ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 146/755 423/7206 1.18873379902e-43 ko05033 Nicotine addiction 43/755 56/7206 1.24494660786e-31 ko04724 Glutamatergic synapse 72/755 152/7206 1.27871060984e-31 ko04727 GABAergic synapse 51/755 110/7206 4.169611554e-22 ko05032 Morphine addiction 51/755 110/7206 4.169611554e-22 ko04723 Retrograde endocannabinoid signaling 62/755 175/7206 3.16766414492e-19 ko04728 Dopaminergic synapse 64/755 185/7206 3.39439267077e-19 ko04721 Synaptic vesicle cycle 39/755 80/7206 3.93019920697e-18 ko04713 Circadian entrainment 51/755 136/7206 3.31932362943e-17 ko04024 cAMP signaling pathway 77/755 279/7206 2.21695933727e-16 ko04725 Cholinergic synapse 53/755 160/7206 3.69239150806e-15 ko04911 Insulin secretion 42/755 117/7206 1.30142548612e-13 ko04020 Calcium signaling pathway 67/755 265/7206 2.22221418651e-12 ko04720 Long-term potentiation 35/755 99/7206 2.45926544181e-11 ko05031 Amphetamine addiction 33/755 91/7206 4.18238890418e-11 ko04726 Serotonergic synapse 42/755 137/7206 5.04676004364e-11 ko04921 Oxytocin signaling pathway 54/755 209/7206 1.98499027122e-10 ko04261 Adrenergic signaling in cardiomyocytes 51/755 205/7206 1.99869328514e-09 ko04742 Taste transduction 24/755 61/7206 2.92397992084e-09 ko05030 Cocaine addiction 26/755 73/7206 7.77611879576e-09 ko04970 Salivary secretion 28/755 95/7206 2.21511551471e-07 ko05014 Amyotrophic lateral sclerosis (ALS) 24/755 74/7206 2.27602276381e-07 ko04744 Phototransduction 15/755 36/7206 1.18278563724e-06 ko04010 MAPK signaling pathway 62/755 321/7206 1.38905037746e-06 ko04925 Aldosterone synthesis and secretion 28/755 105/7206 2.08770210527e-06 ko05164 Influenza A 2/755 167/7206 2.57650827476e-06 ko05203 Viral carcinogenesis 8/755 277/7206 2.88702095308e-06 ko03040 Spliceosome 1/755 145/7206 3.1456947069e-06 ko04971 Gastric acid secretion 26/755 98/7206 5.33829273914e-06 ko04072 Phospholipase D signaling pathway 41/755 197/7206 1.47091151135e-05 ko04972 Pancreatic secretion 27/755 111/7206 2.43718722365e-05 ko05168 Herpes simplex infection 4/755 182/7206 3.64500570543e-05 ko04060 Cytokine-cytokine receptor interaction 5/755 191/7206 5.96148456543e-05 ko04514 Cell adhesion molecules (CAMs) 29/755 130/7206 6.52599634344e-05 ko04730 Long-term depression 20/755 78/7206 0.000108199162983 ko04022 cGMP-PKG signaling pathway 41/755 216/7206 0.000158803120236 ko04260 Cardiac muscle contraction 23/755 98/7206 0.000165134922337 ko05169 Epstein-Barr virus infection 7/755 206/7206 0.00028589344466 ko04120 Ubiquitin mediated proteolysis 3/755 138/7206 0.000351613327229 ko05162 Measles 2/755 120/7206 0.000402347820521 ko05322 Systemic lupus erythematosus 4/755 151/7206 0.000413992408328 ko04070 Phosphatidylinositol signaling system 24/755 112/7206 0.000514914616846 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 19/755 79/7206 0.000542452948294 ko05110 Vibrio cholerae infection 16/755 63/7206 0.000581914650814 ko04110 Cell cycle 4/755 145/7206 0.000842524155427 ko04966 Collecting duct acid secretion 9/755 26/7206 0.000873976939827 ko05205 Proteoglycans in cancer 13/755 271/7206 0.00110654823169 ko04745 Phototransduction - fly 11/755 38/7206 0.00131260000635 ko04621 NOD-like receptor signaling pathway 5/755 157/7206 0.00132940348845 ko04140 Autophagy - animal 6/755 164/7206 0.001832506495 ko03013 RNA transport 6/755 166/7206 0.00185432071353 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/755 14/7206 0.00185871710387 ko04540 Gap junction 25/755 128/7206 0.00191553050461 ko03008 Ribosome biogenesis in eukaryotes 1/755 79/7206 0.00266354930539 ko04915 Estrogen signaling pathway 25/755 131/7206 0.00344017696989 ko05161 Hepatitis B 7/755 173/7206 0.00348432244974 ko04612 Antigen processing and presentation 1/755 77/7206 0.00406043208339 ko00240 Pyrimidine metabolism 3/755 110/7206 0.00418916738687 ko05215 Prostate cancer 3/755 111/7206 0.00426852753012 ko04750 Inflammatory mediator regulation of TRP channels 23/755 122/7206 0.00435168109411 ko04141 Protein processing in endoplasmic reticulum 8/755 184/7206 0.00460561073149 ko04740 Olfactory transduction 17/755 80/7206 0.00470487333961 ko04550 Signaling pathways regulating pluripotency of stem cells 7/755 165/7206 0.00636409023621 ko05414 Dilated cardiomyopathy 21/755 112/7206 0.00744490452007 ko04350 TGF-beta signaling pathway 3/755 103/7206 0.00847654876451 ko04630 Jak-STAT signaling pathway 5/755 132/7206 0.00899352386912 ko04932 Non-alcoholic fatty liver disease (NAFLD) 9/755 182/7206 0.00986775693733 ko05166 HTLV-I infection 18/755 292/7206 0.0111413058896 ko04064 NF-kappa B signaling pathway 3/755 96/7206 0.0116064612037 ko04640 Hematopoietic cell lineage 1/755 64/7206 0.0125325934452 ko04510 Focal adhesion 14/755 240/7206 0.0135754488262 ko04014 Ras signaling pathway 42/755 279/7206 0.0161748366394 ko04218 Cellular senescence 9/755 177/7206 0.0173344714686 ko04330 Notch signaling pathway 1/755 62/7206 0.0191445043965 ko04924 Renin secretion 16/755 86/7206 0.0199931742698 ko05140 Leishmaniasis 2/755 75/7206 0.0214931482042 ko01524 Platinum drug resistance 2/755 76/7206 0.021803487478 ko04146 Peroxisome 3/755 89/7206 0.0226631424194 ko05222 Small cell lung cancer 3/755 89/7206 0.0226631424194 ko05034 Alcoholism 36/755 238/7206 0.0231621471121 ko04976 Bile secretion 15/755 80/7206 0.0251215938941 ko04210 Apoptosis 10/755 180/7206 0.0261449875539 ko05010 Alzheimer's disease 31/755 202/7206 0.0265408872756 ko00480 Glutathione metabolism 1/755 55/7206 0.0267539875655 ko04964 Proximal tubule bicarbonate reclamation 7/755 29/7206 0.0269315404585 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/755 59/7206 0.0288836316895 ko04214 Apoptosis - fly 2/755 72/7206 0.0309352626671 ko00310 Lysine degradation 2/755 73/7206 0.0316284659603 ko04626 Plant-pathogen interaction 5/755 18/7206 0.0335251818991 ko05120 Epithelial cell signaling in Helicobacter pylori infection 16/755 92/7206 0.0382344894959 ko05200 Pathways in cancer 38/755 492/7206 0.0392823674026 ko05217 Basal cell carcinoma 2/755 68/7206 0.0437495996344 ko04137 Mitophagy - animal 3/755 82/7206 0.0439705628519 ko05410 Hypertrophic cardiomyopathy (HCM) 17/755 100/7206 0.0459668603477 ko04360 Axon guidance 34/755 233/7206 0.0492385562187 ko04668 TNF signaling pathway 6/755 120/7206 0.0495865520052