ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 82/793 152/7206 8.28578963496e-40 ko05033 Nicotine addiction 45/793 56/7206 1.08632832434e-33 ko04080 Neuroactive ligand-receptor interaction 134/793 423/7206 6.73429805069e-33 ko04727 GABAergic synapse 62/793 110/7206 1.04549746973e-31 ko05032 Morphine addiction 62/793 110/7206 1.04549746973e-31 ko04713 Circadian entrainment 63/793 136/7206 7.57167394545e-26 ko04728 Dopaminergic synapse 73/793 185/7206 1.74480789201e-24 ko04723 Retrograde endocannabinoid signaling 70/793 175/7206 6.35468630905e-24 ko04911 Insulin secretion 50/793 117/7206 7.72639120905e-19 ko04024 cAMP signaling pathway 81/793 279/7206 2.48297258759e-17 ko04725 Cholinergic synapse 56/793 160/7206 3.29953439183e-16 ko05031 Amphetamine addiction 39/793 91/7206 5.25652022385e-15 ko04726 Serotonergic synapse 49/793 137/7206 9.46592746006e-15 ko04020 Calcium signaling pathway 73/793 265/7206 2.21112595612e-14 ko04744 Phototransduction 23/793 36/7206 3.83468535815e-14 ko04721 Synaptic vesicle cycle 35/793 80/7206 6.33915266559e-14 ko05030 Cocaine addiction 33/793 73/7206 1.05826347865e-13 ko04720 Long-term potentiation 39/793 99/7206 1.47589504064e-13 ko04261 Adrenergic signaling in cardiomyocytes 60/793 205/7206 2.92881494348e-13 ko04921 Oxytocin signaling pathway 60/793 209/7206 7.44891290158e-13 ko04970 Salivary secretion 35/793 95/7206 2.5790120116e-11 ko04742 Taste transduction 27/793 61/7206 3.50957148594e-11 ko04925 Aldosterone synthesis and secretion 35/793 105/7206 6.32931060442e-10 ko04010 MAPK signaling pathway 73/793 321/7206 6.96839524981e-10 ko04972 Pancreatic secretion 34/793 111/7206 1.3151238308e-08 ko04971 Gastric acid secretion 31/793 98/7206 2.49486043839e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 24/793 74/7206 5.69145567173e-07 ko04022 cGMP-PKG signaling pathway 48/793 216/7206 1.31144003801e-06 ko03040 Spliceosome 1/793 145/7206 1.31151490892e-06 ko05203 Viral carcinogenesis 9/793 277/7206 2.98610584474e-06 ko04915 Estrogen signaling pathway 33/793 131/7206 3.40026144421e-06 ko04730 Long-term depression 23/793 78/7206 6.13666256454e-06 ko05168 Herpes simplex infection 4/793 182/7206 1.10130766376e-05 ko05414 Dilated cardiomyopathy 28/793 112/7206 2.25149064245e-05 ko04072 Phospholipase D signaling pathway 42/793 197/7206 2.28021565419e-05 ko04260 Cardiac muscle contraction 25/793 98/7206 4.93975615869e-05 ko04062 Chemokine signaling pathway 41/793 201/7206 7.94395718135e-05 ko04740 Olfactory transduction 21/793 80/7206 0.00010345889401 ko04540 Gap junction 29/793 128/7206 0.000145289525103 ko04918 Thyroid hormone synthesis 22/793 86/7206 0.000149663903766 ko04514 Cell adhesion molecules (CAMs) 29/793 130/7206 0.0001723520664 ko05322 Systemic lupus erythematosus 4/793 151/7206 0.000198457856332 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/793 79/7206 0.000350702479861 ko04110 Cell cycle 4/793 145/7206 0.000403613401983 ko04371 Apelin signaling pathway 35/793 177/7206 0.000552224527388 ko04070 Phosphatidylinositol signaling system 25/793 112/7206 0.000605398384459 ko04976 Bile secretion 19/793 80/7206 0.000937928881332 ko05164 Influenza A 6/793 167/7206 0.000973990123393 ko05034 Alcoholism 43/793 238/7206 0.000982969700406 ko04750 Inflammatory mediator regulation of TRP