ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	185/1146	423/7206	3.71379666102e-45
ko04724	Glutamatergic synapse	85/1146	152/7206	2.5526986218e-30
ko05033	Nicotine addiction	47/1146	56/7206	2.30472615115e-29
ko05032	Morphine addiction	64/1146	110/7206	2.29718821493e-24
ko04727	GABAergic synapse	63/1146	110/7206	1.7468364193e-23
ko04713	Circadian entrainment	71/1146	136/7206	4.52376568644e-23
ko04728	Dopaminergic synapse	84/1146	185/7206	7.36578732421e-22
ko04725	Cholinergic synapse	71/1146	160/7206	5.94643320119e-18
ko04721	Synaptic vesicle cycle	46/1146	80/7206	1.47693235134e-17
ko04723	Retrograde endocannabinoid signaling	74/1146	175/7206	3.19406944882e-17
ko04024	cAMP signaling pathway	97/1146	279/7206	3.92773842907e-15
ko04744	Phototransduction	27/1146	36/7206	4.62166247386e-15
ko04020	Calcium signaling pathway	92/1146	265/7206	1.55023849096e-14
ko04742	Taste transduction	35/1146	61/7206	1.26724004085e-13
ko04726	Serotonergic synapse	56/1146	137/7206	1.38900069197e-12
ko04911	Insulin secretion	49/1146	117/7206	1.24782844381e-11
ko04921	Oxytocin signaling pathway	72/1146	209/7206	1.93185069695e-11
ko04261	Adrenergic signaling in cardiomyocytes	71/1146	205/7206	2.13131342867e-11
ko05031	Amphetamine addiction	40/1146	91/7206	1.6613007821e-10
ko03040	Spliceosome	1/1146	145/7206	5.17411595903e-10
ko04720	Long-term potentiation	40/1146	99/7206	3.47625295431e-09
ko05203	Viral carcinogenesis	13/1146	277/7206	6.78175649523e-09
ko04970	Salivary secretion	37/1146	95/7206	4.30465347835e-08
ko04060	Cytokine-cytokine receptor interaction	8/1146	191/7206	5.53149476915e-07
ko05030	Cocaine addiction	29/1146	73/7206	7.64495443541e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1146	74/7206	1.06906004302e-06
ko04925	Aldosterone synthesis and secretion	37/1146	105/7206	1.06976590837e-06
ko05322	Systemic lupus erythematosus	5/1146	151/7206	1.36015098695e-06
ko03013	RNA transport	7/1146	166/7206	2.83066848054e-06
ko05164	Influenza A	7/1146	167/7206	2.83276225508e-06
ko04022	cGMP-PKG signaling pathway	61/1146	216/7206	2.84126752822e-06
ko04740	Olfactory transduction	30/1146	80/7206	2.96870541509e-06
ko04971	Gastric acid secretion	34/1146	98/7206	4.21506954577e-06
ko05168	Herpes simplex infection	9/1146	182/7206	7.29695638972e-06
ko04360	Axon guidance	63/1146	233/7206	1.00800376748e-05
ko04621	NOD-like receptor signaling pathway	7/1146	157/7206	1.20305407827e-05
ko04514	Cell adhesion molecules (CAMs)	40/1146	130/7206	1.68641574517e-05
ko04070	Phosphatidylinositol signaling system	36/1146	112/7206	1.91324182381e-05
ko04610	Complement and coagulation cascades	1/1146	79/7206	3.28156642543e-05
ko04010	MAPK signaling pathway	79/1146	321/7206	4.30681352433e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1146	79/7206	6.39853953693e-05
ko05205	Proteoglycans in cancer	21/1146	271/7206	8.61467876054e-05
ko04745	Phototransduction - fly	16/1146	38/7206	0.000102976440455
ko04120	Ubiquitin mediated proteolysis	7/1146	138/7206	0.000136598279256
ko04141	Protein processing in endoplasmic reticulum	12/1146	184/7206	0.00014227460519
ko05161	Hepatitis B	11/1146	173/7206	0.00019916600154
ko04972	Pancreatic secretion	33/1146	111/7206	0.000204036164675
ko03008	Ribosome biogenesis in eukaryotes	2/1146	79/7206	0.000268017576886
ko05169	Epstein-Barr virus infection	15/1146	206/7206	0.000307834218988
ko05140	Leishmaniasis	2/1146	75/7206	0.000388787919354
ko04730	Long-term depression	25/1146	78/7206	0.000440385424082
ko04072	Phospholipase D signaling pathway	50/1146	197/7206	0.000497987996991
ko04110	Cell cycle	9/1146	145/7206	0.000525811541263
ko05414	Dilated cardiomyopathy	32/1146	112/7206	0.000602487783955
ko04064	NF-kappa B signaling pathway	4/1146	96/7206	0.000603626101725
ko04260	Cardiac muscle contraction	29/1146	98/7206	0.0006721617103
ko04966	Collecting duct acid secretion	11/1146	26/7206	0.00119775854234
ko05162	Measles	7/1146	120/7206	0.00143453904934
