ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	204/1270	423/7206	7.91159992895e-51
ko04724	Glutamatergic synapse	92/1270	152/7206	7.11490797036e-33
ko05033	Nicotine addiction	49/1270	56/7206	3.40473513593e-30
ko04713	Circadian entrainment	80/1270	136/7206	1.71893936727e-27
ko05032	Morphine addiction	70/1270	110/7206	3.87025311406e-27
ko04727	GABAergic synapse	66/1270	110/7206	1.54292537938e-23
ko04721	Synaptic vesicle cycle	53/1270	80/7206	4.9166121571e-22
ko04725	Cholinergic synapse	78/1270	160/7206	6.55572014528e-20
ko04728	Dopaminergic synapse	85/1270	185/7206	1.70716954924e-19
ko04723	Retrograde endocannabinoid signaling	80/1270	175/7206	3.03522781107e-18
ko04024	cAMP signaling pathway	107/1270	279/7206	5.42491911967e-17
ko04020	Calcium signaling pathway	103/1270	265/7206	7.1195276665e-17
ko04911	Insulin secretion	59/1270	117/7206	3.26242072219e-16
ko04726	Serotonergic synapse	64/1270	137/7206	2.1600382365e-15
ko04742	Taste transduction	37/1270	61/7206	6.03117696931e-14
ko04921	Oxytocin signaling pathway	82/1270	209/7206	8.12854888977e-14
ko04744	Phototransduction	26/1270	36/7206	8.30977650409e-13
ko05031	Amphetamine addiction	45/1270	91/7206	2.77746530545e-12
ko04970	Salivary secretion	45/1270	95/7206	1.8443073758e-11
ko04261	Adrenergic signaling in cardiomyocytes	76/1270	205/7206	1.92472836109e-11
ko04720	Long-term potentiation	46/1270	99/7206	2.54567268437e-11
ko03040	Spliceosome	2/1270	145/7206	3.6692167676e-10
ko04740	Olfactory transduction	36/1270	80/7206	1.09941363804e-08
ko05030	Cocaine addiction	33/1270	73/7206	3.92571289595e-08
ko05203	Viral carcinogenesis	18/1270	277/7206	5.06802346745e-08
ko04971	Gastric acid secretion	40/1270	98/7206	5.48172536996e-08
ko04925	Aldosterone synthesis and secretion	42/1270	105/7206	7.55940909096e-08
ko04022	cGMP-PKG signaling pathway	70/1270	216/7206	8.8997833766e-08
ko05322	Systemic lupus erythematosus	5/1270	151/7206	1.06757011581e-07
ko03013	RNA transport	7/1270	166/7206	2.52124128922e-07
ko05168	Herpes simplex infection	9/1270	182/7206	3.41941745093e-07
ko04060	Cytokine-cytokine receptor interaction	10/1270	191/7206	3.81449946732e-07
ko04360	Axon guidance	71/1270	233/7206	1.11819246893e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1270	74/7206	3.32150986642e-06
ko04966	Collecting duct acid secretion	15/1270	26/7206	5.00693976479e-06
ko04972	Pancreatic secretion	39/1270	111/7206	7.46398616872e-06
ko04924	Renin secretion	32/1270	86/7206	1.23015229927e-05
ko05164	Influenza A	10/1270	167/7206	1.24136244388e-05
ko04621	NOD-like receptor signaling pathway	9/1270	157/7206	1.69731348963e-05
ko04976	Bile secretion	30/1270	80/7206	2.07478117878e-05
ko04745	Phototransduction - fly	18/1270	38/7206	2.2605062268e-05
ko04540	Gap junction	42/1270	128/7206	2.9899179008e-05
ko04730	Long-term depression	29/1270	78/7206	3.37909680578e-05
ko04610	Complement and coagulation cascades	2/1270	79/7206	7.18015501275e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1270	79/7206	7.18015501275e-05
ko04010	MAPK signaling pathway	84/1270	321/7206	8.96128849772e-05
ko04110	Cell cycle	9/1270	145/7206	9.30718408469e-05
ko05110	Vibrio cholerae infection	24/1270	63/7206	9.46629774766e-05
ko04514	Cell adhesion molecules (CAMs)	41/1270	130/7206	9.9687883281e-05
ko05140	Leishmaniasis	2/1270	75/7206	0.000102447038119
ko04064	NF-kappa B signaling pathway	4/1270	96/7206	0.000119821317477
ko05169	Epstein-Barr virus infection	17/1270	206/7206	0.00013134367082
ko04260	Cardiac muscle contraction	33/1270	98/7206	0.000134312739973
ko04072	Phospholipase D signaling pathway	56/1270	197/7206	0.000134650212468
ko05414	Dilated cardiomyopathy	35/1270	112/7206	0.000389005230198
ko04070	Phosphatidylinositol signaling system	35/1270	112/7206	0.000389005230198
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1270	59/7206	0.000392062395456
ko04371	Apelin signaling pathway	50/1270	177/7206	0.000419783560539
