ko pathway ratio_in_study ratio_in_pop p_value ko05340 Primary immunodeficiency 15/426 30/7206 2.02272626317e-11 ko04060 Cytokine-cytokine receptor interaction 36/426 191/7206 3.08562213048e-10 ko05145 Toxoplasmosis 25/426 126/7206 6.08158415266e-08 ko04621 NOD-like receptor signaling pathway 28/426 157/7206 1.07612520466e-07 ko05164 Influenza A 28/426 167/7206 4.10272879139e-07 ko04064 NF-kappa B signaling pathway 20/426 96/7206 5.7463180707e-07 ko00120 Primary bile acid biosynthesis 9/426 20/7206 7.59633281082e-07 ko04380 Osteoclast differentiation 24/426 134/7206 8.21728822171e-07 ko04659 Th17 cell differentiation 20/426 106/7206 2.97721853061e-06 ko05150 Staphylococcus aureus infection 11/426 36/7206 4.23335934711e-06 ko05140 Leishmaniasis 16/426 75/7206 5.66515497832e-06 ko04612 Antigen processing and presentation 16/426 77/7206 8.11777024529e-06 ko04658 Th1 and Th2 cell differentiation 18/426 96/7206 1.02200055129e-05 ko05321 Inflammatory bowel disease (IBD) 13/426 56/7206 1.63742486437e-05 ko00140 Steroid hormone biosynthesis 11/426 41/7206 1.70062499125e-05 ko04660 T cell receptor signaling pathway 20/426 124/7206 3.41242029398e-05 ko05168 Herpes simplex infection 26/426 182/7206 3.51462576232e-05 ko04672 Intestinal immune network for IgA production 10/426 37/7206 3.85234142636e-05 ko04650 Natural killer cell mediated cytotoxicity 17/426 97/7206 4.48026586908e-05 ko04662 B cell receptor signaling pathway 16/426 88/7206 4.70797145381e-05 ko04146 Peroxisome 16/426 89/7206 5.43443272298e-05 ko04217 Necroptosis 25/426 178/7206 5.92157412354e-05 ko00592 alpha-Linolenic acid metabolism 7/426 19/7206 6.49891953381e-05 ko05162 Measles 19/426 120/7206 6.94170858794e-05 ko01212 Fatty acid metabolism 12/426 60/7206 0.000162756383405 ko00590 Arachidonic acid metabolism 11/426 52/7206 0.000180115399288 ko05320 Autoimmune thyroid disease 8/426 29/7206 0.000199055937256 ko04390 Hippo signaling pathway 1/426 188/7206 0.000224346513998 ko04630 Jak-STAT signaling pathway 19/426 132/7206 0.000253648327998 ko04310 Wnt signaling pathway 1/426 181/7206 0.000329085229336 ko05330 Allograft rejection 7/426 24/7206 0.000344746823408 ko04062 Chemokine signaling pathway 25/426 201/7206 0.000362035663465 ko05152 Tuberculosis 24/426 187/7206 0.000376505970761 ko05204 Chemical carcinogenesis 10/426 48/7206 0.000402589497137 ko00980 Metabolism of xenobiotics by cytochrome P450 9/426 40/7206 0.000428384432927 ko00350 Tyrosine metabolism 8/426 33/7206 0.000522502451257 ko03320 PPAR signaling pathway 12/426 69/7206 0.000631942918393 ko04620 Toll-like receptor signaling pathway 15/426 100/7206 0.000718993259854 ko04622 RIG-I-like receptor signaling pathway 11/426 62/7206 0.000888045809499 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/426 191/7206 0.000935207089933 ko00071 Fatty acid degradation 9/426 45/7206 0.00106715738423 ko00982 Drug metabolism - cytochrome P450 8/426 37/7206 0.00117974644177 ko05133 Pertussis 13/426 87/7206 0.00166050983045 ko00950 Isoquinoline alkaloid biosynthesis 4/426 