ko04612	Antigen processing and presentation	3/1146	77/7206	0.00153714460605
ko04924	Renin secretion	25/1146	86/7206	0.0016829860081
ko04976	Bile secretion	24/1146	80/7206	0.00170527225016
ko04640	Hematopoietic cell lineage	2/1146	64/7206	0.00284702587989
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1146	14/7206	0.00309034177884
ko05166	HTLV-I infection	29/1146	292/7206	0.00322589865404
ko04540	Gap junction	33/1146	128/7206	0.00331841260493
ko04964	Proximal tubule bicarbonate reclamation	11/1146	29/7206	0.003392006091
ko00240	Pyrimidine metabolism	7/1146	110/7206	0.00361354520451
ko04750	Inflammatory mediator regulation of TRP channels	32/1146	122/7206	0.00368972368266
ko04626	Plant-pathogen interaction	8/1146	18/7206	0.0039168419107
ko04923	Regulation of lipolysis in adipocytes	22/1146	77/7206	0.00432857942734
ko04014	Ras signaling pathway	62/1146	279/7206	0.00444819325707
ko04146	Peroxisome	5/1146	89/7206	0.00510867141707
ko04510	Focal adhesion	23/1146	240/7206	0.00523709472827
ko04915	Estrogen signaling pathway	33/1146	131/7206	0.00529902620409
ko04710	Circadian rhythm	14/1146	43/7206	0.00568639663207
ko03022	Basal transcription factors	1/1146	44/7206	0.00678461625941
ko05144	Malaria	1/1146	45/7206	0.00679711366281
ko00071	Fatty acid degradation	1/1146	45/7206	0.00679711366281
ko03420	Nucleotide excision repair	1/1146	46/7206	0.0070448556415
ko00562	Inositol phosphate metabolism	24/1146	89/7206	0.00784450659107
ko00480	Glutathione metabolism	2/1146	55/7206	0.00852983624754
ko05321	Inflammatory bowel disease (IBD)	2/1146	56/7206	0.00882191773083
ko05110	Vibrio cholerae infection	18/1146	63/7206	0.00909206657963
ko04115	p53 signaling pathway	4/1146	74/7206	0.00982795849045
ko04711	Circadian rhythm - fly	6/1146	13/7206	0.0100002640691
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1146	59/7206	0.011173500587
ko00330	Arginine and proline metabolism	3/1146	61/7206	0.0133844803853
ko04622	RIG-I-like receptor signaling pathway	3/1146	62/7206	0.0134855234836
ko00290	Valine, leucine and isoleucine biosynthesis	3/1146	4/7206	0.0141430708399
ko04630	Jak-STAT signaling pathway	11/1146	132/7206	0.0156326724069
ko04658	Th1 and Th2 cell differentiation	7/1146	96/7206	0.0166149505248
ko04657	IL-17 signaling pathway	6/1146	87/7206	0.0177129953543
ko05133	Pertussis	6/1146	87/7206	0.0177129953543
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1146	100/7206	0.0182827646177
ko04350	TGF-beta signaling pathway	8/1146	103/7206	0.0205322911951
ko00630	Glyoxylate and dicarboxylate metabolism	1/1146	38/7206	0.0232114346488
ko03410	Base excision repair	1/1146	38/7206	0.0232114346488
ko04930	Type II diabetes mellitus	15/1146	54/7206	0.0237063775083
ko03018	RNA degradation	6/1146	84/7206	0.0239590443849
ko05215	Prostate cancer	9/1146	111/7206	0.0251111181335
ko05145	Toxoplasmosis	11/1146	126/7206	0.0262324546213
ko05219	Bladder cancer	2/1146	48/7206	0.0267368557666
ko04922	Glucagon signaling pathway	30/1146	128/7206	0.0271600798485
ko04620	Toll-like receptor signaling pathway	8/1146	100/7206	0.027170962937
ko04722	Neurotrophin signaling pathway	36/1146	160/7206	0.0280565919188
ko04371	Apelin signaling pathway	39/1146	177/7206	0.0285534718344
ko04210	Apoptosis	18/1146	180/7206	0.0295941099594
ko04140	Autophagy - animal	16/1146	164/7206	0.0301656940953
ko05131	Shigellosis	6/1146	82/7206	0.032416968899
ko00860	Porphyrin and chlorophyll metabolism	1/1146	34/7206	0.0335162185973
ko04214	Apoptosis - fly	5/1146	72/7206	0.034671626158
ko00310	Lysine degradation	5/1146	73/7206	0.0350030425149
ko04330	Notch signaling pathway	4/1146	62/7206	0.0366761386153
ko04217	Necroptosis	18/1146	178/7206	0.0371451544246
ko00512	Mucin type O-glycan biosynthesis	9/1146	29/7206	0.0378056324653
ko00280	Valine, leucine and isoleucine degradation	3/1146	54/7206	0.0380408407573
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1146	182/7206	0.0400192049429
ko04668	TNF signaling pathway	11/1146	120/7206	0.0433303169506