7206 4.22625525959e-06 ko05310 Asthma 6/218 17/7206 6.69991086701e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 18/218 191/7206 1.6919318679e-05 ko05320 Autoimmune thyroid disease 7/218 29/7206 1.86325399173e-05 ko04623 Cytosolic DNA-sensing pathway 8/218 41/7206 2.49104950927e-05 ko04658 Th1 and Th2 cell differentiation 12/218 96/7206 2.88267414291e-05 ko05143 African trypanosomiasis 7/218 32/7206 3.71901548045e-05 ko05323 Rheumatoid arthritis 11/218 89/7206 6.92507688156e-05 ko04666 Fc gamma R-mediated phagocytosis 13/218 122/7206 7.40245038324e-05 ko04612 Antigen processing and presentation 10/218 77/7206 9.72416068123e-05 ko04210 Apoptosis 16/218 180/7206 0.000101984872334 ko04640 Hematopoietic cell lineage 9/218 64/7206 0.000116589748356 ko05332 Graft-versus-host disease 5/218 18/7206 0.000150263282781 ko04940 Type I diabetes mellitus 6/218 32/7206 0.000335381469085 ko05134 Legionellosis 9/218 74/7206 0.000360090838653 ko04622 RIG-I-like receptor signaling pathway 8/218 62/7206 0.000510671604863 ko05132 Salmonella infection 10/218 98/7206 0.000714078114743 ko05131 Shigellosis 9/218 82/7206 0.000774663240687 ko04062 Chemokine signaling pathway 15/218 201/7206 0.00108783418517 ko04611 Platelet activation 13/218 163/7206 0.00127359269653 ko05160 Hepatitis C 12/218 153/7206 0.00224101767774 ko04610 Complement and coagulation cascades 8/218 79/7206 0.00253951830201 ko05146 Amoebiasis 9/218 99/7206 0.00293893015631 ko05166 HTLV-I infection 18/218 292/7206 0.00423534128991 ko05169 Epstein-Barr virus infection 14/218 206/7206 0.005398954185 ko04670 Leukocyte transendothelial migration 11/218 151/7206 0.00592658252184 ko04933 AGE-RAGE signaling pathway in diabetic complications 10/218 135/7206 0.00762390335587 ko04145 Phagosome 11/218 162/7206 0.00988051129879 ko04514 Cell adhesion molecules (CAMs) 9/218 130/7206 0.0167703365205 ko04144 Endocytosis 18/218 342/7206 0.0217072058705 ko05016 Huntington's disease 1/218 215/7206 0.0229526855247 ko05416 Viral myocarditis 5/218 55/7206 0.0247087157611 ko05130 Pathogenic Escherichia coli infection 6/218 77/7206 0.0285610043487 ko05020 Prion diseases 4/218 40/7206 0.0318122468709 ko04310 Wnt signaling pathway 1/218 181/7206 0.0454868784572 ko04917 Prolactin signaling pathway 6/218 87/7206 0.0476102617137 ko04657 IL-17 signaling pathway 6/218 87/7206 0.0476102617137 ko04142 Lysosome 9/218 151/7206 0.0484337363287