ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 42/443 191/7206 1.50773058443e-13 ko05340 Primary immunodeficiency 15/443 30/7206 3.54663214446e-11 ko04380 Osteoclast differentiation 27/443 134/7206 2.886651848e-08 ko05145 Toxoplasmosis 26/443 126/7206 3.1350389059e-08 ko04621 NOD-like receptor signaling pathway 28/443 157/7206 2.44382151415e-07 ko05150 Staphylococcus aureus infection 12/443 36/7206 8.11768269406e-07 ko05321 Inflammatory bowel disease (IBD) 15/443 56/7206 8.3960925921e-07 ko00120 Primary bile acid biosynthesis 9/443 20/7206 1.05757545273e-06 ko04658 Th1 and Th2 cell differentiation 20/443 96/7206 1.06868957791e-06 ko04064 NF-kappa B signaling pathway 20/443 96/7206 1.06868957791e-06 ko04659 Th17 cell differentiation 21/443 106/7206 1.37632045144e-06 ko05140 Leishmaniasis 17/443 75/7206 2.02374156436e-06 ko05164 Influenza A 27/443 167/7206 2.95174900842e-06 ko04612 Antigen processing and presentation 17/443 77/7206 2.98334889603e-06 ko04672 Intestinal immune network for IgA production 11/443 37/7206 8.31827505832e-06 ko04650 Natural killer cell mediated cytotoxicity 18/443 97/7206 2.02470252461e-05 ko05162 Measles 20/443 120/7206 3.66653381993e-05 ko05168 Herpes simplex infection 26/443 182/7206 5.14176393734e-05 ko00590 Arachidonic acid metabolism 12/443 52/7206 5.42882056306e-05 ko04660 T cell receptor signaling pathway 20/443 124/7206 5.94621125926e-05 ko04217 Necroptosis 25/443 178/7206 9.10709950252e-05 ko00350 Tyrosine metabolism 9/443 33/7206 0.000118314932742 ko04062 Chemokine signaling pathway 27/443 201/7206 0.000126615794924 ko00140 Steroid hormone biosynthesis 10/443 41/7206 0.000138773150618 ko05320 Autoimmune thyroid disease 8/443 29/7206 0.000260689205784 ko05152 Tuberculosis 25/443 187/7206 0.000260837931816 ko04662 B cell receptor signaling pathway 15/443 88/7206 0.00026536196535 ko04610 Complement and coagulation cascades 14/443 79/7206 0.000278381454278 ko04620 Toll-like receptor signaling pathway 16/443 100/7206 0.000353862108397 ko00360 Phenylalanine metabolism 6/443 17/7206 0.000360691717646 ko05330 Allograft rejection 7/443 24/7206 0.000437960953127 ko03013 RNA transport 1/443 166/7206 0.000475021334111 ko05204 Chemical carcinogenesis 10/443 48/7206 0.000549354469762 ko00980 Metabolism of xenobiotics by cytochrome P450 9/443 40/7206 0.000570870223309 ko00592 alpha-Linolenic acid metabolism 6/443 19/7206 0.000711589279076 ko03320 PPAR signaling pathway 12/443 69/7206 0.000894044593113 ko04146 Peroxisome 14/443 89/7206 0.000971425245703 ko04622 RIG-I-like receptor signaling pathway 11/443 62/7206 0.00122458101754 ko04630 Jak-STAT signaling pathway 18/443 132/7206 0.00133469830352 ko05144 Malaria 9/443 45/7206 0.00140693619126 ko00071 Fatty acid degradation 9/443 45/7206 0.00140693619126 ko04310 Wnt signaling pathway 2/443 181/7206 0.00144124979327 ko00982 Drug metabolism - cytochrome P450 8/443 37/7206 0.00151893556357 ko04640 Hematopoietic cell lineage 11/443 64/7206 0.00160340857157 ko05167 Kaposi's sarcoma-associated herpesvirus infection 23/443 191/7206 0.00185795013279 ko04360 Axon guidance 4/443 233/7206 0.00198614246058 ko05224 Breast cancer 2/443 174/7206 0.0020618554084 ko00950 Isoquinoline alkaloid biosynthesis 4/443 10/7206 0.00219753668711 ko03040 Spliceosome 1/443 145/7206 0.00232386398353 ko05133 Pertussis 13/443 87/7206 0.00235263997366 ko04611 Platelet activation 20/443 163/7206 0.00261142897947 ko05310 Asthma 5/443 17/7206 0.00286428887529 ko05323 Rheumatoid arthritis 13/443 89/7206 0.00289065124906 ko00380 Tryptophan metabolism 9/443 50/7206 0.003027937735 ko04623 Cytosolic DNA-sensing pathway 8/443 41/7206 0.00302872709491 ko05332 Graft-versus-host disease 5/443 18/7206 0.00376854347431 ko00362 Benzoate degradation 3/443 6/7206 0.00401315124636 ko03010 Ribosome 1/443 129/7206 0.00470751127768 ko04390 Hippo signaling pathway 3/443 188/7206 0.00494810954813 ko05034 Alcoholism 5/443 238/7206 0.00548744378025 ko05161 Hepatitis B 20/443 173/7206 0.00573368767244 ko05142 Chagas disease (American trypanosomiasis) 16/443 130/7206 0.00819870881575 ko05160 Hepatitis C 18/443 153/7206 0.00923682970553 ko04910 Insulin signaling pathway 3/443 172/7206 0.00950333030814 ko04666 Fc gamma R-mediated phagocytosis 15/443 122/7206 0.0112807373882 ko04110 Cell cycle 2/443 145/7206 0.0127147982564 ko04550 Signaling pathways regulating pluripotency of stem cells 3/443 165/7206 0.0132151421084 ko04727 GABAergic synapse 1/443 110/7206 0.0145319452901 ko00480 Glutathione metabolism 8/443 55/7206 0.0182328781145 ko05132 Salmonella infection 12/443 98/7206 0.0183985564353 ko00920 Sulfur metabolism 3/443 10/7206 0.0200148929866 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/443 4/7206 0.0208235163593 ko00643 Styrene degradation 2/443 4/7206 0.0208235163593 ko04530 Tight junction 6/443 228/7206 0.02368933737 ko01212 Fatty acid metabolism 8/443 60/7206 0.0293877602148 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/443 5/7206 0.0333043328539 ko00281 Geraniol degradation 2/443 5/7206 0.0333043328539 ko05131 Shigellosis 10/443 82/7206 0.0333175861728 ko04137 Mitophagy - animal 10/443 82/7206 0.0333175861728 ko00100 Steroid biosynthesis 4/443 21/7206 0.0366233476685 ko04514 Cell adhesion molecules (CAMs) 14/443 130/7206 0.0395495486636 ko00051 Fructose and mannose metabolism 6/443 42/7206 0.0417358656509 ko00830 Retinol metabolism 6/443 42/7206 0.0417358656509 ko00565 Ether lipid metabolism 6/443 42/7206 0.0417358656509 ko04940 Type I diabetes mellitus 5/443 32/7206 0.0437555021079 ko05134 Legionellosis 9/443 74/7206 0.0455229090476 ko03050 Proteasome 7/443 54/7206 0.0459649753275 ko04911 Insulin secretion 2/443 117/7206 0.0487050836082 ko04916 Melanogenesis 3/443 142/7206 0.0491672438834