channels 26/793 122/7206 0.0010608520861 ko04630 Jak-STAT signaling pathway 4/793 132/7206 0.00113856943744 ko04924 Renin secretion 20/793 86/7206 0.00132694319475 ko04961 Endocrine and other factor-regulated calcium reabsorption 15/793 59/7206 0.00140628476433 ko04923 Regulation of lipolysis in adipocytes 18/793 77/7206 0.00152738252072 ko04141 Protein processing in endoplasmic reticulum 8/793 184/7206 0.00178387236185 ko04621 NOD-like receptor signaling pathway 6/793 157/7206 0.00178990386983 ko04745 Phototransduction - fly 11/793 38/7206 0.00196289225771 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/793 14/7206 0.00240200797683 ko03013 RNA transport 7/793 166/7206 0.0024569913922 ko05169 Epstein-Barr virus infection 10/793 206/7206 0.00303816449739 ko04120 Ubiquitin mediated proteolysis 5/793 138/7206 0.00345152344396 ko04146 Peroxisome 2/793 89/7206 0.0034651519657 ko04014 Ras signaling pathway 46/793 279/7206 0.00448270340367 ko05162 Measles 4/793 120/7206 0.00456203711891 ko00513 Various types of N-glycan biosynthesis 11/793 42/7206 0.00463725780527 ko04912 GnRH signaling pathway 24/793 122/7206 0.00488100034871 ko04015 Rap1 signaling pathway 45/793 278/7206 0.00795961550546 ko00240 Pyrimidine metabolism 4/793 110/7206 0.00853469831116 ko05410 Hypertrophic cardiomyopathy (HCM) 20/793 100/7206 0.00882944363744 ko05202 Transcriptional misregulation in cancer 10/793 188/7206 0.00901145241673 ko03008 Ribosome biogenesis in eukaryotes 2/793 79/7206 0.0103603804354 ko00512 Mucin type O-glycan biosynthesis 8/793 29/7206 0.0108430845148 ko04964 Proximal tubule bicarbonate reclamation 8/793 29/7206 0.0108430845148 ko04930 Type II diabetes mellitus 12/793 54/7206 0.0145129701808 ko00515 Mannose type O-glycan biosynthesis 7/793 25/7206 0.0154831666133 ko05231 Choline metabolism in cancer 24/793 134/7206 0.0166913394466 ko04550 Signaling pathways regulating pluripotency of stem cells 9/793 165/7206 0.0167517300029 ko05205 Proteoglycans in cancer 18/793 271/7206 0.0172909464924 ko05321 Inflammatory bowel disease (IBD) 1/793 56/7206 0.0179921635804 ko04360 Axon guidance 37/793 233/7206 0.0190965942443 ko04973 Carbohydrate digestion and absorption 10/793 42/7206 0.021053624438 ko04214 Apoptosis - fly 2/793 72/7206 0.0213107521628 ko00310 Lysine degradation 2/793 73/7206 0.0217696310445 ko05110 Vibrio cholerae infection 13/793 63/7206 0.0234486777075 ko04270 Vascular smooth muscle contraction 26/793 154/7206 0.0258671927485 ko00480 Glutathione metabolism 1/793 55/7206 0.0272577256562 ko04916 Melanogenesis 24/793 142/7206 0.0295546075776 ko04071 Sphingolipid signaling pathway 27/793 162/7206 0.0296384949359 ko04932 Non-alcoholic fatty liver disease (NAFLD) 11/793 182/7206 0.030046915355 ko04064 NF-kappa B signaling pathway 4/793 96/7206 0.0310668899837 ko04962 Vasopressin-regulated water reabsorption 12/793 58/7206 0.0312615069232 ko05016 Huntington's disease 14/793 215/7206 0.0346859132662 ko04213 Longevity regulating pathway - multiple species 16/793 86/7206 0.0350903246084 ko00230 Purine metabolism 31/793 194/7206 0.0352196150068 ko04140 Autophagy - animal 10/793 164/7206 0.0427009120886 ko01524 Platinum drug resistance 3/793 76/7206 0.0430357484894 ko05418 Fluid shear stress and atherosclerosis 11/793 173/7206 0.0485964634529