10/7206 0.00190035574683 ko05034 Alcoholism 4/426 238/7206 0.00197109577111 ko03040 Spliceosome 1/426 145/7206 0.00220896377833 ko04110 Cell cycle 1/426 145/7206 0.00220896377833 ko00380 Tryptophan metabolism 9/426 50/7206 0.00232121899996 ko04623 Cytosolic DNA-sensing pathway 8/426 41/7206 0.00237226104394 ko00360 Phenylalanine metabolism 5/426 17/7206 0.00241130295841 ko05310 Asthma 5/426 17/7206 0.00241130295841 ko01040 Biosynthesis of unsaturated fatty acids 6/426 25/7206 0.00278533742895 ko05224 Breast cancer 2/426 174/7206 0.00297226839796 ko05332 Graft-versus-host disease 5/426 18/7206 0.00317886361711 ko04640 Hematopoietic cell lineage 10/426 64/7206 0.00400010237335 ko05144 Malaria 8/426 45/7206 0.00435132696698 ko05160 Hepatitis C 18/426 153/7206 0.00471851456864 ko04666 Fc gamma R-mediated phagocytosis 15/426 122/7206 0.00586952444707 ko00100 Steroid biosynthesis 5/426 21/7206 0.00651951970676 ko03010 Ribosome 1/426 129/7206 0.00703897581566 ko04360 Axon guidance 5/426 233/7206 0.0101923668045 ko04611 Platelet activation 18/426 163/7206 0.0103126442967 ko03050 Proteasome 8/426 54/7206 0.0132203446069 ko04723 Retrograde endocannabinoid signaling 3/426 175/7206 0.0135771870319 ko04530 Tight junction 5/426 228/7206 0.0140890136152 ko04911 Insulin secretion 1/426 117/7206 0.0152164333579 ko00500 Starch and sucrose metabolism 6/426 35/7206 0.01549660583 ko04916 Melanogenesis 2/426 142/7206 0.0175763799008 ko00920 Sulfur metabolism 3/426 10/7206 0.0180208589441 ko04550 Signaling pathways regulating pluripotency of stem cells 3/426 165/7206 0.0184415104517 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/426 4/7206 0.0193171203707 ko00643 Styrene degradation 2/426 4/7206 0.0193171203707 ko05323 Rheumatoid arthritis 11/426 89/7206 0.0195368933552 ko05161 Hepatitis B 18/426 173/7206 0.0203571005469 ko04727 GABAergic synapse 1/426 110/7206 0.0219148053665 ko04664 Fc epsilon RI signaling pathway 10/426 77/7206 0.0235909549391 ko04514 Cell adhesion molecules (CAMs) 14/426 130/7206 0.0240812388361 ko04713 Circadian entrainment 2/426 136/7206 0.0250516076472 ko04610 Complement and coagulation cascades 10/426 79/7206 0.0252408427045 ko05200 Pathways in cancer 18/426 492/7206 0.0287380855881 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/426 5/7206 0.0309446360512 ko00281 Geraniol degradation 2/426 5/7206 0.0309446360512 ko05206 MicroRNAs in cancer 4/426 177/7206 0.0345770864578 ko00983 Drug metabolism - other enzymes 6/426 42/7206 0.035459163605 ko00830 Retinol metabolism 6/426 42/7206 0.035459163605 ko04940 Type I diabetes mellitus 5/426 32/7206 0.037918384996 ko04145 Phagosome 16/426 162/7206 0.0410010289499 ko00480 Glutathione metabolism 7/426 55/7206 0.0419150092779 ko05416 Viral myocarditis 7/426 55/7206 0.0419150092779 ko00362 Benzoate degradation 2/426 6/7206 0.0446232351642 ko04020 Calcium signaling pathway 8/426 265/7206 0.0450760000708 ko05211 Renal cell carcinoma 1/426 96/7206 0.0452487988478 ko00220 Arginine biosynthesis 4/426 24/7206 0.0499866961578