ko05205	Proteoglycans in cancer	27/1270	271/7206	0.000445823457559
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1270	79/7206	0.000478620410908
ko00520	Amino sugar and nucleotide sugar metabolism	1/1270	55/7206	0.000523837543295
ko04964	Proximal tubule bicarbonate reclamation	13/1270	29/7206	0.000614549804845
ko04120	Ubiquitin mediated proteolysis	10/1270	138/7206	0.00063054445046
ko05162	Measles	8/1270	120/7206	0.000649429976793
ko04915	Estrogen signaling pathway	39/1270	131/7206	0.000679402254999
ko04923	Regulation of lipolysis in adipocytes	26/1270	77/7206	0.000720851577268
ko04141	Protein processing in endoplasmic reticulum	16/1270	184/7206	0.000786768846619
ko04750	Inflammatory mediator regulation of TRP channels	36/1270	122/7206	0.00109071316236
ko05161	Hepatitis B	15/1270	173/7206	0.00112938551244
ko04626	Plant-pathogen interaction	9/1270	18/7206	0.00168430045695
ko04710	Circadian rhythm	16/1270	43/7206	0.00199221381229
ko04014	Ras signaling pathway	69/1270	279/7206	0.0022490811869
ko04612	Antigen processing and presentation	4/1270	77/7206	0.00226794842107
ko05321	Inflammatory bowel disease (IBD)	2/1270	56/7206	0.0024623896347
ko05144	Malaria	1/1270	45/7206	0.00273615125494
ko03420	Nucleotide excision repair	1/1270	46/7206	0.00281062329514
ko05166	HTLV-I infection	33/1270	292/7206	0.00284248825693
ko04922	Glucagon signaling pathway	36/1270	128/7206	0.00315152365891
ko05131	Shigellosis	5/1270	82/7206	0.00333187424997
ko00480	Glutathione metabolism	2/1270	55/7206	0.00372345605449
ko03022	Basal transcription factors	1/1270	44/7206	0.00433083436707
ko00590	Arachidonic acid metabolism	2/1270	52/7206	0.00537307293746
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1270	14/7206	0.00563045496999
ko04930	Type II diabetes mellitus	18/1270	54/7206	0.0059916463809
ko04658	Th1 and Th2 cell differentiation	7/1270	96/7206	0.00639600452551
ko04622	RIG-I-like receptor signaling pathway	3/1270	62/7206	0.00639919564212
ko04657	IL-17 signaling pathway	6/1270	87/7206	0.00653960094399
ko05133	Pertussis	6/1270	87/7206	0.00653960094399
ko00240	Pyrimidine metabolism	9/1270	110/7206	0.00757047217073
ko03018	RNA degradation	6/1270	84/7206	0.00891460720125
ko00630	Glyoxylate and dicarboxylate metabolism	1/1270	38/7206	0.00940740821188
ko04146	Peroxisome	7/1270	89/7206	0.0115331003491
ko04217	Necroptosis	19/1270	178/7206	0.0124756798934
ko04115	p53 signaling pathway	5/1270	74/7206	0.0130113210694
ko05145	Toxoplasmosis	12/1270	126/7206	0.0131392833573
ko04630	Jak-STAT signaling pathway	13/1270	132/7206	0.0153177483749
ko04918	Thyroid hormone synthesis	24/1270	86/7206	0.0153730323958
ko04912	GnRH signaling pathway	32/1270	122/7206	0.0160575969858
ko00562	Inositol phosphate metabolism	25/1270	89/7206	0.0162455522285
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1270	100/7206	0.0170805623381
ko04330	Notch signaling pathway	4/1270	62/7206	0.0180365902989
ko04510	Focal adhesion	29/1270	240/7206	0.0199866242103
ko05132	Salmonella infection	9/1270	98/7206	0.0233912386044
ko04620	Toll-like receptor signaling pathway	9/1270	100/7206	0.0236609665032
ko04270	Vascular smooth muscle contraction	38/1270	154/7206	0.0244842729493
ko00310	Lysine degradation	6/1270	73/7206	0.030643892541
ko04213	Longevity regulating pathway - multiple species	23/1270	86/7206	0.0320210580129
ko05215	Prostate cancer	11/1270	111/7206	0.0321243290939
ko04916	Melanogenesis	35/1270	142/7206	0.0338365697009
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1270	40/7206	0.0355130952302
ko05219	Bladder cancer	3/1270	48/7206	0.0358535826901
ko04210	Apoptosis	21/1270	180/7206	0.0368676238414
ko04214	Apoptosis - fly	6/1270	72/7206	0.0417375841666
ko00010	Glycolysis / Gluconeogenesis	20/1270	74/7206	0.0445092507127
ko04640	Hematopoietic cell lineage	5/1270	64/7206	0.045902838812
ko05320	Autoimmune thyroid disease	1/1270	29/7206	0.0478980543615
ko00280	Valine, leucine and isoleucine degradation	4/1270	54/7206	0.0481208371411